C1QTNF9 Protein (AA 20-333) (His tag)

Catalog No. ABIN7505063

Product Details

Target: C1QTNF9 (C1q and Tumor Necrosis Factor Related Protein 9 (C1QTNF9))

Protein Type: Recombinant

Protein Characteristics: AA 20-333

Origin: Human

Source: Escherichia coli (E. coli)

Purification tag / Conjugate: This C1QTNF9 protein is labelled with His tag.

Sequence: Gln 0-Pro 333

Characteristics: A DNA sequence encoding the Human C1QTNF9 protein (P0C862) (Gln 20-Pro 333) was expressed with a N-His tag.

Purity: > 95 % as determined by reducing SDS-PAGE.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization.

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Expiry Date: 12 months

Target Details

Target: C1QTNF9 (C1q and Tumor Necrosis Factor Related Protein 9 (C1QTNF9))

Alternative Name: C1QTNF9 (C1QTNF9 Products)

Background:

Abbreviation: C1QTNF9

Target Synonym: AQL1,C1q and tumor necrosis factor related protein 9,C1qTNF9,CTRP9,MGC48915,C1QTNF9A

Background: C1qTNF9, also known as CTRP9, is an approximately 40 kDa member of the C1q and TNF-related protein family. Like all members of this protein family, C1qTNF9 consists of a short variable region, a collagenous domain that can be hydroxylated, and a C1q-like globular domain. Human C1qTNF9 shares 85 % amino acid sequence identity with the mouse and rat orthologs. Both the mouse and human C1qTNF9 proteins are expressed in adipose tissue, but the mouse protein has also been detected in the heart, lung, muscle, kidney, testis, lymph node, smooth muscle, prostate, thymus, and uterus. They have both also been shown to be secreted as trimers and higher order multimers and also to form hetero-oligomers with Adiponectin. Mouse C1qTNF9 can stimulate the phosphorylation of AMPK, Akt, and eNOS. Also in mice, C1qTNF9 may have an important role in cardiac and metabolic health. Its expression has a cardioprotective effect following acute myocardial infarction that may be dependent on AMPK activation. Additionally, transgenic mice overexpressing C1qTNF9 are resistant to high fat diet?induced obesity. This metabolic role may be conserved, since C1qTNF9 serum levels have been shown to inversely correlate with metabolic syndrome in humans.

Molecular Weight:

Calculated MW: 34.43 kDa

Observed MW: 35 kDa

UniProt: P0C862