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anti-Human PTH1R Antibodies:
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Cow (Bovine) Monoclonal PTH1R Primary Antibody for IHC (p), WB - ABIN444936
Madiraju, Gawri, Wang, Antoniou, Mwale: Mechanism of parathyroid hormone-mediated suppression of calcification markers in human intervertebral disc cells. in European cells & materials 2013
Show all 2 Pubmed References
Human Monoclonal PTH1R Primary Antibody for ICC, IHC - ABIN969372
Dean, Vilardaga, Potts, Gardella: Altered selectivity of parathyroid hormone (PTH) and PTH-related protein (PTHrP) for distinct conformations of the PTH/PTHrP receptor. in Molecular endocrinology (Baltimore, Md.) 2007
Show all 2 Pubmed References
Functional studies (IFA) showed a variation in expression between the WT and mutant PTH1R. In silico analysis showed structural differences between WT and mutant PTH1R proteins, particularly in the regions of the 3rd intracellular loop and the 6th transmembrane domain required for efficient PTH1R function.
Heterozygous mutations in the ATP4A (show ATP4A Antibodies) and PTH1R genes were identified in a family with type I gastric neuroendocrine tumors plus hypothyroidism and rheumatoid arthritis
It seems likely that Mut (show MUT Antibodies)-PTH1R may be, at least in part, co-localized with Wt-PTH1R by forming a heterodimer, leading to affect the function to each other in Jansen type metaphyseal chondrodysplasia (show COL11A1 Antibodies).
PTH1R mutation is associated with Primary Failure of Tooth Eruption.
Data suggest that GCGR (glucagon receptor (show GCGR Antibodies)) activation proceeds via a mechanism in which transmembrane helix 6 (TM6) is held in an inactive conformation by a conserved polar core and a hydrophobic lock (involving intracellular loop 3, IC3); mutations in the corresponding polar core of GCGR (show GCGR Antibodies) or PTH1R disrupt these inhibitory elements, allow TM6 to swing outward, and induce constitutive G protein signaling.
data highlight sequences in PTHR that contribute to NHERF1 (show SLC9A3R1 Antibodies) interaction and can be altered to prevent phosphorylation-mediated inhibition
Overt hypercalcemia is not always encountered in Jansen Metaphyseal Chondrodysplasia (show COL11A1 Antibodies) due to Heterozygous H223R-PTH1R Mutation.
data are consistent with the hypothesis that the pattern of C-terminal tail phosphorylation on PTH1R may determine the signaling outcome following receptor activation.
the data presented in this manuscript demonstrate a critical function of VPS35 (show vps35 Antibodies) in regulating PTH1R trafficking. This event and VPS35 (show vps35 Antibodies)-interaction with PPP1R14C (show PPP1R14C Antibodies) appear to be essential for turning off PTH1R's endosomal signaling, and promoting PTH1R-mediated catabolic response and bone remodeling.
PTH1R mutation causing primary failure of tooth eruption in a consanguineous Saudi family.
Knock-down of PTHR1 reveals its pro-malignant effects in osteosarcoma cells.
ZFPM2 (show ZFPM2 Antibodies), LEF1 (show LEF1 Antibodies), NR4A2 (show NR4A2 Antibodies), HAS2 (show HAS2 Antibodies), and RHOC (show RHOC Antibodies) might be potential targets of PTHR1 in osteosarcoma.
Pth1r in DMP1 (show DMP1 Antibodies)-8kb-expressing cells is required to maintain basal levels of bone resorption but is dispensable for the catabolic action of chronic PTH (show PTH Antibodies) elevation.
Results provide in vivo evidence of a role for RAMP2 (show RAMP2 Antibodies) in placental development distinct from the RAMP2 (show RAMP2 Antibodies)-calcitonin receptor-like receptor (show CALCRL Antibodies)/adrenomedullin (show ADM Antibodies) signaling paradigm; decreases Pthr1 expression and causes a blunted response to systemic parathyroid hormone (show PTH Antibodies); and identify additional pathways underlying the endocrine and fertility defects of the previously characterized Ramp2 (show RAMP2 Antibodies) heterozygous adult females.
Activation of PTHrP-cyclic AMP (show TMPRSS5 Antibodies)-CREB1 (show CREB1 Antibodies) signaling following p53 (show TP53 Antibodies) loss is essential for osteosarcoma initiation and maintenance.
A critical role for SNX27 (show SNX27 Antibodies)-retromer mediated transport of PTHR in normal bone development.
PTHrP and PTH (show PTH Antibodies) mediate wasting through a common mechanism involving PTHR.
we propose that PTH (show PTH Antibodies) has a direct effect on osteoblasts and osteoclasts, and that this effect is mediated through PTH1R, thus contributing to bone remodeling
Ihh (show IHH Antibodies) and PTH1R signaling in limb mesenchyme are both essential to regulate proper development of digit structures, although they appear to use different mechanisms.
cells expressing osterix (show SP7 Antibodies) are mesenchymal progenitors contributing to all relevant cell types during morphogenesis.
Loss of function of either PTHR1 or PTHrP in zebrafish leads to a localized aortic defect that is Notch (show NOTCH1 Antibodies) dependent.
The expression of the PTH/PTHrP receptor in dairy cows before and after parturition is reported.
This study reveals clear genetic-statistical evidence for a link of KRT8 (show KRT8 Antibodies), FAF1 (show FAF1 Antibodies) and PTH1R with some of leg weakness related traits in pigs.
These findings reveal that direct ezrin interactions promote PTH1R apical localization and signaling in LLC-PK1 cells.
PTHLH and PTHR1 were evaluated as functional candidate genes for their effects on number and shape of teats in pigs
The protein encoded by this gene is a member of the G-protein coupled receptor family 2. This protein is a receptor for parathyroid hormone (PTH) and for parathyroid hormone-like hormone (PTHLH). The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system. Defects in this receptor are known to be the cause of Jansen's metaphyseal chondrodysplasia (JMC), chondrodysplasia Blomstrand type (BOCD), as well as enchodromatosis. Two transcript variants encoding the same protein have been found for this gene.
, PTH/PTHrP type I receptor
, PTH1 receptor
, parathyroid hormone receptor 1
, parathyroid hormone/parathyroid hormone-related peptide receptor
, parathyroid hormone/parathyroid hormone-related protein receptor
, seven transmembrane helix receptor
, PTH-related peptide receptor
, PTH/PTHrP receptor
, parathyroid hormone 1 receptor
, parathyroid hormone/parathyroid hormone-related peptide receptor-like
, parathyroid hormone receptor-1
, parathyroid receptor
, LOW QUALITY PROTEIN: parathyroid hormone/parathyroid hormone-related peptide receptor
, Parathyroid hormone/parathyroid hormone-related peptide receptor