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p53 (show TP53 Proteins) may modulate immune responses through suppression of RGS13 transcription in mast cells and B cells
RGS13 turnover was significantly reduced in cells stimulated with cAMP, which was reversed by expression of the PKA-specific inhibitory peptide PKI.
Functional characterization of the G protein regulator RGS13
Down-Regulation of regulator of G-protein signalling 13 is associated with mantle cell lymphoma
RGS1 and RGS13 act together to regulate chemokine receptor signaling in human germinal center B lymphocytes and contribute significantly to the rapid desensitization of the signaling pathway.
RGS13 overexpression inhibited CXCL12 (show CXCL12 Proteins)-evoked Ca(2 (show CA2 Proteins)+) mobilization, Akt (show AKT1 Proteins) phosphorylation and chemotaxis.
Rgs13 is strongly expressed in the germinal center regions of spleen, Peyer's patches, and thymic medulla, interacts with Gialpha and Gqalpha, and strongly inhibits both CXCL12 (show CXCL12 Proteins)- and CXCL13 (show CXCL13 Proteins)-induced signaling.
The protein encoded by this gene is a member of the regulator of G protein signaling (RGS) family. RGS family members share similarity with S. cerevisiae SST2 and C. elegans egl-10 proteins, which contain a characteristic conserved RGS domain. RGS proteins accelerate GTPase activity of G protein alpha-subunits, thereby driving G protein into their inactive GDP-bound form, thus negatively regulating G protein signaling. RGS proteins have been implicated in the fine tuning of a variety of cellular events in response to G protein-coupled receptor activation. The biological function of this gene, however, is unknown. Two transcript variants encoding the same isoform exist.
regulator of G-protein signalling 13