KLF15 Protein (AA 1-416) (His tag)

Catalog No. ABIN7554314

Product Details

Target: KLF15 (Kruppel-Like Factor 15 (KLF15))

Protein Type: Recombinant

Protein Characteristics: AA 1-416

Origin: Human

Source: HEK-293 Cells

Purification tag / Conjugate: This KLF15 protein is labelled with His tag.

Purpose: Custom-made recombinant KLF15 Protein expressed in mammalian cells.

Sequence: MVDHLLPVDE NFSSPKCPVG YLGDRLVGRR AYHMLPSPVS EDDSDASSPC SCSSPDSQAL CSCYGGGLGT ESQDSILDFL LSQATLGSGG GSGSSIGASS GPVAWGPWRR AAAPVKGEHF CLPEFPLGDP DDVPRPFQPT LEEIEEFLEE NMEPGVKEVP EGNSKDLDAC SQLSAGPHKS HLHPGSSGRE RCSPPPGGAS AGGAQGPGGG PTPDGPIPVL LQIQPVPVKQ ESGTGPASPG QAPENVKVAQ LLVNIQGQTF ALVPQVVPSS NLNLPSKFVR IAPVPIAAKP VGSGPLGPGP AGLLMGQKFP KNPAAELIKM HKCTFPGCSK MYTKSSHLKA HLRRHTGEKP FACTWPGCGW RFSRSDELSR HRRSHSGVKP YQCPVCEKKF ARSDHLSKHI KVHRFPRSSR SVRSVN Sequence without tag. The proposed Purification-Tag is based on experiences with the expression system, a different complexity of the protein could make another tag necessary. In case you have a special request, please contact us.

Specificity: If you are looking for a specific domain and are interested in a partial protein or a different isoform, please contact us regarding an individual offer.

Characteristics: Key Benefits:

• Made to order protein - from design to production - by highly experienced protein experts.
• Protein expressed in mammalian cells and purified in one-step affinity chromatography
• The optimized expression system ensures reliability for intracellular, secreted and transmembrane proteins.
• State-of-the-art algorithm used for plasmid design (Gene synthesis).

This protein is a made-to-order protein and will be made for the first time for your order. Our experts in the lab try to ensure that you receive soluble protein.

If you are not interested in a full length protein, please contact us for individual protein fragments.

The big advantage of ordering our made-to-order proteins in comparison to ordering custom made proteins from other companies is that there is no financial obligation in case the protein cannot be expressed or purified.

Purity: > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)

Grade: custom-made

Application Details

Application Notes: We expect the protein to work for functional studies. As the protein has not been tested for functional studies yet we cannot offer a guarantee though.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: The buffer composition is at the discretion of the manufacturer.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -80 °C

Storage Comment: Store at -80°C.

Expiry Date: 12 months

Target Details

Target: KLF15 (Kruppel-Like Factor 15 (KLF15))

Alternative Name: KLF15 (KLF15 Products)

Background: Krueppel-like factor 15 (Kidney-enriched krueppel-like factor),FUNCTION: Transcriptional regulator that binds to the GA element of the CLCNKA promoter. Binds to the KCNIP2 promoter and regulates KCNIP2 circadian expression in the heart (By similarity). Is a repressor of CCN2 expression, involved in the control of cardiac fibrosis. It is also involved in the control of cardiac hypertrophy acting through the inhibition of MEF2A and GATA4 (By similarity). Involved in podocyte differentiation (By similarity). Inhibits MYOCD activity. Is a negative regulator of TP53 acetylation. Inhibits NF-kappa-B activation through repression of EP300-dependent RELA acetylation. {ECO:0000250, ECO:0000269|PubMed:18586263, ECO:0000269|PubMed:20375365, ECO:0000269|PubMed:20566642, ECO:0000269|PubMed:23999430}.

Molecular Weight: 44.0 kDa

UniProt: Q9UIH9