COPRS Protein (AA 1-184) (His tag)
custom-made
COPRS
Origin: Human
Host: HEK-293 Cells
Recombinant
> 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
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- Target See all COPRS Proteins
- COPRS (Coordinator of PRMT5, Differentiation Stimulator (COPRS))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 1-184
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Origin
- Human
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This COPRS protein is labelled with His tag.
- Purpose
- Custom-made recombinant COPRS Protein expressed in mammalian cells.
- Sequence
- MDLQAAGAQA QGAAEPSRGP PLPSARGAPP SPEAGFATAD HSSQERETEK AMDRLARGTQ SIPNDSPARG EGTHSEEEGF AMDEEDSDGE LNTWELSEGT NCPPKEQPGD LFNEDWDSEL KADQGNPYDA DDIQESISQE LKPWVCCAPQ GDMIYDPSWH HPPPLIPYYS KMVFETGQFD DAED Sequence without tag. The proposed Purification-Tag is based on experiences with the expression system, a different complexity of the protein could make another tag necessary. In case you have a special request, please contact us.
- Specificity
- If you are looking for a specific domain and are interested in a partial protein or a different isoform, please contact us regarding an individual offer.
- Characteristics
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Key Benefits:
- Made to order protein - from design to production - by highly experienced protein experts.
- Protein expressed in mammalian cells and purified in one-step affinity chromatography
- The optimized expression system ensures reliability for intracellular, secreted and transmembrane proteins.
- State-of-the-art algorithm used for plasmid design (Gene synthesis).
If you are not interested in a full length protein, please contact us for individual protein fragments.
The big advantage of ordering our made-to-order proteins in comparison to ordering custom made proteins from other companies is that there is no financial obligation in case the protein cannot be expressed or purified. - Purity
- > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
- Grade
- custom-made
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- Application Notes
- We expect the protein to work for functional studies. As the protein has not been tested for functional studies yet we cannot offer a guarantee though.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- The buffer composition is at the discretion of the manufacturer.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -80 °C
- Storage Comment
- Store at -80°C.
- Expiry Date
- 12 months
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- Target
- COPRS (Coordinator of PRMT5, Differentiation Stimulator (COPRS))
- Alternative Name
- COPRS (COPRS Products)
- Background
- Coordinator of PRMT5 and differentiation stimulator (Cooperator of PRMT5) (Protein TTP1),FUNCTION: Histone-binding protein required for histone H4 methyltransferase activity of PRMT5. Specifically required for histone H4 'Arg-3' methylation mediated by PRMT5, but not histone H3 'Arg-8' methylation, suggesting that it modulates the substrate specificity of PRMT5. Specifically interacts with the N-terminus of histone H4 but not with histone H3, suggesting that it acts by promoting the association between histone H4 and PRMT5. Involved in CCNE1 promoter repression. Plays a role in muscle cell differentiation by modulating the recruitment of PRMT5 to the promoter of genes involved in the coordination between cell cycle exit and muscle differentiation (By similarity). {ECO:0000250, ECO:0000269|PubMed:18404153}.
- Molecular Weight
- 20.1 kDa
- UniProt
- Q9NQ92
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