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Human Polyclonal Caveolin 2 Primary Antibody for ICC, IF - ABIN4288380
Codenotti, Vezzoli, Poliani, Cominelli, Bono, Kabbout, Faggi, Chiarelli, Colombi, Zanella, Biasiotto, Montanelli, Caimi, Monti, Fanzani: Caveolin-1, Caveolin-2 and Cavin-1 are strong predictors of adipogenic differentiation in human tumors and cell lines of liposarcoma. in European journal of cell biology 2016
Cow (Bovine) Polyclonal Caveolin 2 Primary Antibody for IHC, WB - ABIN2792220
Sowa, Xie, Xu, Sessa: Serine 23 and 36 phosphorylation of caveolin-2 is differentially regulated by targeting to lipid raft/caveolae and in mitotic endothelial cells. in Biochemistry 2008
Show all 2 Pubmed References
High CAV2 expression is associated with lung cancer.
A-type lamin (show LMNA Antibodies)-dependent Caveolin-2 homo-oligomerization in the inner nuclear membrane microdomain is a precondition for pY19-Caveolin-2-mediated insulin (show INS Antibodies)-response epigenetic activation at the nuclear periphery.
CAV-1 (show CAV1 Antibodies) and -2 have roles in progression of prostate neoplasms
Caveolin-2 expression is necessary for the control of E2-dependent cellular proliferation of MCF-7 cells.
variant in CAV2 is associated with increased age-of-onset of P. aeruginosa airway infection in cystic fibrosis (show S100A8 Antibodies) cohort.
The minor allele G of rs17588172 in the CAV1 (show CAV1 Antibodies)-CAV2 locus is associated with decreased expression of CAV1 (show CAV1 Antibodies) and CAV2 in some tissues, marginally with intraocular pressure elevation, and consequently with increased susceptibility to high-tension glaucoma.
Results present initial characterization of key proteins Cav2 and CFL1 (show VPS72 Antibodies) as cellular factors that colocalize with M in viral inclusions and filaments and ZNF502 (show ZNF502 Antibodies) protein which appears to interact with RSV M in the nucleus.
The implication of the caveolin genes, CAV1 (show CAV1 Antibodies)/CAV2, as a common genetic factor influencing both IOP variations and POAG may provide new insights of the underlying mechanism leading to glaucoma and glaucomatous visual field loss.
CAV1 (show CAV1 Antibodies)/CAV2 SNPs were associated significantly with primary open-angle glaucoma overall, particularly among women.
Our findings did not correspond with previous positive results, suggesting that CAV1 (show CAV1 Antibodies)-CAV2 variants studied in the present study are not important risk factors for Normal Tension Glaucoma.
While structural and functional properties of resistance networks are well maintained in the gluteus muscle of Cav2(-/-) mice, diminished rapid onset vasodilation with greater force production reveals novel physiological roles for Cav2 in skeletal muscle.
We concluded that caveolin-2 is most probably involved in regulation of pro-inflammatory responses of BMDMs, triggered via activation of ERK1/2.
Cav-2 expressed in tumor microenvironment may potentially become a novel target for cancer therapy
In contrast to wild-type-Cav-2, retroviral re-expression of Y19/27F-Cav-2 in Cav-2 knockout endothelial cells did not affect anti-proliferative effect of TGF-beta (show TGFB1 Antibodies) compared to empty vector.
Data show that the balance between caveolin-1 (show CAV1 Antibodies) and caveolin-2 is important for iNOS (show NOS2 Antibodies) expression and ultimately for sepsis outcome.
The negative regulation of transforming growth factor-beta1 signaling and function by caveolin 2 is independent of caveolin 1 (show CAV1 Antibodies) expression levels and is not because of changing targeting of caveolin 1 (show CAV1 Antibodies) protein to plasma membrane lipid raft/caveolar domains.
Data suggest that Cav-2 negatively regulates lung endothelial cell proliferation and cell cycle progression.
Data show that amino acids K47-K57 of Cav-1 (show CAV1 Antibodies) are a highly conserved sequence in Cav-1 (show CAV1 Antibodies) and Cav-3 (show CAV3 Antibodies) proteins, and that expression of either K47-K57 deletion Cav-1 (show CAV1 Antibodies) mutant or wild-type Cav-2 that lacks this sequence exhibits a non-polarized distribution pattern.
Caveolin-2-deficient mice show evidence of severe pulmonary dysfunction without disruption of caveolae
Splice variant of mouse caveolin-2 mRNA, encoding an isoform lacking the C-terminal domain, localized to the endoplasmic reticulum, while the authentic caveolin-2 was distributed to the Golgi and the plasma membrane along with caveolin-1 (show CAV1 Antibodies).
The interaction of caveolin-2 with caveolin-1 (show CAV1 Antibodies) could play an important role in caveolae biogenesis and shear stimulated mechano-signal transduction.
miR (show MYLIP Antibodies)-29a mediated Caveolin 2 regulation, modulating the activation state of CDC42 (show CDC42 Antibodies), in intestinal Salmonella infection, is reported.
caveolin-2 is an integral component of the trafficking network in the intestinal cells of C. elegans
The protein encoded by this gene is a major component of the inner surface of caveolae, small invaginations of the plasma membrane, and is involved in essential cellular functions, including signal transduction, lipid metabolism, cellular growth control and apoptosis. This protein may function as a tumor suppressor. This gene and related family member (CAV1) are located next to each other on chromosome 7, and express colocalizing proteins that form a stable hetero-oligomeric complex. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. Additional isoforms resulting from the use of alternate in-frame translation initiation codons have also been described, and shown to have preferential localization in the cell (PMID:11238462).
caveolae protein, 20-kD
, caveolin 2 isoform a and b
, caveolin 2