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this is the first report of ECE-2 being an autoantigen in humans. We have identified ECE-2 as a specific autoantigen in APS1 with a restricted neuroendocrine distribution.
ECE-2 and ECE-1 levels are significantly reduced in post-mortem brain from dementia with Lewy body patients.
Te results of this study suggested taht genetic variations in MMEL1, ECE1, ECE2, AGER, PLG, PLAT, NR1H3, MMP3, LRP1, TTR, NR1H2, and MMP9 genes do not play major role among the Finnish AD patient cohort.
The PL405 assay is thus the first tool to study ECE-2 inhibition using high throughput screening or for ex vivo ECE-2 quantification.
Data show that CD133 and ECE expressions are associated with lymphoid metastasis and prognosis of NSCLC, and their overexpression often suggests unfavorable prognosis of NSCLC.
The most significantly downregulated gene in this data set was the endothelin converting enzyme 2 (ECE2), implicated in amyloid beta clearance.
An intact SAM-dependent methyltransferase fold is encoded by the human endothelin-converting enzyme-2 gene
Abeta accumulation in Alzheimer's disease is unlikely to be caused by ECE-2 deficiency. However, ECE-2 expression is up-regulated
It is a amyloid beta degrading enzyme and is expressed by distinct populations of GABAergic interneurons in hippocampus and neocortex.
These results suggest that ECE2, by selectively processing endogenous opioid peptides in the endocytic compartment, plays a role in modulating opioid receptor activity
a role for differential modulation of opioid receptor signaling by post-endocytic processing of peptide agonists by ECE2.
ECE-2 has a role in the non-classical processing of spinal cord peptides and morphine responses, including the cleavage of a number of neuropeptides at non-classical sites in vitro.
deficits in learning and memory in ECE2 knockout mice may provide unique insights into processes that may contribute to this disease and possible other disorders of cognition
novel four subisoforms of ECE-2 that differ in their N-terminal cytoplasmic tails
ECE2 has a role in limiting Abeta accumulation in the mouse brain
Data suggest that, in Fallopian tubes, endothelins (EDN1, EDN2, EDN3) and EDN-converting enzymes (ECE1, ECE2) are expressed in epithelial cells; EDN receptors (EDNRA, EDNRB) are present in smooth-muscle. Expression of EDN1, EDN2, and ECE2 is highest on day of ovulation. EDN/ENDR signaling appears to participate Fallopian tube function. These studies were conducted in Holstein cows.
Endothelin-converting enzymes, such as ECE2 (EC 220.127.116.11), are type II metalloproteases that generate functionally pleiotropic members of the endothelin vasoactive peptide family (Lorenzo et al., 2001
endothelin converting enzyme 2
, endothelin-converting enzyme 2
, endothelin-converting enzyme 2 isoform 2a-1
, endothelin-converting enzyme 2 isoform 2a-2
, endothelin-converting enzyme 2 isoform 2b-1
, endothelin-converting enzyme 2 isoform 2b-2