Use your antibodies-online credentials, if available.
No Products on your Comparison List.
Your basket is empty.
Find out more
Show all synonyms
Select your origin of interest
OPN play a role in pathogenesis of neurodegenerative diseases or in neuroprotection by regulating the activation and function of microglia.
osteopontin has a role in DNA repair and impact on human glioblastoma radiosensitivity
SPP1 promoted the metastasis of CRC (show CALR Proteins).
Results show that osteopontin is positively associated with hepatocellular carcinoma (HCC (show FAM126A Proteins)) metastasis, and that OPN can activate CCR1 expression through the PI3K (show PIK3CA Proteins)/AKT (show AKT1 Proteins)/HIF-1a (show HIF1A Proteins) signaling pathway to promote HCC (show FAM126A Proteins) progression and metastasis.
This review presents the current knowledge on the expression profiles of OPN and its main splice variants in human cancers, as well as the potential implications in patient outcome. [review]
Strong correlations between the expression of type I, II, IV collagen and osteopontin and the clinical stage of tympanosclerosis indicate the involvement of these proteins in excessive fibrosis and pathological remodeling of the tympanic membrane.
result of this study confirms that increased levels of OPN exist in CSF (show CSF2 Proteins) and peripheral blood of MS patients and strengthens the evidence regarding the clinical utility of OPN as a promising and validated biomarker for MS
OPN overexpression was correlated with poor overall survival and clinical features reflecting high aggressiveness in patients with gastric cancer.
ITGbeta3 and CD44 (show CD44 Proteins) expression levels determine whether OPN-a inhibits or enhances growth in lung cancer cells.
Study identified that miR (show MLXIP Proteins)-127-5p targets the 3' UTR of osteoarthritis (OA) mRNA to down-regulate the expression of OPN. In OA, the down-expressed miR (show MLXIP Proteins)-127-5p allows the expression of OPN, which mediates the establishment and development of OA.
The findings reveal that hepatic OPN contributes to cholesterol gallstone formation by regulating biliary metabolism and might be developed as a therapeutic target for gallstone treatments.
Endogenous OPN emerges as a key player in the pathogenesis of chronic Chagas heart disease, through the upregulation of myocardial CCL5 (show CCL5 Proteins)/MMP-2 (show MMP2 Proteins) expression and activities resulting in pro-inflammatory and pro-hypertrophic events, cardiac remodeling and interstitial fibrosis.
In this study, the effect of deficiency of OPN on intestinal tumor development in Apc (show APC Proteins)-deficient Min mice was investigated.At 16 weeks of age, the number of small intestinal polyps in Min/OPN(+/-) and Min/OPN(-/-) mice was lower than that of Min/OPN(+/+) mice. Colorectal tumor incidences and multiplicities in Min/OPN(+/-) and Min/OPN(-/-) mice were significantly lower than those in Min/OPN(+/+) mice
Osteopontin RNA aptamer is a novel and effective approach for preventing cardiac hypertrophy and fibrosis, improving cardiac function, and reversing pressure overload-induced heart failure.
OPN deficiency reduced the incidence of chemically induced HCC (show FAM126A Proteins) by suppressing EGFR (show EGFR Proteins)-mediated anti-apoptotic signaling.
In experimental autoimmune encephalomyelitis treated with interferon-beta (show IFNB1 Proteins), OPN was significantly decreased in splenocyte supernatants. Neutralizing OPN antibodies offset the inhibitory effect of IFN-beta (show IFNB1 Proteins) on Th17 cells. IFN-beta (show IFNB1 Proteins) influenced the acetylation of the Opn gene promoter. IFN-beta (show IFNB1 Proteins) plays a role in Th17 differentiation partly through the inhibition of OPN.
Osteopontin plays a key role in vascular smooth muscle cell via signaling pathways involving AP-1 (show JUN Proteins) and C/EBP beta (show CEBPB Proteins), leading to increases in vascular smooth muscle cell proliferation and subsequent vascular remodeling.
we disclosed the role of chemotaxis and apoptosis in the fibrotic microenvironment-enhanced seeding of tumor cells and identified the fibroblast-derived FN1 (show FN1 Proteins) and SPP1 as the central mediators in these processes
Data show that, together, osteocalcin (OC (show BGLAP Proteins)) and osteopontin (OPN) play important roles in determining bone size, shape, and strength.
