Zinc Finger, BED-Type Containing 6 (ZBED6) (AA 1-979) protein (His tag)
custom-made
ZBED6
Origin: Human
Host: HEK-293 Cells
Recombinant
> 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
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- Target See all Zinc Finger, BED-Type Containing 6 (ZBED6) products
- Zinc Finger, BED-Type Containing 6 (ZBED6)
- Protein Type
- Recombinant
- Protein Characteristics
- AA 1-979
- Origin
- Human
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- His tag
- Purpose
- Made-to-order recombinant ZBED6 Protein expressed in mammalian cells.
- Sequence
- MSVCTLSVPV SSLSPGRRCN TFSDSGILGC VPINSNTDEE DVVEEKMVAE GVNKEAKQPA KKKRKKGLRI KGKRRRKKLI LAKKFSKDLG SGRPVADAPA LLASNDPEQD EESLFESNIE KQIYLPSTRA KTSIVWHFFH VDPQYTWRAI CNLCEKSVSR GKPGSHLGTS TLQRHLQARH SPHWTRANKF GVASGEEDFT LDVSLSPSSG SNGSFEYIPT DPLDDNRMGK KHDKSASDAL RAERGRFLIK SNIVKHALIP GTRAKTSAVW NFFYTDPQHI SRAVCNICKR SVSRGRPGSH LGTSTLQRHL QATHPIHWAV ANKDSGAVAN GLDEAETERS DLLSDTLHGE KSTGSQDLTA EDLSDSDSDE PMLEVENRSE SPIPVAEQGT LMRAQERETT CCGNPVSSHI SQAIIQMIVE DMHPYNYFST PAFQRFMQIV APDYRLPSET YFFTKAVPQL YDCVREKIFL TLENVQSQKI HLTVDIWTHD PSTDYFIVTV HWVSLETASF LNNGRIPDFR KWAVLCVTGL AKDCLITNIL QELNDQIGLW LSPNFLIPSF IVSDNSSNVV HAIKDGGFTH VPCFLHCLNM VIQDFFCEHK SIENMLVAAR KTCHHFSHSV KARQILQEFQ NDHQLPWKNL KQDETGHWIS TFYMLKWLLE HCYSVHHSLG RASGVVLTSL QWTLMTYVCD ILKPFEEATQ KVSVKTAGLN QVLPLIHHLL LSLQKLREDF QVRGITQALN LVDSLSLKLE TDTLLSAMLK SKPCILATLL DPCFKNSLED FFPQGADLET YKQFLAEEVC NYMESSPEIC QIPTSEASCP SVTVGADSFT SSLKEGTSSS GSVDSSAVDN VALGSKSFMF PSAVAVVDEY FKEKYSEFSG GDDPLIYWQR KISIWPALTQ VAIQYLSCPM CSWQSECIFT KNSHFHPKQI MSLDFDNIEQ LMFLKMNLKN VNYDYSTLVL SWDPEQNEVV QSSEKEILP Sequence without tag. The proposed Purification-Tag is based on experiences with the expression system, a different complexity of the protein could make another tag necessary. In case you have a special request, please contact us.
- Specificity
- If you are looking for a specific domain and are interested in a partial protein or a different isoform, please contact us regarding an individual offer.
- Characteristics
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Key Benefits:
- Made to order protein - from design to production - by highly experienced protein experts.
- Protein expressed in mammalian cells and purified in one-step affinity chromatography
- The optimized expression system ensures reliability for intracellular, secreted and transmembrane proteins.
- State-of-the-art algorithm used for plasmid design (Gene synthesis).
If you are not interested in a full length protein, please contact us for individual protein fragments.
The big advantage of ordering our made-to-order proteins in comparison to ordering custom made proteins from other companies is that there is no financial obligation in case the protein cannot be expressed or purified. - Purity
- > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
- Grade
- custom-made
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- Application Notes
- We expect the protein to work for functional studies. As the protein has not been tested for functional studies yet we cannot offer a guarantee though.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- The buffer composition is at the discretion of the manufacturer.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -80 °C
- Storage Comment
- Store at -80°C.
- Expiry Date
- 12 months
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- Target
- Zinc Finger, BED-Type Containing 6 (ZBED6)
- Alternative Name
- ZBED6 (ZBED6 Products)
- Background
- Zinc finger BED domain-containing protein 6,FUNCTION: Transcriptional repressor which binds to the consensus sequence 5'-GCTCGC-3', transcription regulation may be tissue-specific (By similarity). Regulates the expression of target genes such as: IGF2, PGAP6/TMEM8, ENHO, and PIANP (By similarity). Acts as a transcriptional repressor of growth factor IGF2, thereby negatively regulating postnatal growth of muscles and internal organs, especially in females (By similarity). Negatively regulates myoblast differentiation and myoblast mitochondrial activity via its regulation of IGF2 transcription (By similarity). Negatively regulates the cell cycle of myoblasts, potentially via transcriptional regulation of the E2F family of transcription factors such as: E2F1 and E2F2 (By similarity). Positively regulates the cell cycle and survival of pancreatic beta cells (PubMed:24043816). Binds to the CDH2 gene and may directly repress CDH2 transcription (By similarity). Probably by controlling CDH2 expression, regulates pancreatic beta cell adhesion, and formation of cell-to-cell junctions between pancreatic beta cells and neural crest stem cells (By similarity). May also play a role in embryonic beta cell differentiation (By similarity). May play a role in insulin sensitivity and glucose clearance (By similarity). {ECO:0000250|UniProtKB:D2EAC2, ECO:0000269|PubMed:24043816}.
- Molecular Weight
- 110.0 kDa
- UniProt
- P86452
- AlphaFold
- P86452
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