HEXIM1 Protein (AA 1-356) (His tag)
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- Target See all HEXIM1 Proteins
- HEXIM1 (Hexamethylene Bis-Acetamide Inducible 1 (HEXIM1))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 1-356
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Origin
- Mouse
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This HEXIM1 protein is labelled with His tag.
- Purpose
- Custom-made recombinant Hexim1 Protein expressed in mammalian cells.
- Sequence
- MAEPLLTEHQ HQPQTSNCTG AAVVHEEHTS ERPPSAEERV PKEDSRWQSR ASLQSGSRPG QEGEGGLKHQ LPPLQTNACP ELSSLEKGEK GQNGEDLSTG GASPSAEGEP MSESLVQPGH DSEATKQEAP AAGGEEPWGQ QQRQLGKKKH RRRPSKKKRH WKPYYKLTWE EKKKFDEKQS LRASRVRAEM FAKGQPVAPY NTTQFLMDDH DQEEPDLKTG LYPKRAAAKS DDTSDEDFVE EAGEEDGGSD GMGGDGSEFL QRDFSETYER YHAESLQNMS KQELIKEYLE LEKCLSRKED ENNRLRLESK RLGGVDARVR ELELELDRLR AENLQLLTEN ELHRQQERAP LSKFGD Sequence without tag. The proposed Purification-Tag is based on experiences with the expression system, a different complexity of the protein could make another tag necessary. In case you have a special request, please contact us.
- Specificity
- If you are looking for a specific domain and are interested in a partial protein or a different isoform, please contact us regarding an individual offer.
- Characteristics
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Key Benefits:
- Made to order protein - from design to production - by highly experienced protein experts.
- Protein expressed in mammalian cells and purified in one-step affinity chromatography
- The optimized expression system ensures reliability for intracellular, secreted and transmembrane proteins.
- State-of-the-art algorithm used for plasmid design (Gene synthesis).
If you are not interested in a full length protein, please contact us for individual protein fragments.
The big advantage of ordering our made-to-order proteins in comparison to ordering custom made proteins from other companies is that there is no financial obligation in case the protein cannot be expressed or purified. - Purity
- > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
- Grade
- custom-made
- Top Product
- Discover our top product HEXIM1 Protein
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Hexamethylene Bis-Acetamide Inducible 1 (HEXIM1) (AA 1-359) protein (His tag)
custom-made HEXIM1 Origin: Human Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Hexamethylene Bis-Acetamide Inducible 1 (HEXIM1) (AA 1-359) protein (His tag)HEXIM1 Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 95 % as determined by SDS-PAGE ELISA, WB
Hexamethylene Bis-Acetamide Inducible 1 (HEXIM1) (AA 1-359) protein (GST tag)HEXIM1 Origin: Human Host: Wheat germ Recombinant ELISA, WB, AP, AA
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- Application Notes
- We expect the protein to work for functional studies. As the protein has not been tested for functional studies yet we cannot offer a guarantee though.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- The buffer composition is at the discretion of the manufacturer.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -80 °C
- Storage Comment
- Store at -80°C.
- Expiry Date
- 12 months
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- Target
- HEXIM1 (Hexamethylene Bis-Acetamide Inducible 1 (HEXIM1))
- Alternative Name
- Hexim1 (HEXIM1 Products)
- Background
- Protein HEXIM1 (Cardiac lineage protein 1),FUNCTION: Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor. Core component of the 7SK RNP complex: in cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation. May also regulate NF-kappa-B, ESR1, NR3C1 and CIITA-dependent transcriptional activity. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway. {ECO:0000250|UniProtKB:O94992}.
- Molecular Weight
- 40.2 kDa
- UniProt
- Q8R409
- AlphaFold
- Q8R409
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