Junction Mediating and Regulatory Protein, P53 Cofactor Proteins

Protein Summary

Acts both as a nuclear p53/TP53-cofactor and a cytoplasmic regulator of actin dynamics depending on conditions. In nucleus, acts as a cofactor that increases p53/TP53 response. Increases p53/TP53-dependent transcription and apoptosis, suggesting an important role in p53/TP53 stress response such as DNA damage. In cytoplasm, acts as a nucleation-promoting factor for both branched and unbranched actin filaments. Activates the Arp2/3 complex to induce branched actin filament networks. Also catalyzes actin polymerization in the absence of Arp2/3, creating unbranched filaments. Contributes to cell motility by controlling actin dynamics.

Alternative names and synonyms associated with Junction Mediating and Regulatory Protein, P53 Cofactor (JMY)

• junction mediating and regulatory protein, p53 cofactor (JMY) antibody
• junction mediating and regulatory protein, p53 cofactor (jmy) antibody
• junction-mediating and regulatory protein (Jmy) antibody

• WHDC1L3 antibody

Protein level used designations for JMY

junction mediating and regulatory protein, p53 cofactor , junction-mediating and regulatory protein , junction-mediating and -regulatory protein , WAS protein homology region 2 domain containing 1-like 3 , p300 transcriptional cofactor JMY