Browse our Aryl Hydrocarbon Receptor Proteins (AHR)

Xenopus laevis Aryl Hydrocarbon Receptor (AHR) interaction partners

1. Identified structural features of AHR1beta associated with low TCDD sensitivity. Substitution of the entire ligand binding domain with the corresponding sequence from mouse AHR(b-1) dramatically increased TCDD responsiveness in transactivation assays.

Medaka Aryl Hydrocarbon Receptor (AHR) interaction partners

1. Transient AHR activation and cytochrome P450 1A (CYP1A) induction in livers occurred during ANIT-induced hepatobiliary impairment in medaka.

Human Aryl Hydrocarbon Receptor (AHR) interaction partners

1. Expression of microRNA potentially regulated by AhR and CAR in malignant tumors of the endometrium has been reported.

2. The overexpression and activation of AHR are involved in the early development of skin squamous cell carcinomas. AHR expression correlates with EGFR expression and may influence cell proliferation.

3. These studies identified SNPs that were cis-eQTLs for DEFB1 and AHR and, which were associated with variation in plasma KYN concentrations that were related to severity of major depressive disordersymptoms.

4. rs2470893 SNP, which maps 196 bp from a CYP1A1 promoter XRE, is associated with variations in 3MC-dependent AHR binding and CYP1A1 expression.

5. WASH-mediated AHR expression has a critical function in the maintenance of NKp46+ innate lymphoid cells

6. the protective role of AhR in intestinal barrier function

7. Elevated AhR expression may be involved in the progression of tissue remodeling in chronic rhinosinusitis without nasal polyp without allergic rhinitis similar to TGF-beta1 expression. Conversely, lower AhR expression may be involved in allergic reactions in chronic rhinosinusitis with nasal polyp with allergic rhinitis.

8. These results suggest that D-Kyn increases lung cancer cells to metastasize by activating Ahr.

9. The role of IDO1-IDO2-AHR pathway in the TLR4-induced tolerogenic phenotype in human dendritic cells has been reported.

10. The association between AHR Arg55Lys polymorphism and male infertility risk was not confirmed (Meta-Analysis)

11. A meta-analysis of five sets of data evaluated the association of aryl hydrocarbon receptor 1661G>A with male infertility.

12. IDO decreased glycolysis and glutaminolysis by activating GCN2K, resulting in activation of AMPactivated protein kinase.

13. AHR inhibition or knockdown/knockout consistently reduced human ER-/PR-/Her2- and inflammatory breast cancer cell invasion, migration, and metastasis. This was associated with a decrease in invasion-associated genes (e.g., Fibronectin, VCAM1, Thrombospondin, MMP1) and an increase in CDH1/E-cadherin, previously associated with decreased tumor aggression.

14. This study demonstrated that the regulation of AHR expression by miR124 is critical to the development of inflammatory response in chronic rhinosinusitis with nasal polyps.

15. In human keratinocytes, authors found that perillaldehyde (1) inhibited BaP-induced AHR activation and ROS production, (2) inhibited BaP/AHR-mediated release of the CCL2 chemokine, and (3) activated the NRF2/HO1 antioxidant pathway.

16. Infants born to women with specific AHR and XRCC1 genotypes may have higher genetic risks for birth weight reduction

17. ITE suppresses growth of human pulmonary artery endothelial cells independent of AhR

18. High AHR expression is associated with nerve sheath tumorigenesis.

19. IRES (ribosome entry site)activity is increased in the PTX-resistant ovarian cancer cells in which AHR protein expression was also enhanced. These results strongly suggest an important role for AHR ribosome entry site (IRES)-dependent translation mechanism in cancer cell response to paclitaxel treatment

20. AhR activation by FICZ reduces FcepsilonRI and upregulates IDO expression in Langerhans cells. This AhR-mediated anti-inflammatory feedback mechanism may dampen the allergen-induced inflammation in atopic dermatitis.

