MTMR12 Protein (AA 1-747) (His tag)

Catalog No. ABIN7558317

Product Details

Target: MTMR12 (Myotubularin Related Protein 12 (MTMR12))

Protein Type: Recombinant

Protein Characteristics: AA 1-747

Origin: Mouse

Source: HEK-293 Cells

Purification tag / Conjugate: This MTMR12 protein is labelled with His tag.

Purpose: Made-to-order recombinant Mtmr12 Protein expressed in mammalian cells.

Sequence: MLGKGGVGGG GGTKAPKPSF VSYVRPEEIH TDEKEVTEKE VTLHLLPGEQ LLCEASTVLK YVQEDSCQRG VYGRLVCTDF KISFLGDEDS ALDNGGEAQF KNKIIGVNDV PLHCVDQIYG VFDEKKKPLF GQLKKYPEKL VIHCKDLRVL HFCLRYTKEE EVKRIVSGII HHTQSPKLLK RLFLFSYAAA VHGTATDSRN CTVMFDTPKD WCWELERTKG SVKYRTVSVN EGYRVSDRLP AYFVVPTPLP EDDVRRFQGH GIPIWCWSCH NGSALLKMSA LPKEQDDGAL QVQKSFLDGI YKTIHRPPYE MVKTEDLSSN FLSLQEIQSA YCKFKQLFLI DNSSEFWDTD IKWFSLLESS SWLDIIRRCL KKAIEITECL EAQNVNVLLL EENASDLCCL LSSLVQVMMD AHCRTRTGFQ SLIQKEWVMG GHSFLDRCNH LHQSDKEEVP IFLLFLDCVW QLVHQYPPAF EFTETYLTVL SDSLYIPIFS TFFFNSPHQK DTNMGRENLD AQSKPLTLLT VWDWSVQFEP KAQTLLRNPL YVEKPKLDRG QQKGSRFKHQ RQLSLPLTQS KSSPKRGFFR EETDHLIKNL LGKRISKLIN SSDDLQDSSR EFYDSWHSKP TDYHGLLLPH IEGPEIKVWA QRYLRWIPEA QILGGGRVAT MGKLLEMMEE VQSLQEKIEA RHHRQEAVHA EAPGLLRNSV RLSSLFPFAL LQRHSAKPVL PTSGWKALGG EDDLAKREDE FVDLGDV Sequence without tag. The proposed Purification-Tag is based on experiences with the expression system, a different complexity of the protein could make another tag necessary. In case you have a special request, please contact us.

Specificity: If you are looking for a specific domain and are interested in a partial protein or a different isoform, please contact us regarding an individual offer.

Characteristics: Key Benefits:

• Made to order protein - from design to production - by highly experienced protein experts.
• Protein expressed in mammalian cells and purified in one-step affinity chromatography
• The optimized expression system ensures reliability for intracellular, secreted and transmembrane proteins.
• State-of-the-art algorithm used for plasmid design (Gene synthesis).

This protein is a made-to-order protein and will be made for the first time for your order. Our experts in the lab try to ensure that you receive soluble protein.

If you are not interested in a full length protein, please contact us for individual protein fragments.

The big advantage of ordering our made-to-order proteins in comparison to ordering custom made proteins from other companies is that there is no financial obligation in case the protein cannot be expressed or purified.

Purity: > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)

Grade: custom-made

Application Details

Application Notes: We expect the protein to work for functional studies. As the protein has not been tested for functional studies yet we cannot offer a guarantee though.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: The buffer composition is at the discretion of the manufacturer.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -80 °C

Storage Comment: Store at -80°C.

Expiry Date: 12 months

Target Details

Target: MTMR12 (Myotubularin Related Protein 12 (MTMR12))

Alternative Name: Mtmr12 (MTMR12 Products)

Background: Myotubularin-related protein 12 (Inactive phosphatidylinositol 3-phosphatase 12),FUNCTION: Acts as an adapter for the myotubularin-related phosphatases (PubMed:23818870). Regulates phosphatase MTM1 protein stability and possibly its intracellular location (PubMed:23818870). By stabilizing MTM1 protein levels, required for skeletal muscle maintenance but not for myogenesis (PubMed:23818870). {ECO:0000269|PubMed:23818870}.

Molecular Weight: 85.5 kDa

UniProt: Q80TA6

AlphaFold: Q80TA6