PPAPDC2 Protein (AA 1-292) (His tag)

Catalog No. ABIN7560987

Product Details

Target: PPAPDC2 (Phosphatidic Acid Phosphatase Type 2 Domain Containing 2 (PPAPDC2))

Protein Type: Recombinant

Protein Characteristics: AA 1-292

Origin: Mouse

Source: HEK-293 Cells

Purification tag / Conjugate: This PPAPDC2 protein is labelled with His tag.

Purpose: Custom-made recombinant Plpp6 Protein expressed in mammalian cells.

Sequence: MPSPRRTIEG RPLGSSGGSS VPGSPAHGGG SGGGRFEFQS LLNCRAGADP ACARLRASDS PVHRRGSFPL AASGPAQAAP APPPEDARMN LNPSFLGIAL RSLLAIDLWL SKKLGVCAGE SSAWGSVRPL MKLLEISGHG IPWLLGTLYC LLRSDSWAGR EVLMNLLFAL LLDLLLVAVI KGLVRRRRPA HNQKDMFFTL SVDRYSFPSG HATRAALVSR FILNHLVLAI PLRVLVVLWA FVLGLSRVML GRHNVTDVAF GFFLGYMQYS IVDYCWLSPH NVPVLFVLWN QQ Sequence without tag. The proposed Purification-Tag is based on experiences with the expression system, a different complexity of the protein could make another tag necessary. In case you have a special request, please contact us.

Specificity: If you are looking for a specific domain and are interested in a partial protein or a different isoform, please contact us regarding an individual offer.

Characteristics: Key Benefits:

• Made to order protein - from design to production - by highly experienced protein experts.
• Protein expressed in mammalian cells and purified in one-step affinity chromatography
• The optimized expression system ensures reliability for intracellular, secreted and transmembrane proteins.
• State-of-the-art algorithm used for plasmid design (Gene synthesis).

This protein is a made-to-order protein and will be made for the first time for your order. Our experts in the lab try to ensure that you receive soluble protein.

If you are not interested in a full length protein, please contact us for individual protein fragments.

The big advantage of ordering our made-to-order proteins in comparison to ordering custom made proteins from other companies is that there is no financial obligation in case the protein cannot be expressed or purified.

Purity: > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)

Grade: custom-made

Application Details

Application Notes: We expect the protein to work for functional studies. As the protein has not been tested for functional studies yet we cannot offer a guarantee though.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: The buffer composition is at the discretion of the manufacturer.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -80 °C

Storage Comment: Store at -80°C.

Expiry Date: 12 months

Target Details

Target: PPAPDC2 (Phosphatidic Acid Phosphatase Type 2 Domain Containing 2 (PPAPDC2))

Alternative Name: Plpp6 (PPAPDC2 Products)

Background: Polyisoprenoid diphosphate/phosphate phosphohydrolase PLPP6 (EC 3.1.3.-) (EC 3.6.1.-) (EC 3.6.1.68) (Phospholipid phosphatase 6),FUNCTION: Magnesium-independent polyisoprenoid diphosphatase that catalyzes the sequential dephosphorylation of presqualene, farnesyl, geranyl and geranylgeranyl diphosphates. Functions in the innate immune response through the dephosphorylation of presqualene diphosphate which acts as a potent inhibitor of the signaling pathways contributing to polymorphonuclear neutrophils activation. May regulate the biosynthesis of cholesterol and related sterols by dephosphorylating presqualene and farnesyl diphosphate, two key intermediates in this biosynthetic pathway. May also play a role in protein prenylation by acting on farnesyl diphosphate and its derivative geranylgeranyl diphosphate, two precursors for the addition of isoprenoid anchors to membrane proteins. Has a lower activity towards phosphatidic acid (PA), but through phosphatidic acid dephosphorylation may participate in the biosynthesis of phospholipids and triacylglycerols. May also act on ceramide-1-P, lysophosphatidic acid (LPA) and sphing-4-enine 1-phosphate/sphingosine-1-phosphate. {ECO:0000250|UniProtKB:Q8IY26}.

Molecular Weight: 31.7 kDa

UniProt: Q9D4F2

AlphaFold: Q9D4F2