INCA1 Protein (AA 1-236) (His tag)
custom-made
INCA1
Origin: Human
Host: HEK-293 Cells
Recombinant
> 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
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- Target See all INCA1 products
- INCA1 (Inhibitor of CDK, Cyclin A1 Interacting Protein 1 (INCA1))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 1-236
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Origin
- Human
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This INCA1 protein is labelled with His tag.
- Purpose
- Custom-made recombinant INCA1 Protein expressed in mammalian cells.
- Sequence
- MQVQDDGVNL IPFAKCSRVV SRSPPPRLPS QSLRPMPQRY GDVFWKNLNQ RPTPTWLEEQ HIPPMLRATG CSQLGLYPPE QLPPPEMLWR RKKRRPCLEG MQQQGLGGVP ARVRAVTYHL EDLRRRQSII NELKKAQWGS SGAASEPVVL GEEGCGFPST NEYPDLEEER ATYPQEEDRF LTPGRAQLLW SPWSPLDQEE ACASRQLHSL ASFSTVTARR NPLHNPWGME LAASEE Sequence without tag. The proposed Purification-Tag is based on experiences with the expression system, a different complexity of the protein could make another tag necessary. In case you have a special request, please contact us.
- Specificity
- If you are looking for a specific domain and are interested in a partial protein or a different isoform, please contact us regarding an individual offer.
- Characteristics
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Key Benefits:
- Made to order protein - from design to production - by highly experienced protein experts.
- Protein expressed in mammalian cells and purified in one-step affinity chromatography
- The optimized expression system ensures reliability for intracellular, secreted and transmembrane proteins.
- State-of-the-art algorithm used for plasmid design (Gene synthesis).
If you are not interested in a full length protein, please contact us for individual protein fragments.
The big advantage of ordering our made-to-order proteins in comparison to ordering custom made proteins from other companies is that there is no financial obligation in case the protein cannot be expressed or purified. - Purity
- > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
- Grade
- custom-made
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Inhibitor of CDK, Cyclin A1 Interacting Protein 1 (INCA1) (AA 1-231) protein (His tag)
custom-made INCA1 Origin: Mouse Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
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- Application Notes
- We expect the protein to work for functional studies. As the protein has not been tested for functional studies yet we cannot offer a guarantee though.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- The buffer composition is at the discretion of the manufacturer.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -80 °C
- Storage Comment
- Store at -80°C.
- Expiry Date
- 12 months
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- Target
- INCA1 (Inhibitor of CDK, Cyclin A1 Interacting Protein 1 (INCA1))
- Alternative Name
- INCA1 (INCA1 Products)
- Background
- Protein INCA1 (Inhibitor of CDK interacting with cyclin A1),FUNCTION: Binds to CDK2-bound cyclins and inhibits the kinase activity of CDK2, binding to cyclins is critical for its function as CDK inhibitor (PubMed:21540187). Inhibits cell growth and cell proliferation and may play a role in cell cycle control (By similarity). Required for ING5-mediated regulation of S-phase progression, enhancement of Fas-induced apoptosis and inhibition of cell growth (By similarity). {ECO:0000250|UniProtKB:Q6PKN7, ECO:0000269|PubMed:21540187}.
- Molecular Weight
- 26.8 kDa
- UniProt
- Q0VD86
- AlphaFold
- Q0VD86
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