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Human Monoclonal KDM1A Primary Antibody for ChIP, ELISA - ABIN151289
Lim, Janzer, Becker, Zimmer, Schüle, Buettner, Kirfel: Lysine-specific demethylase 1 (LSD1) is highly expressed in ER-negative breast cancers and a biomarker predicting aggressive biology. in Carcinogenesis 2010
Show all 10 Pubmed References
Human Polyclonal KDM1A Primary Antibody for ELISA, WB - ABIN1002761
Shi, Lan, Matson, Mulligan, Whetstine, Cole, Casero, Shi: Histone demethylation mediated by the nuclear amine oxidase homolog LSD1. in Cell 2004
Show all 4 Pubmed References
Human Polyclonal KDM1A Primary Antibody for IHC, ELISA - ABIN1002762
Kouzarides: Histone methylation in transcriptional control. in Current opinion in genetics & development 2002
Show all 4 Pubmed References
Human Monoclonal KDM1A Primary Antibody for IHC, ELISA - ABIN969264
Shi, Matson, Lan, Iwase, Baba, Shi: Regulation of LSD1 histone demethylase activity by its associated factors. in Molecular cell 2005
Show all 2 Pubmed References
Human Polyclonal KDM1A Primary Antibody for IF, IHC (p) - ABIN388023
Forneris, Binda, Vanoni, Mattevi, Battaglioli: Histone demethylation catalysed by LSD1 is a flavin-dependent oxidative process. in FEBS letters 2005
Show all 8 Pubmed References
Human Monoclonal KDM1A Primary Antibody for IF, IHC (p) - ABIN564989
Chen, Obara, Ishida, Suzuki, Yoshizato: Characterization of histone lysine-specific demethylase in relation to thyroid hormone-regulated anuran metamorphosis. in Development, growth & differentiation 2007
Human Polyclonal KDM1A Primary Antibody for ICC, IF - ABIN151968
Su, Ying, Chiu, Lin, Chen, Lin: Involvement of histone demethylase LSD1 in Blimp-1-mediated gene repression during plasma cell differentiation. in Molecular and cellular biology 2009
Human Polyclonal KDM1A Primary Antibody for ChIP, WB - ABIN5563974
Holdt, Hoffmann, Sass, Langenberger, Scholz, Krohn, Finstermeier, Stahringer, Wilfert, Beutner, Gielen, Schuler, Gäbel, Bergert, Bechmann, Stadler, Thiery, Teupser: Alu elements in ANRIL non-coding RNA at chromosome 9p21 modulate atherogenic cell functions through trans-regulation of gene networks. in PLoS genetics 2013
Human Monoclonal KDM1A Primary Antibody for IHC, ELISA - ABIN966497
Metzger, Wissmann, Yin, Müller, Schneider, Peters, Günther, Buettner, Schüle: LSD1 demethylates repressive histone marks to promote androgen-receptor-dependent transcription. in Nature 2005
LSD1 inhibition may serve as a promising epigenetic adjuvant therapy to subvert its pleiotropic roles in breast cancer progression and treatment resistance.
Results show that KDM1A is upregulated in the gastric cancer (GC) cells and tissues. Its expression is negatively modulated by mir329 which directly targets its 3'utr (show UTS2R Antibodies).
FOXP4 (show FOXP4 Antibodies)-AS1 (show PTGDR Antibodies) is overexpressed in osteosarcoma (OS), and is the independent risk factor in OS prognosis. Upregulated FOXP4 (show FOXP4 Antibodies)-AS1 (show PTGDR Antibodies) promotes the proliferation, migration and cell cycle, but inhibits apoptosis of OS cells. Furthermore, FOXP4 (show FOXP4 Antibodies)-AS1 (show PTGDR Antibodies) participates in the development and progression of OS by downregulating LATS1 via binding to LSD1 and EZH2 (show EZH2 Antibodies).
Enhancer of Zeste Homolog 2 (EZH2 (show EZH2 Antibodies)), SET domain, bifurcated 1 protein (SETDB1 (show SETDB1 Antibodies)), lysine-specific histone demethylase 1 (LSD1), histone H3 (show HIST3H3 Antibodies) methylation (H3K9me3 and H3K27me3) expression are altered in colorectal cancer (CRC (show CALR Antibodies)) and may play a role in colorectal carcinogenesis.
the crystal structure of LSD1 in complex with the inhibitor 4-[5-(Piperidin-4-ylmethoxy)-2-(p-tolyl)pyridin-3-yl]benzonitrile at 2.96 A, is reported.
