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Our results suggest that common ethnic-specific variation in GPR158 may influence energy expenditure (EE) in Pima Indians. rs11014566 nominally associated with measures of EE and adiposity, where the G allele associated with lower 24-h EE, lower Resting Metabolic Rate, higher BMI, and higher percent body fat. But, the association of rs11014566 with BMI did not directionally replicate when assessed in other ethnic groups.
expression and functional role of orphan receptor GPR158 in prostate cancer growth and progression
Mutation of the NLS abrogates GPR158-mediated enhancement of cell proliferation.
MiR-449a has a target dependent effect, inhibiting cell growth and migration by downregulation of CCND1 and suppressing neural phenotypes by inhibition of G protein coupled-receptor (GPR) 158.
mediates osteocalcin regulation of cognition
GPR158 is an essential regulator of RGS7 in the native nervous system with a critical role in controlling its expression, membrane localization, and catalytic activity
GPR158/179 recruited RGS complexes to the plasma membrane and augmented their ability to regulate GPCR signaling
probable G-protein coupled receptor 158