CD137 Protein
Quick Overview for CD137 Protein (ABIN935241)
Target
See all CD137 (TNFRSF9) ProteinsProtein Type
Biological Activity
Origin
Source
Purity
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Sequence
- MERTRSLQDP CSNCPAGTFC DNNRNQICSP CPPNSFSSAG GQRTCDICRQ CKGVFRTRKE CSSTSNAECD CTPGFHCLGA GCSMCEQDCK QGQELTKKGC KNCCFGTFND QKRGICRPWT NCSLDGKSVL VNGTKERDVV CGPSPADLSP GASSVTPPAP AREPGHS
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Characteristics
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Purified recombinant Human CD137 protein
Expression System: E.coli
Bioactivity: Determined by its inhibitory effect of the 4-1BBL mediated stimulation of IL-8 production by human PBMC. About 90 % of inibition was seen using a concentration of 1ug for both 4-1BBL and 4-1BBR. -
Endotoxin Level
- < 0.1 ng per µg (1 EU/µg).
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Tumor Necrosis Factor Receptor Superfamily, Member 9 (TNFRSF9) (AA 24-186) protein (Fc-Avi Tag)
TNFRSF9 Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Tumor Necrosis Factor Receptor Superfamily, Member 9 (TNFRSF9) (AA 24-186) protein (His tag)TNFRSF9 Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Tumor Necrosis Factor Receptor Superfamily, Member 9 (TNFRSF9) (AA 24-186) protein (His-Avi Tag,Biotin)TNFRSF9 Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Tumor Necrosis Factor Receptor Superfamily, Member 9 (TNFRSF9) (AA 24-186) protein (His tag)TNFRSF9 Origin: Cynomolgus, Rhesus Monkey Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Tumor Necrosis Factor Receptor Superfamily, Member 9 (TNFRSF9) (AA 24-186) protein (Fc-Avi Tag,Biotin)TNFRSF9 Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Tumor Necrosis Factor Receptor Superfamily, Member 9 (TNFRSF9) (AA 24-186) protein (mFc-His Tag)TNFRSF9 Origin: Human Host: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining. ELISA, FACS
Tumor Necrosis Factor Receptor Superfamily, Member 9 (TNFRSF9) (AA 24-211) protein (His tag)TNFRSF9 Origin: Mouse Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Tumor Necrosis Factor Receptor Superfamily, Member 9 (TNFRSF9) (AA 46-128) protein (His-DYKDDDDK-Strep II Tag)TNFRSF9 Origin: Human Host: HEK-293T Cells Recombinant SDS, WB, ELISA, PI
Tumor Necrosis Factor Receptor Superfamily, Member 9 (TNFRSF9) (AA 24-186) protein (His-DYKDDDDK-Strep II Tag)TNFRSF9 Origin: Human Host: HEK-293T Cells Recombinant SDS, WB, ELISA, PI
Tumor Necrosis Factor Receptor Superfamily, Member 9 (TNFRSF9) (AA 24-211) protein (Fc Tag)TNFRSF9 Origin: Mouse Host: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE.
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Buffer
- Supplied as a lyophilized powder.
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Handling Advice
- Avoid repeated freeze/thaw cycles.
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Storage
- 4 °C/-20 °C
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Storage Comment
- Store at 4 °C until reconstitution. Following reconstitution aliquot and freeze at -20 °C for long term storage.
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- CD137 (TNFRSF9) (Tumor Necrosis Factor Receptor Superfamily, Member 9 (TNFRSF9))
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Alternative Name
- CD137
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Background
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CD137 or 4-1BB Receptor, a member of the TNF superfamily of receptors, is mainly expressed on the surface of a variety of T cells, but also found in B cells, monocytes, and various transformed cell lines. 4-1BB Receptor binds to 4-1BBL to provide a co-stimulatory signal for T lymphocytes. Signaling by 4-1BB Receptor has been implicated in the antigen-presentation process and generation of cytotoxic T cells. The human 4-1BB Receptor gene codes for a 255 amino acid type I transmembrane protein containing a 17 amino acid N-terminal signal sequence, a 169 amino acid extracellular domain, a 27 amino acid transmembrane domain and a 42 amino acid cytoplasmic domain.
Alternative Names: CD137 protein, CD-137, 4-1BB Receptor protein, TNFRSF9 protein, CD-137 protein, T-cell antigen ILA protein, CD 137, CD137, CD 137 protein -
Molecular Weight
- 17.7 kDa
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Pathways
- Cancer Immune Checkpoints
Target
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