Pig (Porcine) Aryl Hydrocarbon Receptor (AHR) interaction partners

1. homology models of the porcine AhR-ligand binding domain (LBD) and the porcine aryl hydrocarbon receptor nuclear translocator-ligand binding domain (ARNT-LBD) were created.

2. steroid hormones, AhR and estrogen receptor beta are affected by TCDD and genistein in granulosa cells of medium porcine follicles

3. AHR mRNA expression in follicular, theca, and granulosa cells suggest the involvement of AHR in the modulation of reproductive processes in the porcine ovary.

Mouse (Murine) Aryl Hydrocarbon Receptor (AHR) interaction partners

1. Distribution of parent PCB congeners also varied by genotype with strikingly high levels of PCB 77 in poor-affinity Ahr (d) Cyp1a2(-/-) while Ahr (b) Cyp1a2(+/+) mice effectively sequestered coplanar PCBs in the liver.

2. these data support a prominent role for the AhR in regulating lung miRNA expression.

3. In air-exposed airway epithelia, induction of factors required for multiciliogenesis, including cyclin O (Ccno) and Multicilin (Mcidas), is AhR dependent, and air exposure induces AhR binding to the Ccno promoter. Submersion and hypoxic conditions impede AhR-dependent Ccno induction.

4. Shared epitope-aryl hydrocarbon receptor crosstalk underlies the mechanism of gene-environment interaction in autoimmune arthritis.

5. airway inflammatory cells and cytokines present in BALF and TRIF in lung tissue play a role in inducing AHR and airway inflammation upon RSV and bacteria coinfection

6. Ectopic activation of AHR during early differentiation disrupts the differentiation program via the chromatin remodeling complex NuRD.

7. AhR activation ameliorated epithelial barrier dysfunction following intestinal ischemia/reperfusion and hypoxia through upregulation of Notch1 signaling.

8. Low AHR expression is associated with provokes locomotor defects and alteration of myelin structure.

9. Data indicate aryl hydrocarbon receptor (AhR) and small heterodimer partner (SHP) as new physiological regulators of phosphatidylcholines (PC) and S-adenosylmethionine (SAM) levels.

10. These results suggested that AhR deficiency resulted in increased susceptibility to colitis, whereas activation of AhR by FICZ could ameliorate DSSinduced colitis via the MK2/pMK2/TTP pathway.

11. These results validate the role of the AhR pathway in regulating choroidal neovascular pathogenesis, identify mechanisms of AhR-based therapies in the eye, and argue in favor of developing AhR as a drug target for the treatment of neovascular AMD.

12. Deletion of the Ahr gene in cardiomyocytes protects males from heart dysfunction due to NKX2.5 haploinsufficiency.

13. Identify Cxcl5 as a novel target of AHR-mediated gene expression in primary mouse keratinocytes.

14. this study shows that tryptophan metabolite activation of the aryl hydrocarbon receptor regulates IL-10 receptor expression on intestinal epithelia

15. Ambient particulate matter enhances dendritic cell activation that primes naive T cell differentiation towards a Th17-like phenotype in an AhR-dependent manner.

16. AHR role in the acute lethal pulmonary inflammation

17. These findings highlight the physiologic importance of cell-type specific balancing of AhR/AhRR expression in response to microbial, nutritional and other environmental stimuli. Specifically, AhRR contributes to the maintenance of colonic intraepithelial lymphocytes and prevents excessive IL-1beta production and Th17/Tc17 differentiation. In contrast, the AhRR enhances IFN-gamma-production by effector T cells in the in...

18. these data support that RelB suppresses cigarette smoke-induced apoptosis, potentially by increasing the AhR

19. Results elucidate the dimerization process of AhR with ARNT and propose the structure of the N-terminal region of the AhR:ARNT dimer including the bHLH, PAS-A and PAS-B domains.

20. the AhR pathway is much more that a xenobiotic metabolism-inducing pathway, and the regulation by AhR of Notch signaling in the testis offers some insight into the mechanism of infertility in men.