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Insulin resistance in obese boys leads to up-regulation of INSIG2 gene expression as well as to down-regulation of PFKFB1, PFKFB3, and HK2 genes in the blood cells as compared to obese patients with normal insulin sensitivity.
Results describe structural differences between two isozymes of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase from liver and testis.
Data show that cardiac overexpression of kinase-deficient PFK-2 reduces cardiac glycolysis that produced negative consequences to the heart including hypertrophy, fibrosis, and reduced cardiomyocyte function.
This gene encodes a member of the family of bifunctional 6-phosphofructo-2-kinase:fructose-2,6-biphosphatase enzymes. The enzyme forms a homodimer that catalyzes both the synthesis and degradation of fructose-2,6-biphosphate using independent catalytic domains. Fructose-2,6-biphosphate is an activator of the glycolysis pathway and an inhibitor of the gluconeogenesis pathway. Consequently, regulating fructose-2,6-biphosphate levels through the activity of this enzyme is thought to regulate glucose homeostasis. Multiple alternatively spliced transcript variants have been found for this gene.
, 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
, 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1-like
, 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1
, 6PF-2-K/Fru-2,6-P2ASE liver isozyme
, 6PF-2-K/Fru-2,6-P2ase 1
, PFK/FBPase 1
, 6PF-2-K/Fru-2,6-P2ase liver isozyme
, PFK-2/FBPase-2 gene A
, 6-phosphofructo-2 kinase /fructose-2,6-biphosphatase 1