PHC3 Protein (AA 1-983) (His tag)

Catalog No. ABIN7554985

Product Details

Target: PHC3 (Polyhomeotic Homolog 3 (PHC3))

Protein Type: Recombinant

Protein Characteristics: AA 1-983

Origin: Human

Source: HEK-293 Cells

Purification tag / Conjugate: This PHC3 protein is labelled with His tag.

Purpose: Custom-made recombinant PHC3 Protein expressed in mammalian cells.

Sequence: MDTEPNPGTS SVSTTTSSTT TTTITTSSSR MQQPQISVYS GSDRHAVQVI QQALHRPPSS AAQYLQQMYA AQQQHLMLHT AALQQQHLSS SQLQSLAAVQ ASLSSGRPST SPTGSVTQQS SMSQTSINLS TSPTPAQLIS RSQASSSTSG SITQQTMLLG STSPTLTASQ AQMYLRAQML IFTPATTVAA VQSDIPVVSS SSSSSCQSAA TQVQNLTLRS QKLGVLSSSQ NGPPKSTSQT QSLTICHNKT TVTSSKISQR DPSPESNKKG ESPSLESRST AVTRTSSIHQ LIAPASYSPI QPHSLIKHQQ IPLHSPPSKV SHHQLILQQQ QQQIQPITLQ NSTQDPPPSQ HCIPLQNHGL PPAPSNAQSQ HCSPIQSHPS PLTVSPNQSQ SAQQSVVVSP PPPHSPSQSP TIIIHPQALI QPHPLVSSAL QPGPNLQQST ANQVQATAQL NLPSHLPLPA SPVVHIGPVQ QSALVSPGQQ IVSPSHQQYS SLQSSPIPIA SPPQMSTSPP AQIPPLPLQS MQSLQVQPEI LSQGQVLVQN ALVSEEELPA AEALVQLPFQ TLPPPQTVAV NLQVQPPAPV DPPVVYQVED VCEEEMPEES DECVRMDRTP PPPTLSPAAI TVGRGEDLTS EHPLLEQVEL PAVASVSASV IKSPSDPSHV SVPPPPLLLP AATTRSNSTS MHSSIPSIEN KPPQAIVKPQ ILTHVIEGFV IQEGLEPFPV SRSSLLIEQP VKKRPLLDNQ VINSVCVQPE LQNNTKHADN SSDTEMEDMI AEETLEEMDS ELLKCEFCGK MGYANEFLRS KRFCTMSCAK RYNVSCSKKF ALSRWNRKPD NQSLGHRGRR PSGPDGAARE HILRQLPITY PSAEEDLASH EDSVPSAMTT RLRRQSERER ERELRDVRIR KMPENSDLLP VAQTEPSIWT VDDVWAFIHS LPGCQDIADE FRAQEIDGQA LLLLKEDHLM SAMNIKLGPA LKICARINSL KES Sequence without tag. The proposed Purification-Tag is based on experiences with the expression system, a different complexity of the protein could make another tag necessary. In case you have a special request, please contact us.

Specificity: If you are looking for a specific domain and are interested in a partial protein or a different isoform, please contact us regarding an individual offer.

Characteristics: Key Benefits:

• Made to order protein - from design to production - by highly experienced protein experts.
• Protein expressed in mammalian cells and purified in one-step affinity chromatography
• The optimized expression system ensures reliability for intracellular, secreted and transmembrane proteins.
• State-of-the-art algorithm used for plasmid design (Gene synthesis).

This protein is a made-to-order protein and will be made for the first time for your order. Our experts in the lab try to ensure that you receive soluble protein.

If you are not interested in a full length protein, please contact us for individual protein fragments.

The big advantage of ordering our made-to-order proteins in comparison to ordering custom made proteins from other companies is that there is no financial obligation in case the protein cannot be expressed or purified.

Purity: > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)

Grade: custom-made

Application Details

Application Notes: We expect the protein to work for functional studies. As the protein has not been tested for functional studies yet we cannot offer a guarantee though.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: The buffer composition is at the discretion of the manufacturer.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -80 °C

Storage Comment: Store at -80°C.

Expiry Date: 12 months

Target Details

Target: PHC3 (Polyhomeotic Homolog 3 (PHC3))

Alternative Name: PHC3 (PHC3 Products)

Background: Polyhomeotic-like protein 3 (Early development regulatory protein 3) (Homolog of polyhomeotic 3) (hPH3),FUNCTION: Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. {ECO:0000269|PubMed:12167701}.

Molecular Weight: 106.2 kDa

UniProt: Q8NDX5