The protein encoded by this gene acts as a guanine nucleotide exchange factor for the RHO family of small GTP-binding proteins (RACs). It has been shown to bind to and activate RAC1 by exchanging bound GDP for free GTP. The encoded protein, which is found mainly in the cytoplasm, is activated by phosphatidylinositol-3,4,5-trisphosphate and the beta-gamma subunits of heterotrimeric G proteins.
Alternative names and synonyms associated with PREX1
phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1 L homeolog (prex1.L) ELISA Kit