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anti-Human HRH1 Antibodies:
anti-Mouse (Murine) HRH1 Antibodies:
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Human Polyclonal HRH1 Primary Antibody for ELISA, IHC - ABIN449538
Bryce, Mathias, Harrison, Watanabe, Geha, Oettgen: The H1 histamine receptor regulates allergic lung responses. in The Journal of clinical investigation 2006
Human Polyclonal HRH1 Primary Antibody for IHC (p), IHC - ABIN269800
Kawakami, Miyoshi, Horio, Fukui: Beta(2)-adrenergic receptor-mediated histamine H(1) receptor down-regulation: another possible advantage of beta(2) agonists in asthmatic therapy. in Journal of pharmacological sciences 2004
Human Polyclonal HRH1 Primary Antibody for IF (p), IHC (p) - ABIN719606
Møller, Kirkeby, Vikeså, Nielsen, Caye-Thomasen: Expression of histamine receptors in the human endolymphatic sac: the molecular rationale for betahistine use in Menieres disease. in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery 2015
Human Polyclonal HRH1 Primary Antibody for IHC (p) - ABIN4317552
Dagli, Goksu, Eryilmaz, Mocan Kuzey, Bayazit, Gun, Gocer: Expression of histamine receptors (H(1), H(2), and H(3)) in the rabbit endolymphatic sac: an immunohistochemical study. in American journal of otolaryngology 2007
Study identified HRH1 as a receptor frequently overexpressed in basal and HER2-targeted therapy-resistant breast cancer (BC) cells, demonstrating that HRH1 inhibition culminates in apoptotic death and hampers tumor growth. ERK activation was identified as the mechanism through which HRH1 blockade signals to promote death in basal BC cells.
H1R and H4R are useful biomarkers of allergic inflammation on the ocular surface. Most notably, H4R expressed on eosinophils is useful as a biomarker of eosinophilic inflammation of the ocular surface.
This study demonstrated that HRH1 gene polymorphisms associated with sedation in clozapine-treated patient with schizophrenia.
Human H1 receptors in Chinese hamster ovary cells are apparently down-regulated by a sustained increase in intracellular Ca(2+) concentrations with no process of endocytosis and lysosomal/proteasomal degradation of receptors.
Antihistamines displayed similar kinetic signatures on antagonizing histamine-induced beta-arrestin2 recruitment as compared to displacing radioligand binding from the H1R.
Study suggests that both MAPK p44/p42 and PKC pathways appear to be involved in histamine-upregulated matrix metalloproteinase-9 release via histamine H1 receptors in astrocytes.
that histamine H1 receptor activation mediates MAPK activation through PLCbeta, Src, PKCdelta and MEK pathway, but does not lead to nuclear relocalization of phospho-ERK (pERK), classically associated with pro-proliferative changes.
Activation of the H1R by its full agonists resulted in a composite potentiating effect. Intriguingly, inactivation of the Gaq-PLC pathway by H1R inverse agonists resulted also in a potentiation of GR activity.
HRH1-mediated sensitization of TRPV1 is involved in IBS. Ebastine, an antagonist of HRH1, reduced visceral hypersensitivity, symptoms, and abdominal pain in patients with IBS.
HRH1-17 TT and HNMT-1639 TT genotypes were associated with the allergic asthma phenotype among African-American children and that the ABP 4107 GG genotype was associated with nonallergic asthma among white children.
multiple signaling pathways contribute to histamine-induced endothelial barrier dysfunction via the H1 receptor.
Thus, the results in the initial study were due to the degradation of histamine in skeletal muscle by ascorbate, because the histaminergic vasodilatation was unaffected by N-acetylcysteine.
HRH1 transcript was significantly down-modulated in multiple sclerose compared with health control.
The relationship between the expression of HRH1 and prognosis was found to vary in different types of cancers, even in the same cancer from different databases.
But carriers of one or three copies of HRH1 (5% of individuals), HRH2 (1.1%) and HRH4 genes (0.9%) were also identified.
Overexpression of H1R further increases the oxidative output of Duox-expressing HEK-293 cells.
