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Human Aryl Hydrocarbon Receptor Protein expressed in Wheat germ - ABIN1344642
van den Bogaard, Bergboer, Vonk-Bergers, van Vlijmen-Willems, Hato, van der Valk, Schröder, Joosten, Zeeuwen, Schalkwijk: Coal tar induces AHR-dependent skin barrier repair in atopic dermatitis. in The Journal of clinical investigation 2013
Show all 2 Pubmed References
Identified structural features of AHR1beta associated with low TCDD sensitivity. Substitution of the entire ligand binding domain with the corresponding sequence from mouse AHR(b-1) dramatically increased TCDD responsiveness in transactivation assays.
Transient AHR activation and cytochrome P450 1A (CYP1A) induction in livers occurred during ANIT-induced hepatobiliary impairment in medaka.
hypoxia is capable of promoting the Th17 response by reducing AhR activity via HIF-1alpha activity.
This review will discuss the growing body of literature that provides evidence that the AhR protects the lungs against the damaging effects of cigarette smoke.
Results show that environmentally persistent free radicals (EPFR) increase aryl hydrocarbon receptor activation and reactive oxygen species (ROS) production in human bronchial epithelial cells. While AhR activation was correlated with an increased expression of oxidant-producing enzymes, it is possible that AhR activation is both a cause and effect of EPFR-induced ROS.
Mutant AHR failed to promote 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD)-induced xenobiotic responsive element (XRE) luciferase activity. In parallel, mutation in AHR abolished activation of its downstream target gene, such as CYP1A1 and CYP1A2
we found a constitutive nuclear localization of AhR in every placental model, in the absence of any voluntarily-added exogenous activator. Our data suggest an intrinsic activation of AhR due to the presence of endogenous placental ligands.
AHR protein levels were upregulated in all grades of meningioma compared to control meninges. As the grade of the meningioma progresses from low to high grade we also observed that AHR protein levels were upregulated significantly, indicating an important role of AHR in meningioma tumor progression.
The aim of this study was to investigate serum concentrations of AhR, cytochromes P450 (CYP) 1A1 and 1B1 in patients with exacerbated psoriasis vulgaris.
AhR p.Arg554Lys polymorphism, alone and in combination with parental exposures, is associated with the congenital heart disease risk.
AhR is higher expressed in short androgen receptor (AR) poly-glutamine polymorphism (AR-Q) tumour compared to that in long AR-Q patient.
This study evaluated the mechanism by which p23 triggers degradation of AHR, and the role of HSP90 in this process.
The compound leads, 4-Me-indole and 7-MeO-indole, induced substantial nuclear translocation of the AhR.
To study the potential role of AHR pathway in CML progenitors and stem cells, we have first evaluated the expression of AHR in UT-7 cell line expressing BCR-ABL. AHR expression was highly reduced in UT-7 cell expressing BCR-ABL as compared to controls.
Altogether, our data suggest that a transcriptional defect of AhR could be a susceptibility factor for the development of vitiligo.
AhR activation in macrophages causes a block to HIV-1 and HSV-1 replication.
These findings suggest that Malassezia pachydermatis infection of human keratinocytes induces activation of the AhR, and increases the expression of its responsive genes, including CYP1A1.
The author's observations point to a possible effect of local AhR ligands in the regulation of the function of CD56(bright) tissue-resident or intratumoral NK cells.
AHR pathway is activated both in chronic kidney disease and could be a key mechanism involved in the deleterious cardiovascular effects observed in CKD.
Expression of microRNA potentially regulated by AhR and CAR in malignant tumors of the endometrium has been reported.
The overexpression and activation of AHR are involved in the early development of skin squamous cell carcinomas. AHR expression correlates with EGFR expression and may influence cell proliferation.