Results show that BSP (show KLK6 Proteins) and OPN are present in the mineralized tissues of fibrocartilaginous enthuses.
This implies that a majority of the acidic residues within OPN must be engaged in calcium interaction under physiological conditions.
Genetic variations in the SPP1 promoter affect gene expression and the level of osteopontin secretion into bovine milk.
Osteopontin, osteocalcin and OB-cadherin expression in Synthetic nanohydroxyapatite vs bovine hydroxyapatite cultured Osteoblastic-like cells.
osteopontin (OPN) can serve as a process-directing agent for the intrafibrillar mineralization of collagen.
Results suggest a mechanism of the interaction of UO2(2+) with bone metabolism and a new role for osteopontin (OPN) as a metal transporter.
Upon induction of luteolysis, SPP1 serves as a signaling molecule to recruit or activate immune cells to facilitate luteal regression and tissue degradation.
OPN strongly reduces the amount of biofilm formed in a well-defined laboratory model of acidogenic dental biofilm.
This study demonstrates that adhesion of isolated neonatal rat osteoclasts in vitro was augmented on bovine milk osteopontin (bmOPN) with post-translational modifications (PTMs) compared to human Escherichia-coli-derived recombinant OPN without PTMs.
topographical distribution of both the in vivo and in vitro phosphorylation sites of bone sialoprotein (show CRISP1 Proteins)
the bovine osteopontin gene has two functionally distinct clusters of haplotypes within the QTL region on chromosome 6
These data suggested that methylation in the OPN promoter plays a crucial role in the regulation of OPN expression that we found in cloned pigs genome.
The striking breed differences between hyperprolific Large White and Meishanin pigs of secreted phospoprotein 1 expression in endometrium suggest that SPP1 may be associated with placental efficiency.
Microglia incubated in vitro with different concentrations (0.1 fM-1 nM) of recombinant osteopontin showed increased proliferation at 10 fM.
results of this study reveal faster growth rate and differences in pig productivity according to genotypes of the SPP1 gene
Osteopontin could play an important role in the development of neointimal hyperplasia in venous conduits after coronary artery bypass grafting.
A different MSSCP pattern was shown in osteopontin which indicates that mutation is located in promotor region; the A --> G transitions was identified in two positions -617 and -608
The 3' terminal end of the first intron of porcine SPP1 harbors a C/EBPbeta (show CEBPB Proteins) binding site and this binding site is negatively affected by the mutant G allele.
in pregnant pigs SPP1 is induced by conceptus estrogen in uterine luminal epithelium and is regulated in a manner coincident with placental progesterone production
osteopontin promotes pathologic mineralization via calcium pyrophosphate dihydrate crystal formation in articular cartilage.
Osteopontin is detected in the majority of germ cells and is involved in spermatogenesis in boar testis.
Infection of urinary tract by Escherichia coli caused higher than normal expression of promoter protein osteopontin and mucosal damage at renal tubular cells.
The SPP1 was principally expressed in motor neurons in lamina IX of the macaque spinal cord.The expression level varied among different spinal segments and correlated positively with neuron size.
results demonstrate that SPP1 is expressed in corticospinal tract neurons in M1 and several other sensorimotor cortices
The protein encoded by this gene is involved in the attachment of osteoclasts to the mineralized bone matrix. The encoded protein is secreted and binds hydroxyapatite with high affinity. The osteoclast vitronectin receptor is found in the cell membrane and may be involved in the binding to this protein. This protein is also a cytokine that upregulates expression of interferon-gamma and interleukin-12. Several transcript variants encoding different isoforms have been found for this gene.
, early T-lymphocyte activation 1
, osteopontin/immunoglobulin alpha 1 heavy chain constant region fusion protein
, secreted phosphoprotein 1 (osteopontin, bone sialoprotein I, early T-lymphocyte activation 1)
, urinary stone protein
, 44 kDa bone phosphoprotein
, bone sialoprotein 1
, calcium oxalate crystal growth inhibitor protein
, early T-lymphocyte activation 1 protein
, osteopontin-like protein
, Sialoprotein (osteopontin)
, bone sialoprotein I
, spp1 protein
, secreted phosphoprotein-1
, LOW QUALITY PROTEIN: osteopontin
, Bone sialoprotein 1