This study showed that tetrahydrofolate stably binds to the LSD1/CoREST (show RCOR1 Antibodies) complex, in its open conformation, at its entrance.
Study reveals LSD1 as a molecular rheostat selectively regulating H3K9 demethylation at cell cycle gene loci, thereby representing a key player in oncogenesis and a viable target for cancer therapy.
KDM1A is a unique epigenetic modifier with the ability to maintain interactions with a variety of different protein complexes, noncoding RNAs, microRNAs, and transcription factors. The functional significance of KDM1A is maintained by its interactions at multiple sites in the genome, particularly its binding to promoters and enhancers. [review]
our findings identified LSD1 as a novel negative regulator of autophagy through the mTOR (show FRAP1 Antibodies) signaling pathway in ovarian cancer HO8910 cells and indicated that LSD1 may function as a driving factor of ovarian cancer progression via deregulating autophagy.
a small-molecule LSD1 inhibitor-SP-2509-blocks important demethylase (show MBD2 Antibodies)-independent functions and suppresses castration-resistant prostate cancer cell viability demonstrates the potential of LSD1 inhibition in this disease.
CACUL1 reciprocally regulates SIRT1 (show SIRT1 Antibodies) and LSD1 to repress PPARgamma (show PPARG Antibodies) and inhibit adipogenesis.
These results indicate that LSD1 activators or miRNA antagonists could serve as a therapeutic approach for life-threatening septic shock characterized by dysfunction of hematopoietic stem cells.
MiR (show MLXIP Antibodies)-137-3p was upregulated in Bv-injured DRGNs. MiR (show MLXIP Antibodies)-137-3p downregulation rescued Bv-induced DRGN apoptosis and neurite retraction. MiR (show MLXIP Antibodies)-137-3p and its downstream target LSD1 are inversely associated to regulate anesthetics-induced neurotoxicity in DRGN.
contrary to its role in enhancing DNA virus replication, LSD1 limits RNA virus replication by demethylating and activating IFITM3 (show IFITM3 Antibodies) which is a host restriction factor for many RNA viruses
Data (including data from studies in transgenic/knockout mice) suggest that Kdm1a-mediated attenuation of Srebf1 (show TOM1L2 Antibodies) transcriptional activities functions as underlying mechanism for suppression of de novo lipogenesis by oxidative stress in white adipose tissue. [Kdm1a = lysine (K)-specific demethylase-1A; Srebf1 (show TOM1L2 Antibodies) = sterol-regulatory element-binding transcription factor-1 (show SREBF1 Antibodies)]
This study demonstrated that LSD1 expression during Olfactory Epithelium neuronal maturation.
LSD1 having a role in silencing additional odorant receptor (OR) alleles, as opposed to being required for the activation of OR alleles, within theolfactory-placode-derived cell line cellular context
results identify the LSD1/NuRD complex as a previously unrecognized modulator for Pax2-mediated neuronal differentiation in the inner ear
Lsd1 regulates skeletal muscle regeneration and directs the fate of satellite cells into myocytes while preventing brown adipocyte differentiation of satellite cells via repressing expression of the novel pro-adipogenic transcription factor Glis1 (show GLIS1 Antibodies).
LSD1 is continuously required to prevent neurodegeneration. Loss of LSD1 in adult mice leads to paralysis and neurodegeneration in the hippocampus and cortex.
LSD1 plays a critical role in hair cell regeneration and might represent a novel biomarker and potential therapeutic approach for the treatment of hearing loss.
results suggest that the LSD1-dependent shutdown of Etv2 (show ETV2 Antibodies) gene expression may be a significant event required for hemangioblasts to initiate hematopoietic differentiation
Results indicate that LSD1 demethylase (show MBD2 Antibodies) activity is required for neuromast development in zebrafish larvae.
LSD1 gene has two transcripts and is expressed in various tissues and relatively higher in ovary, kidney, and spleen.
This gene encodes a nuclear protein containing a SWIRM domain, a FAD-binding motif, and an amine oxidase domain. This protein is a component of several histone deacetylase complexes, though it silences genes by functioning as a histone demethylase. Alternative splicing results in multiple transcript variants.
BRAF35-HDAC complex protein BHC110
, FAD-binding protein BRAF35-HDAC complex, 110 kDa subunit
, amine oxidase (flavin containing) domain 2
, flavin-containing amine oxidase domain-containing protein 2
, lysine (K)-specific demethylase 1
, lysine-specific histone demethylase 1
, lysine-specific histone demethylase 1A
, neuroprotective protein 3
, lysine (K)-specific demethylase 1A