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Ccr7 functions during axis formation as a GPCR to inhibit beta-catenin (show CTNNB1 Proteins), likely by promoting Ca(2 (show CA2 Proteins)+) transients throughout the blastula.
Prominent mucosal immune responses in CCR7-deficient mice increased the efficiency of bacteria clearance from the FRT(female reproductive tract) while reducing tissue-associated inflammation and pathology; increased numbers of lymphocytes within the FRT result in pathogen clearance with reduced immune-mediated pathology
CCR7 is required to mount a robust immune response against enteropathogenic Y. pseudotuberculosis by promoting Th17-like responses in mesenteric lymph nodes.
CCR7 overexpression and RelB (show RELB Proteins) knockdown (KD) in imDCs improve skin-graft survival in a murine skin-transplantation model. Transfection with Ad-CCR7 and RelB (show RELB Proteins) KD in imDCs may be an effective approach inducing immune tolerance, thus being potentially valuable for inhibiting allograft rejection.
data point to Ccr7 as a critical host defense restriction factor limiting neuroinflammation during acute West Nile virus infection
The results suggest that CCR7 plays a causal role in maintaining innate and adaptive immunity in obesity.
these data indicate that CCR7 and BTLA (show BTLA Proteins) cooverexpression imparts an intermediate immune phenotype in mmature dendritic cells when compared to that in CCR7- or BTLA (show BTLA Proteins)-expressing counterparts that show a more immunocompetent or immunotolerant phenotype
Results suggest that baicalin exerts an inhibitory effect on airway inflammation, and this effect may be associated with the inhibition of CCR7 and its ligands, CCL19 (show CCL19 Proteins) and CCL21 (show CCL21 Proteins), as well as on the nuclear factor-Kappa B (NF-kappaB (show NFKB1 Proteins)) pathway in a mouse model of asthma.
This study reveals a role for CCR7 in limiting Treg recirculation back to the thymus and enables separation of the mechanisms controlling Treg production and thymic recirculation.
data reveal that CCR7 plays multifaceted roles in regulating collecting vessel permeability and fibrosis, with one of the key players being IRF4 (show IRF4 Proteins)-dependent DCs.
the graft site microenvironment plays a critical role in alloimmunity by determining DC trafficking through the CCR7-CCL19 (show CCL19 Proteins)/21 axis.
The analysis of gene amplification and mRNA levels showed the expression of CCR7 in breast cancer correlated with better prognosis.
that CCR7 mediates TGF-beta1 (show TGFB1 Proteins)-induced MMP2 (show MMP2 Proteins)/9 expression through NF-kappaB (show NFKB1 Proteins) signaling
leukocyte subsets express distinct patterns of CCR7 sialylation that contribute to receptor signaling and fine-tuning chemotactic responses.
tumor microenvironment stimulation down-regulated the migration of CCR7-expressing tumor cells toward CCL21 (show CCL21 Proteins) and inhibited the formation of directional protrusions toward CCL21 (show CCL21 Proteins) in a novel 3-dimensional hydrogel system.
CCR7 expression levels in human tumors correlate with signatures of CD141 (show THBD Proteins)(+) DC, intratumoral T cells, and better clinical outcomes.
specific role for CCL21/CCR7 in promoting EMT and metastasis in CD133+ pancreatic cancer stem-like cells
This study showed that CCR7 are overexpressed in CD4 (show CD4 Proteins)(-) CD8 (show CD8A Proteins)(-) thymocytes of myasthenia gravis patients.
High tumoral CCR7 expression correlated with potential lymphatic involvement and poor prognosis of metastatic renal cell carcinoma (show MOK Proteins) patients treated with tyrosine kinase (show TXK Proteins) inhibitors.
Results show that upregulation of CCR7 promotes cell proliferation and inflammation in A549 non-small cell lung cancer cells. However, silencing of CCR7 via siRNA treatment promotes cell apoptosis and suppresses the inflammatory response and TGF-beta1 (show TGFB1 Proteins)-induced EMT (show ITK Proteins), which may be associated with NF-kappaB (show NFKB1 Proteins) signaling.
Down-regulating CCR7 expression in MG63 cells could apparently inhibit cell proliferation, migration and invasion abilities of MG63 cells, and also induce cell apoptosis.
Fluorescent dye-labeled gammadelta T cells from afferent and efferent lymph lack CCR7 surface expression and display high levels of CD62L (show SELL Proteins) compared with CD4 (show CD4 Proteins) T cells, which do express CCR7.
CCR7 transcripts were minimally expressed in ex vivo and proliferating WC1(+)gammadelta T cells, a unique cell population with proinflammatory characteristics
the pattern of expression of CCR7 in different populations of porcine lymphocytes appears to be similar to that of human, highlighting the value of the pig as a useful animal model for biomedical studies.
Pre-translntation of sertli cell CCR7 significantly suppresses lymphocyte proliferation and prolongs allogeneic skin graft survival.
The protein encoded by this gene is a member of the G protein-coupled receptor family. This receptor was identified as a gene induced by the Epstein-Barr virus (EBV), and is thought to be a mediator of EBV effects on B lymphocytes. This receptor is expressed in various lymphoid tissues and activates B and T lymphocytes. It has been shown to control the migration of memory T cells to inflamed tissues, as well as stimulate dendritic cell maturation. The chemokine (C-C motif) ligand 19 (CCL19/ECL) has been reported to be a specific ligand of this receptor.
C-C chemokine receptor type 7
, CC chemokine receptor 7
, chemokine (C-C motif) receptor 7 a
, chemokine (C-C motif) receptor 7
, c-C chemokine receptor type 7-like
, C-C CKR-7
, EBV-induced G-protein coupled receptor 1
, MIP-3 beta receptor
, chemokine (C-C) receptor 7
, epstein-Barr virus-induced G-protein coupled receptor 1
, EBV-induced G protein-coupled receptor 1
, Epstein-Barr virus induced G-protein coupled receptor
, Epstein-Barr virus induced gene 1
, lymphocyte-specific G protein-coupled peptide receptor
, chemokine receptor 7