SYNM Protein (AA 1-1561) (His tag)

Catalog No. ABIN7564176

Product Details

Target: SYNM (Synemin, Intermediate Filament Protein (SYNM))

Protein Type: Recombinant

Protein Characteristics: AA 1-1561

Origin: Mouse

Source: HEK-293 Cells

Purification tag / Conjugate: This SYNM protein is labelled with His tag.

Purpose: Made-to-order recombinant Synm Protein expressed in mammalian cells.

Sequence: MLSWRLQTGS EKAELQELNA RLYDYVCRVR ELERENLLLE EELRSRLSRE DRWAEDQALY AEEARSLRQQ LDELNWSTAL AEGERDALRR ELLELQREGV EAGTARSRLD AELGAQRREL EEALGARAAL EALLGRLETE RRDLDAAHER QVRDLRARAA SLTMHFRARA TSPAAPPPRL RDVHDSYALL VAESWRESVQ LYEDEVRELE QALRRGQESR LQAEDEARLC AQEADALRNQ ALELEQLRAR LEDELLRMRE EYGMQAEERQ RVIDSLEDEK EALTLAMADR LRDYQELLQV KTGLSLEVAT YRALLEGESN PEILIWTENI ENVPQEPRNT SYRYTNSVLQ RKNEKNLFPR RKTPWAAVNH SSASYSNWPG HLDSQTTTAV GSAARRGLLT SRHSSSATTS GQQKPLEKTI SSRANLRPVT PTHGFLRNTD AQMKTLPHRS KVEGTGDTHA RRATESVITR ESYRGHQGHV AAGAVSSTPS NERTVILGKK LEAQATKEQE RDRSGVIRIK PEEKMFDSKE KASEERNLRW EELTKLDRDA RKRESRHLRD EAREKEALKE RSVKEREVPI SLEVSRGSRA EVSTIHLQSP GRKDVSHSGG REAETKETRF RLDTQDTASS LQSDSTTETI AESIVTTILK QFTQSPGAEE EATSFPDTKV TYVDRKEFPG DGKTKTEIVV ESKLTDVVDV SDEAGLDYLL SKDVKEVGLK GKSTETMIGE MINLGLKGRE GRAKVVNVEI VEEPMSYIGG GKIDFSTPFQ VEEVDDVSPS PKGFVEEEDG EGETHMAFSM RPHQTKQPQG TIPHVEEVTE AGDSEGEQSY FVSTPDEYPG GHDREDDGSV YGQIHIEEES TIRYSWQDEI AQGTWRRKMR GDVGGEKPVK VLEVPALSLG GAIGSAHLKE EASGELRAEP TVIEKEIKIP HEFHTSIKGV FSSEPRHQLV EVIGQLEETL PERMKEELSA LTRQSQGESG SVSVDVKKVQ SAAGGSVTLM AEVNLSQTVD ADQLDLEQLS RDEAGEIERA VESVVRESLA KRSSPVPRSP DREDGEEVPA GGILFKRWAT RELYSPSGER DDAGQVSPSS DQRVTQGPVS ATVEVTSPTG FVQSHVLEDV SQSVRHVKLG PTEMWRTEQV TFGGPTAQVV EVSGDFSEAV SSEGASRSVR HITLGPHQSQ VSTEVIFRGS VPTWQETGDT EKPGPVVLSV GADISGSGRM PGSERSHTEK EIRFQGPVSG TAQVGGNFAT EESVGSQTFV RSLQLGPKEG FREEIQFIAP IPDKVGWGEE DSEHTKVSLE RATSIQRIDI VPQRYLASKQ MAPQTLEFRD SEDMVMVEGS AGTIQATHNF TSDREILQNK ENTFQRVISG SPPDSVGDTG AEVTANVSRS FRHIQIGPTE EEPSEYFVTG RPVSKTFVLD GSVASPGLVG GADGGSTPCR IALGPKETSF TFQMDLSDTR AIRSWTRDTG SEVEAHGVSH RGGWRIAHSR DERVASTGSG ASPGDAHQAP GEKGTEQAGF DKTVQLQRMV DQRSVASDEK KVALLYLDNE EEEEEEGEGW F Sequence without tag. The proposed Purification-Tag is based on experiences with the expression system, a different complexity of the protein could make another tag necessary. In case you have a special request, please contact us.

Specificity: If you are looking for a specific domain and are interested in a partial protein or a different isoform, please contact us regarding an individual offer.

Characteristics: Key Benefits:

• Made to order protein - from design to production - by highly experienced protein experts.
• Protein expressed in mammalian cells and purified in one-step affinity chromatography
• The optimized expression system ensures reliability for intracellular, secreted and transmembrane proteins.
• State-of-the-art algorithm used for plasmid design (Gene synthesis).

This protein is a made-to-order protein and will be made for the first time for your order. Our experts in the lab try to ensure that you receive soluble protein.

If you are not interested in a full length protein, please contact us for individual protein fragments.

The big advantage of ordering our made-to-order proteins in comparison to ordering custom made proteins from other companies is that there is no financial obligation in case the protein cannot be expressed or purified.

Purity: > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)

Grade: custom-made

Application Details

Application Notes: We expect the protein to work for functional studies. As the protein has not been tested for functional studies yet we cannot offer a guarantee though.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: The buffer composition is at the discretion of the manufacturer.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -80 °C

Storage Comment: Store at -80°C.

Expiry Date: 12 months

Target Details

Target: SYNM (Synemin, Intermediate Filament Protein (SYNM))

Alternative Name: Synm (SYNM Products)

Background: Synemin (Desmuslin),FUNCTION: Type-VI intermediate filament (IF) which plays an important cytoskeletal role within the muscle cell cytoskeleton. It forms heteromeric IFs with desmin and/or vimentin, and via its interaction with cytoskeletal proteins alpha-dystrobrevin, dystrophin, talin-1, utrophin and vinculin, is able to link these heteromeric IFs to adherens-type junctions, such as to the costameres, neuromuscular junctions, and myotendinous junctions within striated muscle cells (By similarity). {ECO:0000250, ECO:0000269|PubMed:15265691}.

Molecular Weight: 173.2 kDa

UniProt: Q70IV5

AlphaFold: Q70IV5