MTBP Protein (AA 1-894) (His tag)
custom-made
MTBP
Origin: Mouse
Host: HEK-293 Cells
Recombinant
> 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
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- Target See all MTBP products
- MTBP (MDM2 Binding Protein (MTBP))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 1-894
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Origin
- Mouse
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This MTBP protein is labelled with His tag.
- Purpose
- Made-to-order recombinant Mtbp Protein expressed in mammalian cells.
- Sequence
- MDRYLLLVTW REGKFRSVAG GEIEPGTEAT SLESTDKQPD LTATNIYHLL KRSISDSIHP DDSTFPACSV GGTPHSRKWF FAVQAICGFY QFCSSDWQEI HFDAEKDKIE DVLQANIEEC QSAVECFEED DSNSRESLPL ADLYEESAEN LHQLSDKLPA PGRAMIDIIL LPSDKDPPKL KECLPIVGAL KHLKEWHSAK VIIAGSYCEI NCQKIAEYLS ASVVPLEEFR NAIDPRELWR GEIQMRERKF GFEISFPEFC LKGVTPTNVS AYNLNTCFLA KKIASSKVFH YYGPALEFVQ MIKLSDLPSC YMSDIEFELE VTGHCTRQNS MLLLEQISSL CGKVGALFVL PCTVSNVLIP PPSQLASRKW KEYMAKKPKT ISVPDVAVKG EFSGYHLLLQ GMGKRKCRAT LLHSASQING SFALSVIHGK MKTKAGEARP SFPFDFSSLP RFSEEQVLQR EKQLASFQVL ALKECLKRRK AANQPEAFSA DELKSLLALT RERFLGHFDV LPTEAALAQT DTVKAAGVVN DDGTVEPYSS SLMETNPLEW PERHVLQNLE TSEKAKQKMR TGSLPRSSEQ LLGHKEGPRD SLTLLDAKEL LKYFTSDGLP VGDLQPLHIQ RGEKPFVLTP ELSPGKLQVL PFEKASECHY HGIEYCLDDQ KALERDGGFS ELQSRLIRYE TQTTCTRDSF PVPTVLSPLP SPAVLSEPQS VPEGEALQGE LRTEVSGLKR RSKDPSCLYP QKRLTRSESS DCLPSQASCN SNHHHHTGKP RKPQAERCVS GLPLPGREAS KDTSKTSSGQ KRAHESKSSK QMKESRSQKH TRMLKEVVKD TLKRHHITEA HESFTACSQR LFDISKFYLK DLKTSRGLFE EMKKTANNNV VQVIEWVVEK MSKK Sequence without tag. The proposed Purification-Tag is based on experiences with the expression system, a different complexity of the protein could make another tag necessary. In case you have a special request, please contact us.
- Specificity
- If you are looking for a specific domain and are interested in a partial protein or a different isoform, please contact us regarding an individual offer.
- Characteristics
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Key Benefits:
- Made to order protein - from design to production - by highly experienced protein experts.
- Protein expressed in mammalian cells and purified in one-step affinity chromatography
- The optimized expression system ensures reliability for intracellular, secreted and transmembrane proteins.
- State-of-the-art algorithm used for plasmid design (Gene synthesis).
If you are not interested in a full length protein, please contact us for individual protein fragments.
The big advantage of ordering our made-to-order proteins in comparison to ordering custom made proteins from other companies is that there is no financial obligation in case the protein cannot be expressed or purified. - Purity
- > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
- Grade
- custom-made
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MDM2 Binding Protein (MTBP) (AA 1-904) protein (His tag)
custom-made MTBP Origin: Human Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
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- Application Notes
- We expect the protein to work for functional studies. As the protein has not been tested for functional studies yet we cannot offer a guarantee though.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- The buffer composition is at the discretion of the manufacturer.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -80 °C
- Storage Comment
- Store at -80°C.
- Expiry Date
- 12 months
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- Target
- MTBP (MDM2 Binding Protein (MTBP))
- Alternative Name
- Mtbp (MTBP Products)
- Background
- Mdm2-binding protein ( mMTBP),FUNCTION: May play a role in MDM2-dependent p53/TP53 homeostasis in unstressed cells. Inhibits autoubiquitination of MDM2, thereby enhancing MDM2 stability. This promotes MDM2-mediated ubiquitination of p53/TP53 and its subsequent degradation. Inhibits cell migration in vitro and suppresses the invasive behavior of tumor cells. {ECO:0000269|PubMed:10906133, ECO:0000269|PubMed:15632057}.
- Molecular Weight
- 100.3 kDa
- UniProt
- Q8BJS8
- AlphaFold
- Q8BJS8
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