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Human Polyclonal PPP1R9B Primary Antibody for ELISA, WB - ABIN566586
Sagara, Kawasaki, Iemura, Natsume, Takai, Akiyama: Asef2 and Neurabin2 cooperatively regulate actin cytoskeletal organization and are involved in HGF-induced cell migration. in Oncogene 2009
Study determined that spinophilin binding to neurofilament medium required overexpression of the catalytic subunit of protein kinase A and was decreased by cyclin-dependent protein kinase 5 (show CDK5 Antibodies).
Clinical onset of AD is marked by the loss of PreC spinophilin-ir dendritic spines that is related to Abeta (show APP Antibodies) pathology and may contribute to cognitive symptoms early in the disease.
The increased cancer stem cells-like properties induced by the downregulation of Spn (show SPN Antibodies) might account for the increased malignant phenotype observed in Spn (show SPN Antibodies)-null breast tumors.
homo-oligomerization of neurabin is required for stabilizing RGS4 (show RGS4 Antibodies) on the plasma membrane to attenuate A1R (show ADORA1 Antibodies) signaling
Data identify Spn (show SPN Antibodies) as a critical adhesion and signaling protein that is essential for modulating glioblastoma cell invasion in the brain microenvironment. Spn (show SPN Antibodies) suppresses brain tumor cell invasion, in part, via control of Rac1 (show RAC1 Antibodies) GTPase (show RACGAP1 Antibodies) activities and invadopodia disassembly. Its C-terminus binds directly to the beta 8 integrin cytoplasmic tail.
results indicate that spinophilin plays an important role in regulating the activity of Group I mGluRs as well as their influence on synaptic activity.
Low spinophilin expression enhances aggressive biological behavior of breast cancer.
Colorectal carcinoma expression of spinophilin expression determines cellular growth, cancer stemness and 5-flourouracil resistance.
spinophilin might play a previously unrecognized role in the pathogenesis of head and neck squamous cell carcinoma
Spn (show SPN Antibodies) downregulation contributes to a more aggressive biologic behavior, induces chemoresistance, and is associated with a poorer survival in patients with advanced stages of colorectal carcinoma.
two homologs neurabin and spinophilin play important yet distinct roles in the regulation of anxiety- and depression-like behaviors in an age-dependent manner.
COPS5 (show COPS5 Antibodies) overexpression reduced spinophilin in both the cortex (19%, p < 0.05) and the hippocampus (20%, p < 0.05), leading to significant deficits in learning and memory skills
RanBP9 overexpression in transgenic mice led to striking reduction in the levels of spinophilin.
Canonical betaAR-mediated signaling coupled to PKA activation results in phosphorylation of spinophilin, disrupting its interaction with alpha2AARs and accelerating alpha2AAR (show ADRA2A Antibodies) endocytic responses.
Findings support the concept that the inhibitory effects of SPL (show SGPL1 Antibodies) on M3R (show CHRM3 Antibodies) activity are mediated by RGS4 (show RGS4 Antibodies).
changes in spinophilin/CaMKII (show CAMK2G Antibodies) interactomes may contribute to changes in striatal dendritic spine density, morphology, and function during normal postnatal maturation and aging.
these data suggest that spinophilin is an upstream regulator required for normal growth and excitation-contraction coupling, but is dispensable for beta-adrenergic stimulation of adult cardiomyocytes.
Findings suggest that spinophilin restrains Angiotensin II-mediated sympathetic nervous system activation and is an unrecognized molecule with regard to central blood pressure control
We suggest that Spn (show SPN Antibodies) may be the tumor suppressor gene located at 17q21.33 acting through Rb regulation.
Spinophilin is a regulatory subunit of protein phosphatase-1 catalytic subunit (PP1\; see MIM 176875) and is highly enriched in dendritic spines, specialized protrusions from dendritic shafts that receive most of the excitatory input in the central nervous system (Allen et al., 1997
, neurabin 2
, neural tissue-specific F-actin-binding protein II
, nuerabin 2
, neurabin II
, protein phosphatase 1, regulatory (inhibitor) subunit 9B
, protein phosphatase 1, regulatory subunit 9B, spinophilin