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Nuclear overexpression of OLC1 was associated with clinicopathological parameters and could predict a poor overall survival in gastric adenocarcinoma.
The expression of OLC1 in the tumor tissues of lung adenocarcinoma is higher than that in squamous cell carcinoma.
Structural and biochemical studies reveal an unusually tight interaction between ULK3 (show ULK3 Proteins) and IST1, an ESCRT-III subunit required for cytokinetic abscission.
Crystal structures of three molecular complexes reveal that IST1 binds to the MIT domains of VPS4 and LIP5.
Overexpression of OLC1 promotes tumorigenesis of human esophageal squamous cell carcinoma.
Findings indicate that a high expression level of overexpressed in lung cancer 1 (OLC1) serves as a biomarker for poor prognosis for breast cancer, suggesting that OLC1 may be a potential target of antiangiogenic therapy for breast cancer.
the binding of ALG-2 (show PDCD6 Proteins) to IST1 is Ca(2 (show CA2 Proteins)+)-dependent
The results suggest that inclusion of IST1 into the ESCRT complex allows recruitment of spastin (show SPAST Proteins) to promote fission of recycling tubules from the endosome.
OLC1 over-expression is an important factor in epithelial ovarian carcinoma prognosis and can be a potential biomarker for ovarian carcinoma.
The interaction between CL7MIT and CHMP1B and between CL7MIT and IST1 became stronger when IST1 or CHMP1B was additionally coexpressed, suggesting formation of ternary complex of calpain-7, IST1 and CHMP1B.
This gene encodes a protein with MIT-interacting motifs that interacts with components of endosomal sorting complexes required for transport (ESCRT). ESCRT functions in vesicle budding, such as that which occurs during membrane abscission in cytokinesis. There is a pseudogene for this gene on chromosome 19. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
, MAPK activating protein PM28
, overexpressed in lung cancer 1
, putative MAPK-activating protein PM28
, KIAA0174-like protein
, increased sodium tolerance 1 homolog S homeolog
, increased sodium tolerance 1 homolog