SLC6A12 Protein (AA 1-614) (His tag)

Catalog No. ABIN7563122

Product Details

Target: SLC6A12 (Solute Carrier Family 6 (Neurotransmitter Transporter, Betaine/GABA), Member 12 (SLC6A12))

Protein Type: Recombinant

Protein Characteristics: AA 1-614

Origin: Mouse

Source: HEK-293 Cells

Purification tag / Conjugate: This SLC6A12 protein is labelled with His tag.

Purpose: Custom-made recombinant Slc6a12 Protein expressed in mammalian cells.

Sequence: MDRKVAVHED GYPVVSWVPE EGEMMDQKGK DQVKDRGQWT NKMEFVLSVA GEIIGLGNVW RFPYLCYKNG GGAFFIPYFI FFFSCGIPVF FLEVALGQYS SQGSVTAWRK ICPLLQGIGM ASVVIESYLN IYYIIILAWA LFYLFSSFTW ELPWTTCTNS WNTEHCVDFL NHSSARGVSS SENFTSPVME FWERRVLGIT SGIHDLGSLR WELALCLLLA WIICYFCIWK GVKSTGKVVY FTATFPYLML IILLIRGVTL PGAYQGIVFY LKPDLLRLKD PQVWMDAGTQ IFFSFAICQG CLTALGSYNK YHNNCYRDSI ALCFLNSATS FVAGFVVFSI LGFMSQEQGI PISEVAESGP GLAFIAFPKA VTMMPLSQLW SCLFFIMLLF LGLDSQFVCM ECLVTASMDM FPQQLRKSGR RDVLILAISV LCYLMGLLLV TEGGMYIFQL FDYYASSGIC LLFLSLFEVI CIGWVYGADR FYDNVEDMIG YRPWPLVKIS WLFLTPGLCL ATFFFSLSKY TPLKYNNVYM YPSWGYSIGW LLAFSSMACV PLFIIITFLK TQGSFKKRLR RLITPDPSLP QPGRRPPQDG SSAQNCSSSP AKQELIAWEK ETHL Sequence without tag. The proposed Purification-Tag is based on experiences with the expression system, a different complexity of the protein could make another tag necessary. In case you have a special request, please contact us.

Specificity: If you are looking for a specific domain and are interested in a partial protein or a different isoform, please contact us regarding an individual offer.

Characteristics: Key Benefits:

• Made to order protein - from design to production - by highly experienced protein experts.
• Protein expressed in mammalian cells and purified in one-step affinity chromatography
• The optimized expression system ensures reliability for intracellular, secreted and transmembrane proteins.
• State-of-the-art algorithm used for plasmid design (Gene synthesis).

This protein is a made-to-order protein and will be made for the first time for your order. Our experts in the lab try to ensure that you receive soluble protein.

If you are not interested in a full length protein, please contact us for individual protein fragments.

The big advantage of ordering our made-to-order proteins in comparison to ordering custom made proteins from other companies is that there is no financial obligation in case the protein cannot be expressed or purified.

Purity: > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)

Grade: custom-made

Application Details

Application Notes: We expect the protein to work for functional studies. As the protein has not been tested for functional studies yet we cannot offer a guarantee though.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: The buffer composition is at the discretion of the manufacturer.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -80 °C

Storage Comment: Store at -80°C.

Expiry Date: 12 months

Target Details

Target: SLC6A12 (Solute Carrier Family 6 (Neurotransmitter Transporter, Betaine/GABA), Member 12 (SLC6A12))

Alternative Name: Slc6a12 (SLC6A12 Products)

Background: Sodium- and chloride-dependent betaine transporter (BGT-1) (Na(+)/Cl(-) betaine/GABA transporter) (Sodium- and chloride-dependent GABA transporter 2) (GAT-2) (Solute carrier family 6 member 12),FUNCTION: Transporter that mediates cellular uptake of betaine and GABA in a sodium- and chloride-dependent process (By similarity). May have a role in regulation of GABAergic transmission in the brain through the reuptake of GABA into presynaptic terminals, as well as in osmotic regulation (Probable). Probably also involved in renal and hepatic osmotic regulation (PubMed:22071246). {ECO:0000250|UniProtKB:P48065, ECO:0000305|PubMed:22071246}.

Molecular Weight: 69.6 kDa

UniProt: P31651