Histamine demonstrably inhibited ACh-induced sweating in both mice and humans via H1R-mediated signaling.
our study does not support the contribution of histamine H1HR gene variants to antipsychotic induced weight gain nor differences in distribution between healthy volunteers and patients with schizophrenia
In this review, we focus on the role of histamine and its receptors in the treatment of Alzheimer's disease.
Our observations point to a close histamine-/HR-mediated activation of dermal macrophages, leading to modified cell differentiation and responsiveness via H1R, which might contribute to the aggravation of allergic skin inflammation in AD.
effects of histamine H1 type receptor (H1R) in regulating osteoblastic cell differentiation and mineralization
Data (including data from studies in knockout mice) suggest that sleep-promoting effect of dietary supplement rice bran is dependent on Hrh1 antagonism; rice bran fully inhibits Hrh1 agonist-induced increase in action potential frequency in tuberomammillary nucleus neurons.
Study showed that the sleep-wake cycle in H1-/- mice was affected both quantitatively and qualitatively: long-term abolition of histamine impairs cortical EEG, affects sleep-wake qualities and causes sleepiness facing behavioral challenges
this study shows that the histamine 1 receptor might be useful therapeutic target for treatment of metal allergy
Sympathetic tone changed in H1R-, but not H2R- or H3R-null mice.
The results of this study suggest that H1R deficiency in mice is associated with pronounced deficits in hippocampus-dependent spatial learning and memory.
These results reveal a crucial role for H1- and H4-receptors for Th2 migration and cytokine secretion in a Th2-driven model of skin inflammation.
histamine receptor H1 and histamine receptor H2 reciprocally regulate inflammation in the ligation-induced arteriosclerosis
Histamine H1 receptors (but not H2) mediate emotional memory consolidation impairment.
Histamine H1 receptors in the amygdala are not involved in anxiety-like behavior but are involved in emotional memory.
This study provides a potential mechanism of H1R-mediated signaling and NF-kB pathway crosstalk in allergic inflammationptor
Neuronal damage is significantly increased in H1R knock-out mice following status epilepticus.
Histamine H1 Receptor expression by CD11B(+) cells is not required for susceptibility to experimental allergic encephalomyelitis.
An increase in regulatory T cells was observed, yet these cells were incapable of controlling myocarditis in H(1)R(-/-) mice. an increase in regulatory T cells was observed, yet these cells were incapable of controlling myocarditis in H(1)R(-/-) mice.
histamine signaling through the H1R on dendritic cells is an important early event conditioning the quality of the skin effector immune response.
These data suggest that histamine H1 and H2 receptor signaling may regulate glucose and lipid metabolism and development of hyperlipidemia-induced nonalcoholic steatohepatitis.
endothelial H(1)R expression reduces BBB permeability, suggesting that endothelial H(1)R signaling may be important in the maintenance of cerebrovascular integrity
The study suggest that H1 receptors play a pivotal role in the regulation of seizure intensity and duration as well as seizure-induced neuronal damage in the immature P9 mice.
Regulation of sleep/wake states is completely achieved by OX(2)R-expressing neurones without involving H(1)R-mediated pathways. Maintenance of basal physiological sleep/wake states is fully achieved without both H(1) and OX(1) receptors.
caveolar and cholesterol integrity are indispensable for the proper functionality of the H(1) and 5-HT(2A) receptors through their Rho/ROCK signaling.
Histamine H1 receptor mRNA is detected in horizontal cell perikarya and primary dendrites of retina.
The histaminergic system regulates wakefulness and orexin/hypocretin neuron development via histamine receptor H1.
Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. This gene was thought to be intronless until recently. The protein encoded by this gene is an integral membrane protein and belongs to the G protein-coupled receptor superfamily. It mediates the contraction of smooth muscles, the increase in capillary permeability due to contraction of terminal venules, the release of catecholamine from adrenal medulla, and neurotransmission in the central nervous system. Multiple alternatively spliced variants, encoding the same protein, have been identified.
, histamine H(1) receptor
, histamine H1 receptor
, histamine receptor, subclass H1
, Bordetella pertussis induced histamine sensitization
, histamine receptor subtype H1
, histamine receptor H1
, 7 transmembrane receptor