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Human Aryl Hydrocarbon Receptor Protein expressed in Wheat germ - ABIN1344642
van den Bogaard, Bergboer, Vonk-Bergers, van Vlijmen-Willems, Hato, van der Valk, Schröder, Joosten, Zeeuwen, Schalkwijk: Coal tar induces AHR-dependent skin barrier repair in atopic dermatitis. in The Journal of clinical investigation 2013
Show all 2 Pubmed References
Identified structural features of AHR1beta associated with low TCDD sensitivity. Substitution of the entire ligand binding domain with the corresponding sequence from mouse AHR(b-1) dramatically increased TCDD responsiveness in transactivation assays.
Transient AHR activation and cytochrome P450 1A (CYP1A) induction in livers occurred during ANIT-induced hepatobiliary impairment in medaka.
These results suggest that D-Kyn increases lung cancer cells to metastasize by activating Ahr.
The role of IDO1 (show IDO1 Proteins)-IDO2 (show IDO2 Proteins)-AHR pathway in the TLR4 (show TLR4 Proteins)-induced tolerogenic phenotype in human dendritic cells has been reported.
The association between AHR Arg55Lys polymorphism and male infertility risk was not confirmed (Meta-Analysis)
A meta-analysis of five sets of data evaluated the association of aryl hydrocarbon receptor 1661G>A with male infertility.
IDO decreased glycolysis and glutaminolysis by activating GCN2K, resulting in activation of AMPactivated protein kinase.
AHR inhibition or knockdown/knockout consistently reduced human ER-/PR-/Her2 (show ERBB2 Proteins)- and inflammatory breast cancer cell invasion, migration, and metastasis. This was associated with a decrease in invasion-associated genes (e.g., Fibronectin (show FN1 Proteins), VCAM1 (show VCAM1 Proteins), Thrombospondin, MMP1 (show MMP1 Proteins)) and an increase in CDH1/E-cadherin (show CDH1 Proteins), previously associated with decreased tumor aggression.
This study demonstrated that the regulation of AHR expression by miR124 is critical to the development of inflammatory response in chronic rhinosinusitis with nasal polyps.
In human keratinocytes, authors found that perillaldehyde (1) inhibited BaP (show PHB2 Proteins)-induced AHR activation and ROS (show ROS1 Proteins) production, (2) inhibited BaP (show PHB2 Proteins)/AHR-mediated release of the CCL2 (show CCL2 Proteins) chemokine (show CCL1 Proteins), and (3) activated the NRF2 (show GABPA Proteins)/HO1 (show HMOX1 Proteins) antioxidant pathway.
Infants born to women with specific AHR and XRCC1 (show XRCC1 Proteins) genotypes may have higher genetic risks for birth weight reduction
ITE suppresses growth of human pulmonary artery endothelial cells independent of AhR
homology models of the porcine AhR-ligand binding domain (LBD) and the porcine aryl hydrocarbon receptor nuclear translocator (show ARNT Proteins)-ligand binding domain (ARNT (show ARNT Proteins)-LBD) were created.
steroid hormones, AhR and estrogen receptor beta (show ESR2 Proteins) are affected by TCDD and genistein in granulosa cells of medium porcine follicles
AHR mRNA expression in follicular, theca, and granulosa cells suggest the involvement of AHR in the modulation of reproductive processes in the porcine ovary.
Distribution of parent PCB (show PC Proteins) congeners also varied by genotype with strikingly high levels of PCB (show PC Proteins) 77 in poor-affinity Ahr (d) Cyp1a2 (show CYP1A1 Proteins)(-/-) while Ahr (b) Cyp1a2 (show CYP1A1 Proteins)(+/+) mice effectively sequestered coplanar PCBs in the liver.
these data support a prominent role for the AhR in regulating lung miRNA expression.
In air-exposed airway epithelia, induction of factors required for multiciliogenesis, including cyclin O (Ccno (show CCNO Proteins)) and Multicilin (show MCIN Proteins) (Mcidas), is AhR dependent, and air exposure induces AhR binding to the Ccno (show CCNO Proteins) promoter. Submersion and hypoxic conditions impede AhR-dependent Ccno (show CCNO Proteins) induction.
Shared epitope-aryl hydrocarbon receptor crosstalk underlies the mechanism of gene-environment interaction in autoimmune arthritis.
airway inflammatory cells and cytokines present in BALF and TRIF (show RNF138 Proteins) in lung tissue play a role in inducing AHR and airway inflammation upon RSV and bacteria coinfection
Ectopic activation of AHR during early differentiation disrupts the differentiation program via the chromatin remodeling complex NuRD.
AhR activation ameliorated epithelial barrier dysfunction following intestinal ischemia/reperfusion and hypoxia through upregulation of Notch1 (show NOTCH1 Proteins) signaling.
Low AHR expression is associated with provokes locomotor defects and alteration of myelin structure.
Data indicate aryl hydrocarbon receptor (AhR) and small heterodimer partner (SHP (show NR0B2 Proteins)) as new physiological regulators of phosphatidylcholines (PC) and S-adenosylmethionine (SAM (show TTN Proteins)) levels.
These results suggested that AhR deficiency resulted in increased susceptibility to colitis, whereas activation of AhR by FICZ could ameliorate DSSinduced colitis via the MK2 (show KCNA2 Proteins)/pMK2/TTP (show ZFP36 Proteins) pathway.
This gene encodes a ligand-activated transcription factor involved in the regulation of biological responses to planar aromatic hydrocarbons. This receptor has been shown to regulate xenobiotic-metabolizing enzymes such as cytochrome P450. Its ligands included a variety of aromatic hydrocarbons.
aryl hydrocarbon receptor
, aryl hydrocarbon receptor 1
, aryl hydrocarbon receptor-like
, ah receptor
, aromatic hydrocarbon receptor
, class E basic helix-loop-helix protein 76
, Ah receptor
, dioxin receptor