ZFYVE19 Protein (AA 1-389) (His tag)

Catalog No. ABIN7561249

Product Details

Target: ZFYVE19 (Zinc Finger, FYVE Domain Containing 19 (ZFYVE19))

Protein Type: Recombinant

Protein Characteristics: AA 1-389

Origin: Mouse

Source: HEK-293 Cells

Purification tag / Conjugate: This ZFYVE19 protein is labelled with His tag.

Purpose: Custom-made recombinant Zfyve19 Protein expressed in mammalian cells.

Sequence: MESRCYGCAV KFTLFKKEYG CKNCGRAFCN GCLSFSALVP RAGNTQQKVC KQCHTILTRG SSDNASKWSP PQNYKKRVAA LEAKKKSSTS HSQSLTHKDQ AIAERLARLR QENKPKSVPS QAEIEARLAA LKDEVQGPIP STQEMEDRLA ALQGRVPPSH TVRPAHQAPD TRTQAQQTQD LLTQLTAEVA IDENCQPRAS ASLQNDLNKG AARSQRTNSQ GQASQSLEEE KYKLLAEAAV ELQEENTRQE RILALAKRLA VLKGQDPSRV TLQDYHLPDS DEDEETAIQR VMQQLTEEAA LDEASGFNIP EKPAPGSRAQ PCKAEMEGPQ AEEEELPWCC ICNEDATLRC AGCDGDLYCA RCFREGHDNF DLKEHQTSPY HPRRPCQEH Sequence without tag. The proposed Purification-Tag is based on experiences with the expression system, a different complexity of the protein could make another tag necessary. In case you have a special request, please contact us.

Specificity: If you are looking for a specific domain and are interested in a partial protein or a different isoform, please contact us regarding an individual offer.

Characteristics: Key Benefits:

• Made to order protein - from design to production - by highly experienced protein experts.
• Protein expressed in mammalian cells and purified in one-step affinity chromatography
• The optimized expression system ensures reliability for intracellular, secreted and transmembrane proteins.
• State-of-the-art algorithm used for plasmid design (Gene synthesis).

This protein is a made-to-order protein and will be made for the first time for your order. Our experts in the lab try to ensure that you receive soluble protein.

If you are not interested in a full length protein, please contact us for individual protein fragments.

The big advantage of ordering our made-to-order proteins in comparison to ordering custom made proteins from other companies is that there is no financial obligation in case the protein cannot be expressed or purified.

Purity: > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)

Grade: custom-made

Application Details

Application Notes: We expect the protein to work for functional studies. As the protein has not been tested for functional studies yet we cannot offer a guarantee though.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: The buffer composition is at the discretion of the manufacturer.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -80 °C

Storage Comment: Store at -80°C.

Expiry Date: 12 months

Target Details

Target: ZFYVE19 (Zinc Finger, FYVE Domain Containing 19 (ZFYVE19))

Alternative Name: Zfyve19 (ZFYVE19 Products)

Background: Abscission/NoCut checkpoint regulator (ANCHR) (Zinc finger FYVE domain-containing protein 19),FUNCTION: Key regulator of abscission step in cytokinesis: part of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage. Together with CHMP4C, required to retain abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis. Deactivation of AURKB results in dephosphorylation of CHMP4C followed by its dissociation from ZFYVE19/ANCHR and VPS4 and subsequent abscission (By similarity). {ECO:0000250}.

Molecular Weight: 43.3 kDa

UniProt: Q9DAZ9