These studies identified SNPs that were cis-eQTLs for DEFB1 and AHR and, which were associated with variation in plasma KYN concentrations that were related to severity of major depressive disordersymptoms.
homology models of the porcine AhR-ligand binding domain (LBD) and the porcine aryl hydrocarbon receptor nuclear translocator-ligand binding domain (ARNT-LBD) were created.
steroid hormones, AhR and estrogen receptor beta are affected by TCDD and genistein in granulosa cells of medium porcine follicles
AHR mRNA expression in follicular, theca, and granulosa cells suggest the involvement of AHR in the modulation of reproductive processes in the porcine ovary.
activation of the AHR pathway in intestinal epithelial cells guards the stem cell niche to maintain intestinal barrier integrity.
Results provide evidence that NRF2 and AhR cooperate to regulate numerous antioxidant gene expression in response to 2,3,7,8-tetrachlorodibenzo-p-dioxin.
Comparing with wild-type mouse, Ahr knockout mice exhibited reduced electroretinogram responses at 9 months of age. Retinal histology revealed retinal histology showed the degeneration of photoreceptors with a thinner outer nuclear layer. Thus, our data demonstrate that AHR is associated with Retinitis pigmentosa
AhR plays a pivotal role in the regulation of hippocampal function, by controlling hippocampal granule neuron morphology and synaptic maturation.
The activity of kynurenine is increased 100-1000-fold by incubation or long-term storage and relies on the hydrophobic ligand-binding pocket of AHR.
Distribution of parent PCB congeners also varied by genotype with strikingly high levels of PCB 77 in poor-affinity Ahr (d) Cyp1a2(-/-) while Ahr (b) Cyp1a2(+/+) mice effectively sequestered coplanar PCBs in the liver.
these data support a prominent role for the AhR in regulating lung miRNA expression.
In air-exposed airway epithelia, induction of factors required for multiciliogenesis, including cyclin O (Ccno) and Multicilin (Mcidas), is AhR dependent, and air exposure induces AhR binding to the Ccno promoter. Submersion and hypoxic conditions impede AhR-dependent Ccno induction.
Shared epitope-aryl hydrocarbon receptor crosstalk underlies the mechanism of gene-environment interaction in autoimmune arthritis.
airway inflammatory cells and cytokines present in BALF and TRIF in lung tissue play a role in inducing AHR and airway inflammation upon RSV and bacteria coinfection
Ectopic activation of AHR during early differentiation disrupts the differentiation program via the chromatin remodeling complex NuRD.
AhR activation ameliorated epithelial barrier dysfunction following intestinal ischemia/reperfusion and hypoxia through upregulation of Notch1 signaling.
Low AHR expression is associated with provokes locomotor defects and alteration of myelin structure.
Data indicate aryl hydrocarbon receptor (AhR) and small heterodimer partner (SHP) as new physiological regulators of phosphatidylcholines (PC) and S-adenosylmethionine (SAM) levels.
These results suggested that AhR deficiency resulted in increased susceptibility to colitis, whereas activation of AhR by FICZ could ameliorate DSSinduced colitis via the MK2/pMK2/TTP pathway.
These results validate the role of the AhR pathway in regulating choroidal neovascular pathogenesis, identify mechanisms of AhR-based therapies in the eye, and argue in favor of developing AhR as a drug target for the treatment of neovascular AMD.
Deletion of the Ahr gene in cardiomyocytes protects males from heart dysfunction due to NKX2.5 haploinsufficiency.
Identify Cxcl5 as a novel target of AHR-mediated gene expression in primary mouse keratinocytes.
this study shows that tryptophan metabolite activation of the aryl hydrocarbon receptor regulates IL-10 receptor expression on intestinal epithelia
This gene encodes a ligand-activated transcription factor involved in the regulation of biological responses to planar aromatic hydrocarbons. This receptor has been shown to regulate xenobiotic-metabolizing enzymes such as cytochrome P450. Its ligands included a variety of aromatic hydrocarbons.
aryl hydrocarbon receptor
, aryl hydrocarbon receptor 1
, aryl hydrocarbon receptor-like
, ah receptor
, aromatic hydrocarbon receptor
, class E basic helix-loop-helix protein 76
, Ah receptor
, dioxin receptor