SLC22A17 Protein (AA 1-401) (His tag)
custom-made
SLC22A17
Origin: Mouse
Host: HEK-293 Cells
Recombinant
> 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
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- Target See all SLC22A17 Proteins
- SLC22A17 (Solute Carrier Family 22 (Organic Cation Transporter), Member 17 (SLC22A17))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 1-401
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Origin
- Mouse
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This SLC22A17 protein is labelled with His tag.
- Purpose
- Custom-made recombinant Slc22a17 Protein expressed in mammalian cells.
- Sequence
- MPSARFGRRG IVLLTLGLVG PCGVGGAAAG SSTGIMALRF LLGFLLAGVD LGVYLMRLEL CDPTQRLRVA LAGELVGVGG HFLFLGLALV SKDWRFLQRM ITAPCILFLF YGWPGLFLES ARWLIVKRQI EEAQSVLRIL AERNRPHGQM LGEEAQEALQ ELENTCPLPA TSTFSFASLL NYRNIWKNLL ILGFTNFIAH AIRHCYQPVG GGGSPSDFYL CSLLASGTAA LACVFLGVTV DRFGRRGILL LSMTLTGIAS LVLLGLWDYL NDAAITTFSV LGLFSSQASA ILSTLLASEV IPTTVRGRGL GLIMALGALG GLSCPAQRLH MGHGAFLQHV VLAACALLCI LSIMLLPETK RKLLPEVLRD GELCRRPSLL RQPPPNRCDH VPLLATPNPA L Sequence without tag. The proposed Purification-Tag is based on experiences with the expression system, a different complexity of the protein could make another tag necessary. In case you have a special request, please contact us.
- Specificity
- If you are looking for a specific domain and are interested in a partial protein or a different isoform, please contact us regarding an individual offer.
- Characteristics
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Key Benefits:
- Made to order protein - from design to production - by highly experienced protein experts.
- Protein expressed in mammalian cells and purified in one-step affinity chromatography
- The optimized expression system ensures reliability for intracellular, secreted and transmembrane proteins.
- State-of-the-art algorithm used for plasmid design (Gene synthesis).
If you are not interested in a full length protein, please contact us for individual protein fragments.
The big advantage of ordering our made-to-order proteins in comparison to ordering custom made proteins from other companies is that there is no financial obligation in case the protein cannot be expressed or purified. - Purity
- > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
- Grade
- custom-made
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Solute Carrier Family 22 (Organic Cation Transporter), Member 17 (SLC22A17) (AA 1-538) protein (GST tag)
SLC22A17 Origin: Human Host: Wheat germ Recombinant AP, ELISA, WB, AA
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- Application Notes
- We expect the protein to work for functional studies. As the protein has not been tested for functional studies yet we cannot offer a guarantee though.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- The buffer composition is at the discretion of the manufacturer.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -80 °C
- Storage Comment
- Store at -80°C.
- Expiry Date
- 12 months
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- Target
- SLC22A17 (Solute Carrier Family 22 (Organic Cation Transporter), Member 17 (SLC22A17))
- Alternative Name
- Slc22a17 (SLC22A17 Products)
- Background
- Solute carrier family 22 member 17 (24p3 receptor) (24p3R) (Brain-type organic cation transporter) (Lipocalin-2 receptor),FUNCTION: Cell surface receptor for LCN2 (24p3) that plays a key role in iron homeostasis and transport. Able to bind iron-bound LCN2 (holo-24p3), followed by internalization of holo-24p3 and release of iron, thereby increasing intracellular iron concentration and leading to inhibition of apoptosis. Also binds iron-free LCN2 (apo-24p3), followed by internalization of apo-24p3 and its association with an intracellular siderophore, leading to iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration and resulting in apoptosis. {ECO:0000269|PubMed:16377569}.
- Molecular Weight
- 43.2 kDa
- UniProt
- Q9D9E0
- AlphaFold
- Q9D9E0
- Pathways
- Transition Metal Ion Homeostasis
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