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anti-Human HRH1 Antibodies:
anti-Mouse (Murine) HRH1 Antibodies:
anti-Rat (Rattus) HRH1 Antibodies:
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Human Polyclonal HRH1 Primary Antibody for IHC (p) - ABIN4317552
Dagli, Goksu, Eryilmaz, Mocan Kuzey, Bayazit, Gun, Gocer: Expression of histamine receptors (H(1), H(2), and H(3)) in the rabbit endolymphatic sac: an immunohistochemical study. in American journal of otolaryngology 2007
Human Polyclonal HRH1 Primary Antibody for IHC (p), IHC - ABIN269800
Kawakami, Miyoshi, Horio, Fukui: Beta(2)-adrenergic receptor-mediated histamine H(1) receptor down-regulation: another possible advantage of beta(2) agonists in asthmatic therapy. in Journal of pharmacological sciences 2004
Human Polyclonal HRH1 Primary Antibody for ELISA, IHC - ABIN449538
Bryce, Mathias, Harrison, Watanabe, Geha, Oettgen: The H1 histamine receptor regulates allergic lung responses. in The Journal of clinical investigation 2006
Human Polyclonal HRH1 Primary Antibody for IF (p), IHC (p) - ABIN719606
Møller, Kirkeby, Vikeså, Nielsen, Caye-Thomasen: Expression of histamine receptors in the human endolymphatic sac: the molecular rationale for betahistine use in Menieres disease. in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery 2015
Human H1 receptors in Chinese hamster ovary cells are apparently down-regulated by a sustained increase in intracellular Ca(2 (show CA2 Antibodies)+) concentrations with no process of endocytosis and lysosomal/proteasomal degradation of receptors.
Antihistamines displayed similar kinetic signatures on antagonizing histamine-induced beta-arrestin2 (show ARRB2 Antibodies) recruitment as compared to displacing radioligand binding from the H1R.
Study suggests that both MAPK (show MAPK1 Antibodies) p44/p42 (show PSMC6 Antibodies) and PKC (show PRRT2 Antibodies) pathways appear to be involved in histamine-upregulated matrix metalloproteinase-9 (show MMP9 Antibodies) release via histamine H1 receptors in astrocytes.
that histamine H1 receptor activation mediates MAPK activation through PLCbeta, Src, PKCdelta and MEK pathway, but does not lead to nuclear relocalization of phospho-ERK (pERK), classically associated with pro-proliferative changes.
Activation of the H1R by its full agonists resulted in a composite potentiating effect. Intriguingly, inactivation of the Gaq (show GNAQ Antibodies)-PLC (show HSPG2 Antibodies) pathway by H1R inverse agonists resulted also in a potentiation of GR activity.
HRH1 (show DHX8 Antibodies)-mediated sensitization of TRPV1 (show TRPV1 Antibodies) is involved in IBS. Ebastine, an antagonist of HRH1 (show DHX8 Antibodies), reduced visceral hypersensitivity, symptoms, and abdominal pain in patients with IBS.
HRH1 (show DHX8 Antibodies)-17 TT and HNMT (show HNMT Antibodies)-1639 TT genotypes were associated with the allergic asthma phenotype among African-American children and that the ABP (show ABP1 Antibodies) 4107 GG genotype was associated with nonallergic asthma among white children.
HRH1 (show DHX8 Antibodies) transcript was significantly down-modulated in multiple sclerose compared with health control.
The relationship between the expression of HRH1 (show DHX8 Antibodies) and prognosis was found to vary in different types of cancers, even in the same cancer from different databases.
But carriers of one or three copies of HRH1 (show DHX8 Antibodies) (5% of individuals), HRH2 (show DHX15 Antibodies) (1.1%) and HRH4 (show HRH4 Antibodies) genes (0.9%) were also identified.
Sympathetic tone changed in H1R-, but not H2R (show HRH2 Antibodies)- or H3R (show HRH3 Antibodies)-null mice.
The results of this study suggest that H1R deficiency in mice is associated with pronounced deficits in hippocampus-dependent spatial learning and memory.
histamine receptor H1 and histamine receptor H2 (show HRH2 Antibodies) reciprocally regulate inflammation in the ligation-induced arteriosclerosis
Histamine demonstrably inhibited ACh (show FGFR3 Antibodies)-induced sweating in both mice and humans via H1R-mediated signaling.
This study provides a potential mechanism of H1R-mediated signaling and NF-kB pathway crosstalk in allergic inflammationptor
Neuronal damage is significantly increased in H1R knock-out mice following status epilepticus.
Histamine H1 Receptor expression by CD11B (show ITGAM Antibodies)(+) cells is not required for susceptibility to experimental allergic encephalomyelitis.
histamine signaling through the H1R on dendritic cells is an important early event conditioning the quality of the skin effector immune response.
endothelial H(1)R expression reduces BBB (show ALMS1 Antibodies) permeability, suggesting that endothelial H(1)R signaling may be important in the maintenance of cerebrovascular integrity
Regulation of sleep/wake states is completely achieved by OX(2)R (show HCRTR2 Antibodies)-expressing neurones without involving H(1)R-mediated pathways. Maintenance of basal physiological sleep/wake states is fully achieved without both H(1) and OX(1 (show NQO1 Antibodies)) receptors.
caveolar and cholesterol integrity are indispensable for the proper functionality of the H(1) and 5-HT(2A) receptors through their Rho/ROCK signaling.
Histamine H1 receptor mRNA is detected in horizontal cell perikarya and primary dendrites of retina.
The histaminergic system regulates wakefulness and orexin/hypocretin (show OX Antibodies) neuron development via histamine receptor H1.
Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. This gene was thought to be intronless until recently. The protein encoded by this gene is an integral membrane protein and belongs to the G protein-coupled receptor superfamily. It mediates the contraction of smooth muscles, the increase in capillary permeability due to contraction of terminal venules, the release of catecholamine from adrenal medulla, and neurotransmission in the central nervous system. Multiple alternatively spliced variants, encoding the same protein, have been identified.
, histamine H(1) receptor
, histamine H1 receptor
, histamine receptor, subclass H1
, Bordetella pertussis induced histamine sensitization
, histamine receptor subtype H1
, histamine receptor H1
, 7 transmembrane receptor