ADCY10 Protein (AA 1-1610) (His tag)

Catalog No. ABIN7552063

Product Details

Target: ADCY10 (Adenylate Cyclase 10 (Soluble) (ADCY10))

Protein Type: Recombinant

Protein Characteristics: AA 1-1610

Origin: Human

Source: HEK-293 Cells

Purification tag / Conjugate: This ADCY10 protein is labelled with His tag.

Purpose: Custom-made recombinant ADCY10 Protein expressed in mammalian cells.

Sequence: MNTPKEEFQD WPIVRIAAHL PDLIVYGHFS PERPFMDYFD GVLMFVDISG FTAMTEKFSS AMYMDRGAEQ LVEILNYHIS AIVEKVLIFG GDILKFAGDA LLALWRVERK QLKNIITVVI KCSLEIHGLF ETQEWEEGLD IRVKIGLAAG HISMLVFGDE THSHFLVIGQ AVDDVRLAQN MAQMNDVILS PNCWQLCDRS MIEIESVPDQ RAVKVNFLKP PPNFNFDEFF TKCTTFMHYY PSGEHKNLLR LACTLKPDPE LEMSLQKYVM ESILKQIDNK QLQGYLSELR PVTIVFVNLM FEDQDKAEEI GPAIQDAYMH ITSVLKIFQG QINKVFMFDK GCSFLCVFGF PGEKVPDELT HALECAMDIF DFCSQVHKIQ TVSIGVASGI VFCGIVGHTV RHEYTVIGQK VNLAARMMMY YPGIVTCDSV TYNGSNLPAY FFKELPKKVM KGVADSGPLY QYWGRTEKVM FGMACLICNR KEDYPLLGRN KEINYFMYTM KKFLISNSSQ VLMYEGLPGY GKSQILMKIE YLAQGKNHRI IAISLNKISF HQTFYTIQMF MANVLGLDTC KHYKERQTNL RNKVMTLLDE KFYCLLNDIF HVQFPISREI SRMSTLKKQK QLEILFMKIL KLIVKEERII FIIDEAQFVD STSWRFMEKL IRTLPIFIIM SLCPFVNIPC AAARAVIKNR NTTYIVIGAV QPNDISNKIC LDLNVSCISK ELDSYLGEGS CGIPFYCEEL LKNLEHHEVL VFQQTESEEK TNRTWNNLFK YSIKLTEKLN MVTLHSDKES EEVCHLTSGV RLKNLSPPTS LKEISLIQLD SMRLSHQMLV RCAAIIGLTF TTELLFEILP CWNMKMMIKT LATLVESNIF YCFRNGKELQ KALKQNDPSF EVHYRSLSLK PSEGMDHGEE EQLRELENEV IECHRIRFCN PMMQKTAYEL WLKDQRKAMH LKCARFLEED AHRCDHCRGR DFIPYHHFTV NIRLNALDMD AIKKMAMSHG FKTEEKLILS NSEIPETSAF FPENRSPEEI REKILNFFDH VLTKMKTSDE DIIPLESCQC EEILEIVILP LAHHFLALGE NDKALYYFLE IASAYLIFCD NYMAYMYLNE GQKLLKTLKK DKSWSQTFES ATFYSLKGEV CFNMGQIVLA KKMLRKALKL LNRIFPYNLI SLFLHIHVEK NRHFHYVNRQ AQESPPPGKK RLAQLYRQTV CLSLLWRIYS YSYLFHCKYY AHLAVMMQMN TALETQNCFQ IIKAYLDYSL YHHLAGYKGV WFKYEVMAME HIFNLPLKGE GIEIVAYVAE TLVFNKLIMG HLDLAIELGS RALQMWALLQ NPNRHYQSLC RLSRCLLLNS RYPQLIQVLG RLWELSVTQE HIFSKAFFYF VCLDILLYSG FVYRTFEECL EFIHQYENNR ILKFHSGLLL GLYSSVAIWY ARLQEWDNFY KFSNRAKNLL PRRTMTLTYY DGISRYMEGQ VLHLQKQIKE QSENAQASGE ELLKNLENLV AQNTTGPVFC PRLYHLMAYV CILMGDGQKC GLFLNTALRL SETQGNILEK CWLNMNKESW YSTSELKEDQ WLQTILSLPS WEKIVAGRVN IQDLQKNKFL MRANTVDNHF Sequence without tag. The proposed Purification-Tag is based on experiences with the expression system, a different complexity of the protein could make another tag necessary. In case you have a special request, please contact us.

Specificity: If you are looking for a specific domain and are interested in a partial protein or a different isoform, please contact us regarding an individual offer.

Characteristics: Key Benefits:

• Made to order protein - from design to production - by highly experienced protein experts.
• Protein expressed in mammalian cells and purified in one-step affinity chromatography
• The optimized expression system ensures reliability for intracellular, secreted and transmembrane proteins.
• State-of-the-art algorithm used for plasmid design (Gene synthesis).

This protein is a made-to-order protein and will be made for the first time for your order. Our experts in the lab try to ensure that you receive soluble protein.

If you are not interested in a full length protein, please contact us for individual protein fragments.

The big advantage of ordering our made-to-order proteins in comparison to ordering custom made proteins from other companies is that there is no financial obligation in case the protein cannot be expressed or purified.

Purity: > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)

Grade: custom-made

Application Details

Application Notes: We expect the protein to work for functional studies. As the protein has not been tested for functional studies yet we cannot offer a guarantee though.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: The buffer composition is at the discretion of the manufacturer.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -80 °C

Storage Comment: Store at -80°C.

Expiry Date: 12 months

Target Details

Target: ADCY10 (Adenylate Cyclase 10 (Soluble) (ADCY10))

Alternative Name: ADCY10 (ADCY10 Products)

Background: Adenylate cyclase type 10 (EC 4.6.1.1) (AH-related protein) (Adenylate cyclase homolog) (Germ cell soluble adenylyl cyclase) (hsAC) (sAC) (Testicular soluble adenylyl cyclase),FUNCTION: Catalyzes the formation of the signaling molecule cAMP (PubMed:12609998, PubMed:15659711, PubMed:24616449, PubMed:25040695, PubMed:24567411). May function as sensor that mediates responses to changes in cellular bicarbonate and CO(2) levels (PubMed:15659711, PubMed:17591988). Has a critical role in mammalian spermatogenesis by producing the cAMP which regulates cAMP-responsive nuclear factors indispensable for sperm maturation in the epididymis. Induces capacitation, the maturational process that sperm undergo prior to fertilization (By similarity). Involved in ciliary beat regulation (PubMed:17591988). {ECO:0000250|UniProtKB:Q8C0T9, ECO:0000269|PubMed:15659711, ECO:0000269|PubMed:17591988, ECO:0000269|PubMed:24567411, ECO:0000269|PubMed:24616449, ECO:0000269|PubMed:25040695}.

Molecular Weight: 187.1 kDa

UniProt: Q96PN6

Pathways: cAMP Metabolic Process