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zebrafish bmp5 is expressed in neural crest progenitor cells and it activates the Smad (show SMAD1 Proteins) and Erk (show MAPK1 Proteins) signaling pathways to regulate cell survival and proliferation, respectively.
results demonstrate that bone morphogenetic protein 5 is differentially expressed in the bovine oviductal isthmus during the estrous cycle showing that it could be a regulator of the reproductive events that occur in the bovine oviductal environment
findings suggested that BMP5 might be a potential prognostic biomarker or therapeutic target for patients with NSCLC
Our results showed that ASPN rs13301537 T to C change and variant C genotype may contribute to knee OA risk in a Chinese Han population.
Data indicate significant association between the bone morphogenetic protein 5 (BMP5) microsatellite and knee osteoarthritis (OA) in women, but not in men.
BMP5, is elevated in the stenotic colon segment of Hirschsprung disease patients, and BMP5 signaling may play a pivotal role in disease development.
BMP5 and BMP7 (show BMP7 Proteins), involved in cardiomyocyte differentiation defect
CASP3 (show CASP3 Proteins) rs4862396, BMP5 rs3734444 and IRS2 (show IRS2 Proteins) rs7986346 may affect the survival in patients after androgen-deprivation therapy for prostate cancer
BMP-5 is expressed in the tubuli of adult kidneys. Its decreased expression in nephrosclerosis along with its regenerative capabilities in HK-2 (show HK2 Proteins) cells may point to a protective role in hypertensive nephrosclerosis.
Taken together, BMP4 (show BMP4 Proteins) and BMP5 simultaneously inhibit the growth and promote migration and invasion of the same pancreatic cells and thus exhibit a biphasic role with both detrimental and beneficial functions in pancreatic cancer progression
Variability in gene expression of BMP5 may be an important contributor to osteoarthritis genetic susceptibility
The expression signals of BMP-5 mRNA in malignant schwannoma were relatively lower than in benign lesions
Data conclude that BMP-5 has stage-specific role to play during MC3T3E1 osteoblast differentiation in part by autocrine p38 (show CRK Proteins)/Runx2 (show RUNX2 Proteins)/COLIA1 (show COL1A1 Proteins) signaling.
Bmp5 gene thus contains an "injury response" control region that is distinct from embryonic enhancers, and that is activated by multiple types of injury in adult animals
Early endothelial outgrowth cells act protective in diabetic nephropathy, and such effects are significantly stimulated by BMP-5
BMP-5 acts as a potent endothelial outgrowth cells agonist in murine AKI in the short and mid to long term
Bone morphogenetic protein 5 regulates the number of keratinocyte stem cells from the skin of mice.
Data indicate that locus coeruleus development requires either Bmp5 or Bmp7 (show BMP7 Proteins), and one is able to compensate for the loss of the other.
BMP5 is required not only for skeletal patterning during embryonic development, but also for bone response and remodeling to mechanical stimulation at specific anatomic sites in the skeleton
Bmp5 is expressed in many skeletal precursors and different enhancers control expression in individual bones.
This gene encodes a member of the bone morphogenetic protein family which is part of the transforming growth factor-beta superfamily. The superfamily includes large families of growth and differentiation factors. Bone morphogenetic proteins were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. These proteins are synthesized as prepropeptides, cleaved, and then processed into dimeric proteins. This protein may act as an important signaling molecule within the trabecular meshwork and optic nerve head, and may play a potential role in glaucoma pathogenesis. This gene is differentially regulated during the formation of various tumors.
bone morphogenetic protein 5
, bone morphogenetic protein 5-like
, bone morphogenenic protein-5
, short ear