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determined the crystal structure of the tandem Ig4-5 domains (D4-5) of human Robo2 and found that a hydrophobic surface on D4 mediates close homotypic contacts with a reciprocal D4
human placental multipotent mesenchymal stromal cell express Slit2 (show SLIT3 Proteins) and both Robo1 (show ROBO1 Proteins) and Robo4 (show ROBO4 Proteins) are present in human umbilical vein endothelial cells.
ROBO2 variants were not found to be associated with nonsyndromic vesicoureteral reflux with or without renal hypoplasia/dysplasia, providing further evidence for genetic heterogeneity
ROBO2 and RASSF2A gene methylations may be related to gastric tumorigenesis, and ROBO2 gene methylation is associated with sporadic gastric cancer.
Overexpression of ROBO2 induces its tumor suppressive effects in Breast cancer
ROBO2 somatic mutation is associated with myelodysplastic syndrome progression. Overexpression of ROBO2 produces anti-proliferative and pro-apoptotic effects in leukemia cells. This effect was lost in ROBO mutants and ROBO-SLIT2 signaling is impaired.
Common variation near ROBO2 is associated with expressive vocabulary in infancy.
Mutations of the SLIT2 (show SLIT3 Proteins)-ROBO2 pathway genes SLIT2 (show SLIT3 Proteins) and SRGAP1 (show SRGAP1 Proteins) confer risk for congenital anomalies of the kidney and urinary tract
Down-regulation of ROBO2 expression is associated with prostate cancers.
Frameshift mutations of ROBO1 (show ROBO1 Proteins) and ROBO2 genes and alteration of ROBO2 expression in gastric and colorectal cancers suggest that both genes might play roles in the pathogenesis of both cancers.
repulsive Slit-Robo2-Ena signaling exerts an extrusive force downstream of JNK (show MAPK8 Proteins) to eliminate scrib cells from epithelia by disrupting E-cadherin (show CDH1 Proteins).
The authors describe a distinct mechanism to inhibit Robo1 repulsion and promote midline crossing, in which Roundabout2 (Robo2) binds to and prevents Robo1 signaling.
a Robo2-mediated mechanism, independent of signaling, is essential to limiting Slit distribution and which might be relevant to the regulation of Slit-mediated short-range signaling in additional systems
Data identify Robo2 and Robo3 (show ROBO3 Proteins) as key effectors of Hb9 (show MNX1 Proteins) in regulating nervous system development.
Data show that Robo and Robo2 promote midline repulsion, while Robo2 and Robo3 (show ROBO3 Proteins) specify the position of longitudinal axon pathways.
Study found that lateral positioning does not rely on structural differences between the Robo1 (show ROBO1 Proteins) and Robo2 receptors-neither in their ectodomain nor cytoplasmic domains instead expression differences alone can account for lateral pathway selection.
At the CNS midline, Slit functions as a repellent for tracheal branches and this function is mediated primarily by Robo. Robo2 is necessary for the tracheal response to the attractive Slit signal and its function is antagonized by Robo.
robo, robo2, and robo3 (show ROBO3 Proteins) play a role in the guidance of sensory axons in the Drosophila embryo by both slit-dependent and slit-independent mechanisms.
axon guidance molecules roundabout2 and roundabout3 (robo2/3) are necessary for serotonergic neuron differentiation
midline-secreted Slit activates Robo/Robo2 signalling to control the migration of the vmd1a sensory precursor cells
Genetic analysis showed that Caspase-3 (show CASP3 Proteins), Caspase-9 (show CASP9 Proteins), and p38 MAPK (show MAPK14 Proteins) interacted with Slit1a-Robo2 signaling.
The N-terminal domain unique to Robo3a (show ROBO3 Proteins).1 mediates blockade of Robo2 repulsive activity.
Robo2-Slit and Dcc (show DCC Proteins)-Netrin1 coordinate the axonal projection choices of neurons developing in the forebrain.
These results reveal that subtype-specific activity of Robo2 regulates subcircuit morphogenesis in the trigeminal sensory system.
Increased arborization in robo2 mutants was phenocopied by dominant-negative Robo2 expressed in single retinal ganglion cells and rescued by full-length Robo2, indicating that Robo2 acts cell-autonomously.
Robo2 acted initially to split the tract of the postoptic commissure into discrete fascicles upon entering a broad domain of Slit1a expression in the ventrocaudal diencephalon.
Here the authors find that the developmental axon guidance receptor Roundabout 2 (Robo2) is critical for the maintenance of inhibitory synapses in the adult ventral tegmental area (VTA), a brain region important for the production of the neurotransmitter dopamine.
While Slit1 (show SLIT1 Proteins) and Robo2 are only expressed in peripheral axons and their cell bodies, Slit2 (show SLIT2 Proteins), Slit3 (show SLIT3 Proteins) and Robo1 (show ROBO1 Proteins) are also expressed in satellite cells of the dorsal root ganglion, Schwann cells and fibroblasts of peripheral nerves.
Robo1 (show ROBO1 Proteins)/2 regulate follicle atresia through manipulating granulosa cell apoptosis in mice
Roundabout receptor (Robo) genes are expressed in pulmonary neuroendocrine cells (PNECs), a rare, innervated epithelial population. Robo inactivation in mouse lung results in an inability of PNECs to cluster into sensory organoids and triggers increased neuropeptide production upon exposure to air.
Loss of Robo2 resulted in a failure of the normal separation of the mesenchyme from the Wolffian duct/ureteric epithelium.
Mutations of the SLIT2 (show SLIT2 Proteins)-ROBO2 pathway genes SLIT2 (show SLIT2 Proteins) and SRGAP1 (show SRGAP1 Proteins) confer risk for congenital anomalies of the kidney and urinary tract
Slit2 (show SLIT2 Proteins) signaling through Robo1 (show ROBO1 Proteins) and Robo2 has a role in retinal neovascularization
Mycbp2 and Robo2 were found to cooperate within a genetic network that has profound effects on axon guidance
Report role of Robo2 in development of the caval veins and pericardium.
Inactivation of Robo 2 leads to mispositioning of the stomach in the thoracic instead of the abdominal cavity, which likely contributes to poor lung inflation and lethality at birth, reminiscent of congenital diaphragmatic hernia.
This gene belongs to the ROBO family, part of the immunoglobulin superfamily proteins that are highly conserved from fly to human. The encoded protein is a receptor for SLIT2, molecules known to function in axon guidance and cell migration. Defects in this gene are the cause of vesicoureteral reflux type 2. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
roundabout homolog 2
, roundabout 2 precursor
, Roundabout2 protein
, roundabout, axon guidance receptor, homolog 2 (Drosophila)
, roundabout, axon guidance receptor, homolog 2
, roundabout homolog 2-like
, SGP cluster fusion defects 4
, roundabout 2
, Robo 2
, LOW QUALITY PROTEIN: roundabout homolog 2