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anti-Human BMP6 Antibodies:
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Human Polyclonal BMP6 Primary Antibody for IHC (p), WB - ABIN388456
Olavesen, Bentley, Mason, Stephens, Ragoussis: Fine mapping of 39 ESTs on human chromosome 6p23-p25. in Genomics 1998
Show all 5 Pubmed References
Synergistic effects of BMP-2 (show BMP2 Antibodies), BMP-6 or BMP-7 (show BMP7 Antibodies) with human plasma fibronectin (show FN1 Antibodies) onto hydroxyapatite coatings.
Study demonstrated that the mesenchymal epithelial/myoepithelial potential of transdifferentiation of the luminal cells that make up the proliferative units is certified by the immunohistochemical expression of some BMP6 purely mesenchymal protein cells.
both bone morphogenetic protein 2 (BMP2 (show BMP2 Antibodies)) and BMP6 are proangiogenic in vitro and ex vivo and that the BMP type I receptors, activin receptor-like kinase 3 (ALK3 (show BMPR1A Antibodies)) and ALK2 (show ACRV1 Antibodies), play crucial and distinct roles in this process.
Plasma BMP6 was significantly increased in chronic heart failure patients.
Our results independently add further evidence to the role of BMP6 mutations as likely contributing factors to late-onset moderate IO unrelated to mutations in the established five HH genes.
Further investigation on clinical ESCC samples and non-tumorous adjacent tissue found that tumors with triple-positive BMP6, ALK2 (show ACRV1 Antibodies) and BMPRII (show BMPR2 Antibodies) had deeper growth than tumors with only BMP6 expression
study shows that patients with CRA (show MTMR11 Antibodies) had high expression of BMP6 and hepcidin (show HAMP Antibodies) and low expression of s-HJV (show HFE2 Antibodies). BMP6 was found to be negatively correlated with s-HJV (show HFE2 Antibodies); both regulate hepcidin (show HAMP Antibodies) expression and play important roles in the development of anemia.
the combined delivery of VEGF (show VEGFA Antibodies) and BMP-6 to the bone defect significantly enhanced bone repair through the enhancement of angiogenesis and the differentiation of endogenously recruited MSCs into the bone repair site.
BMP-6 upregulates somatostatin receptor actions, leading to reduction of GnRH-induced secretion of luteinizing hormone.
These observations suggest a novel role of BMP-6 in the inhibition of breast cancer metastasis by regulating secretion of MMPs(MMP-1 (show MMP1 Antibodies)) in the tumor microenvironment.
Report temporal regulation of BMP6 mRNA expression in the oocyte, granulosa and theca cells of developing preovulatory follicles in the pig.
study revealed that only BMP-6 was able to induce bone formation at the used dose and that the addition of IGF-1 (show IGF1 Antibodies) contributed to an increase of the mineralization in the implants. Hence, the combination of BMP-6 with IGF-1 (show IGF1 Antibodies) might be a better alternative than BMP-2 (show BMP2 Antibodies) for orthopedic surgery or bone tissue engineering approaches.
These data suggest that, in Hjv (show HFE2 Antibodies)(-/-) females, Bmp6 can provide a signal adequate to maintain hepcidin (show HAMP Antibodies) to a level sufficient to avoid extrahepatic iron loading.
The data demonstrate that endothelial cells are the predominant source of BMP6 in the liver and support a model in which endothelial cells BMP6 has paracrine actions on hepatocyte hemojuvelin (show HFE2 Antibodies) to regulate hepcidin (show HAMP Antibodies) transcription and maintain systemic iron homeostasis.
In summary, our data suggest that in obstructive nephropathy atrophy increases and fibrosis decreases with age and that this relates to increased BMP signaling, most likely due to higher BMP6 and lower CTGF (show CTGF Antibodies) expression.
Western blot analysis demonstrated that following BMP2 (show BMP2 Antibodies) and BMP7 (show BMP7 Antibodies) cotransfection of MC3T3E1 cells, the protein expression levels of BMP2 (show BMP2 Antibodies), BMP4 (show BMP4 Antibodies), BMP6, BMP7 (show BMP7 Antibodies), BMP9 (show GDF2 Antibodies) and Wnt3a (show WNT3A Antibodies) were increased compared with control cells
In Bmp6-/- mice, iron activated endogenous compensatory mechanisms of other BMPs that were not sufficient for preventing hemochromatosis (show HFE Antibodies) and bone loss.
BMP6 expression levels may have potential as predictive markers for the progression of non-alcoholic liver disease.
The expression of BMP6 in periodontal ligaments may contribute to interaction between the tooth and bone during the eruption and anchoring process.
BMP-6 secreted by prostate cancer cells induces IL-6 (show IL6 Antibodies) expression in macrophages; IL-6 (show IL6 Antibodies), in turn, stimulates the neuroendocrine differentiation of prostate cancer cells.
these data highlight a therapeutically innovative role for BMP6 by providing a means to enhance the amount of myogenic lineage derived brown fat.
High BMP6 expression is associated with cystic ovarian disease.
BMP6 and oxidized low-density lipoprotein independently and synergistically induced osteogenic differentiation and mineralization in vascular endothelial cells.
BMP-6 mRNA is increased during transition from primordial to primary/secondary follicles in the goat ovaries.
The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. Many BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. Based on its expression early in embryogenesis, the BMP encoded by this gene has a proposed role in early development. In addition, the fact that this BMP is closely related to BMP5 and BMP7 has lead to speculation of possible bone inductive activity.
bone morphogenetic protein 6
, VG-1-related protein
, Vg1-related sequence
, vegetal related growth factor (TGFB-related)
, vegetal-related (TGFB related) cytokine
, bone morphogenic protein 6