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Here is presented a novel O-GlcNAc transferase (OGT), EOGT (show C3orf64 Proteins), responsible for extracellular O-linked-N-acetylglucosamine acylation.
study found that the super sex combs (sxc)gene encodes O-linked N-acetylglucosamine transferase (Ogt); Polycomb (show CBX2 Proteins) repression appears to be a critical function of Sxc/Ogt in Drosophila and may be mediated by the glycosylation of Polyhomeotic
Developmental regulation of zOGT transcriptional variants generated by alternative splicing and characterization of their OGT activities of protein O-GlcNAcylation.
Overexpression of Ogt delayed epiboly and caused a severe disorganization of the microtubule and actin based cytoskeleton in the extra-embryonic yolk syncytial layer.
Hsp90 is involved in the regulation of OGT and O-GlcNAc modification and that Hsp90 inhibitors might be used to modulate O-GlcNAc modification and reverse its adverse effects in human diseases.
Findings indicate O-linked N-acetylglucosamine transferase (OGT) as a cellular factor involved in human papillomaviruses type 16/18 E6 and E7 expressions and cervical cancer tumorigenesis, suggesting that targeting OGT in cervical cancer may have potential therapeutic benefit.
The findings suggest that OGT promotes the O-GlcNAc modification of HDAC1 (show HDAC1 Proteins) in the development of progression hepatocellular carcinoma.
Tax (show CNTN2 Proteins) interacts with the host OGT/OGA (show MGEA5 Proteins) complex and inhibits the activity of OGT-bound OGA (show MGEA5 Proteins).
We identified two human PRC2 complexes and two PR-DUB deubiquitination complexes, which contain the O-linked N-acetylglucosamine transferase OGT1 and several transcription factors.
Mutations in N-acetylglucosamine (O-GlcNAc) transferase in patients with X-linked intellectual disability
This work uncovers that URI-regulated OGT confers c-MYC (show MYC Proteins)-dependent survival functions in response to glucose fluctuations.
The results of this study showed that the OGT is essential for sensory neuron survival and target innervation.
The authors show that O-GlcNAcylation of KEAP1 (show KEAP1 Proteins) by OGT at serine 104 is required for the efficient ubiquitination and degradation of NRF2 (show GABPA Proteins).
Data suggest that O-GlcNAc transferase 1 (OGT1) specifically binds to, O-GlcNAcylates, and stabilizes nonspecific lethal protein3 (NSL3 (show KANSL3 Proteins)); stabilization of NSL3 (show KANSL3 Proteins) by OGT1 up-regulates global acetylation levels of histone 4 at Lys-5 (show AASDHPPT Proteins), Lys (show LYZ Proteins)-8, and Lys (show LYZ Proteins)-16.
conclusion, our results demonstrated that miR24 inhibits breast cancer cells invasion by targeting OGT and reducing FOXA1 (show FOXA1 Proteins) stability. These results also indicated that OGT might be a potential target for the diagnosis and therapy of breast cancer metastasis.
Data suggest that enzymes in hexosamine biosynthesis pathway and downstream protein O-GlcNAcylation are important for preimplantation development (show MTA2 Proteins); these include Ogt, Gfpt (glutamine (show GFPT1 Proteins)-fructose-6-P aminotransferase), and Oga (O-GlcNAcase (show MGEA5 Proteins)).
O-GlcNAc modification is essential for cold-induced thermogenesis and mitochondrial biogenesis in brown adipose tissue.
This study identifies OGT activity as an important regulator of SC functions such as myelin maintenance and axonal support.
cullin 3 (CUL3 (show CUL3 Proteins)), a cullin family E3 ubiquitin ligase (show MUL1 Proteins), down-regulates the expression of the O-GlcNAc transferase (OGT) and inhibits STAT3 (show STAT3 Proteins) O-GlcNAcylation.
OGT functions in metastatic spread of HPV E6/E7-positive tumor cells to the lungs through E6/E7, HCF-1 (show HCFC1 Proteins) and CXCR4 (show CXCR4 Proteins)
Furthermore, both Ogt and Oga (show MGEA5 Proteins) were required for the reversion from primed ESD (show ESD Proteins)-EpiSCs to naive rESCs. These findings indicate that O-GlcNAcylation plays an important role in the survival of primed ESD (show ESD Proteins)-EpiSCs and in their reversion to naive rESCs.
Beyond its well-known role in adding beta-O-GlcNAc to serine and threonine residues of nuclear and cytoplasmic proteins, OGT also acts as a protease in the maturation of the cell cycle regulator, HCF-1 (show HCFC1 Proteins), and serves as an integral member of several protein complexes, many of them linked to gene expression. (Review)
the O-linked N-acetylglucosamine (O-GlcNAc) processing enzymes, O-GlcNAc-transferase (OGT) and O-GlcNAcase (OGA (show MGEA5 Proteins)), interact with the (A)gamma-globin (show HBG1 Proteins) promoter at the -566 GATA repressor (show ZBTB32 Proteins) site
OGT overexpression increased the level of OGA (show MGEA5 Proteins), suggesting a compensatory mechanism for the aberrant O-GlcNAcylation.
O-GlcNAc transferase is at least partially required for maintaining cellular proliferative and migratory capacities of cardiomyocytes
This gene encodes a glycosyltransferase that catalyzes the addition of a single N-acetylglucosamine in O-glycosidic linkage to serine or threonine residues. Since both phosphorylation and glycosylation compete for similar serine or threonine residues, the two processes may compete for sites, or they may alter the substrate specificity of nearby sites by steric or electrostatic effects. The protein contains multiple tetratricopeptide repeats that are required for optimal recognition of substrates. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)
, O-linked GlcNAc transferase
, UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase
, O-linked N-acetylglucosamine transferase
, lethal (2) NC130
, O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase) 1
, copy I
, UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit
, o-linked GlcNAc transferase
, TPR repeat-containing protein
, UDP-N-acetylglucosamine:peptide N-acetylglucosaminyltransferase
, O linked N-acetylglucosamine transferase
, O-GlcNAc transferase subunit p110
, O-linked N-acetylglucosamine transferase 110 kDa subunit
, UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase
, O-GlcNAc transferase p110 subunit
, uridinediphospho-N-acetylglucosamine:polypeptide beta-N-acetylglucosaminyl transferase
, O linked N-acetylglucosamine transferase like