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This study reveals a function for the imprinted gene Grb10 in regulating hematopoietic stem cell self-renewal.
In tumors, Grb10 loss independently promotes Ras pathway hyperactivation, which promotes hyperproliferation, an early feature of tumor development.
This study identified Grb10 as a critical regulator of lipid metabolism, the programming of the browning phenotype, and thermogenesis in adipose tissues.
Negative regulation of Grb10 Interacting GIGYF2 (show GIGYF2 Proteins) protein on IGF-1 (show IGF1 Proteins) receptor signaling pathway caused diabetic mice cognitive impairment.
Grb10 is involved in BCR-ABL (show ABL1 Proteins)-positive leukemia in mice.
Grb10 is a key genetic component of developmental programming.
Glucose uptake was higher in Grb10(-/-) primary myotubes in the basal state and was associated with enhanced insulin (show INS Proteins) signaling and an increase in GLUT4 (show SLC2A4 Proteins) translocation to the plasma membrane.
Grb10 expression in mouse embryo is regulated by Lmx1a (show LMX1A Proteins) transcription factor.
Results suggest consecutive passaging may affect epigenetic modifications of Grb10 in adult fibroblast cells.
Study has identified Grb10 as an important regulator of beta-cell proliferation and demonstrated that reducing the expression level of Grb10 could provide a novel means to increase beta-cell mass and reduce beta-cell apoptosis.
Study found FGFR3 (show FGFR3 Proteins) gene mutation plus GRB10 gene duplication in a patient with achondroplasia plus growth delay with prenatal onset
Data suggest that GRB10 and GRB14 (show GRB14 Proteins) are both Ca2 (show CA2 Proteins)+-dependent CaM-binding proteins; more than one CaM-binding site and/or accessory CaM-binding sites appear to exist in GRB10 and GRB14 (show GRB14 Proteins), as compared to a single one present in GRB7 (show GRB7 Proteins). (GRB10 = growth factor receptor-bound protein 10; GRB14 (show GRB14 Proteins) = growth factor receptor-bound protein 14 (show GRB14 Proteins); CaM = calmodulin; GRB7 (show GRB7 Proteins) = growth factor receptor-bound protein 7 (show GRB7 Proteins))
GRB10 may regulate degradation of the IL-4 (show IL4 Proteins) receptor-signaling complex through interactions with NEDD4.2 (show NEDD4L Proteins).
Risk alleles for 6 loci increased glucose levels from birth to 5 years of age (ADCY5 (show ADCY5 Proteins), ADRA2A (show ADRA2A Proteins), CDKAL1 (show CDKAL1 Proteins), CDKN2A/B, GRB10, and TCF7L2 (show TCF7L2 Proteins)
This study demonstrated that the most significant SNP (rs11770199; p = 0.0003) in single-site analysis was located on chromosome 7 in the GRB10 gene.
Association of the intronic polymorphism rs12540874 A>G of the GRB10 gene with high birth weight.
Tissue-specific methylation and possibly imprinting of GRB10 can influence glucose metabolism.
Grb10 binds to both normal and oncogenic FLT3 (show FLT3 Proteins) and induces PI3K (show PIK3CA Proteins)-Akt (show AKT1 Proteins) and STAT5 (show STAT5A Proteins) signaling pathways resulting in an enhanced proliferation, survival and colony formation of hematopoietic cells.
Studies indicate that insulin receptor (IR (show INSR Proteins)) and IGF Type 1 Receptor (IGFR) have been identified as important partners of Grb10/14 and SH2B1 (show SH2B1 Proteins)/B2 adaptors.
H19 (show NCKAP1 Proteins) and GRB10 methylation was normal in Albright's hereditary osteodystrophy patients.
The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors. Overexpression of some isoforms of the encoded protein inhibits tyrosine kinase activity and results in growth suppression. This gene is imprinted in a highly isoform- and tissue-specific manner, with expression observed from the paternal allele in the brain, and from the maternal allele in the placental trophoblasts. Alternatively spliced transcript variants encoding different isoforms have been identified.
growth factor receptor-bound protein 10
, zgc:91987growth factor receptor-bound protein 10
, growth factor receptor-bound protein 10-like
, GRB10 adapter protein
, maternally expressed gene 1 protein
, GRB10 adaptor protein
, insulin receptor-binding protein Grb-IR
, maternally expressed gene 1
, adapter protein
, binds to insulin receptor and IGF1R