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Human Monoclonal KDM1A Primary Antibody for ChIP, ELISA - ABIN151289
Lim, Janzer, Becker, Zimmer, Schüle, Buettner, Kirfel: Lysine-specific demethylase 1 (LSD1) is highly expressed in ER-negative breast cancers and a biomarker predicting aggressive biology. in Carcinogenesis 2010
Show all 8 Pubmed References
Human Polyclonal KDM1A Primary Antibody for ELISA, WB - ABIN1002761
Shi, Lan, Matson, Mulligan, Whetstine, Cole, Casero, Shi: Histone demethylation mediated by the nuclear amine oxidase homolog LSD1. in Cell 2004
Show all 4 Pubmed References
Human Polyclonal KDM1A Primary Antibody for IHC, ELISA - ABIN1002762
Kouzarides: Histone methylation in transcriptional control. in Current opinion in genetics & development 2002
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Human Monoclonal KDM1A Primary Antibody for IHC, ELISA - ABIN969264
Shi, Matson, Lan, Iwase, Baba, Shi: Regulation of LSD1 histone demethylase activity by its associated factors. in Molecular cell 2005
Show all 2 Pubmed References
Human Polyclonal KDM1A Primary Antibody for IF, IHC (p) - ABIN388023
Forneris, Binda, Vanoni, Mattevi, Battaglioli: Histone demethylation catalysed by LSD1 is a flavin-dependent oxidative process. in FEBS letters 2005
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Human Monoclonal KDM1A Primary Antibody for IF, IHC (p) - ABIN564989
Chen, Obara, Ishida, Suzuki, Yoshizato: Characterization of histone lysine-specific demethylase in relation to thyroid hormone-regulated anuran metamorphosis. in Development, growth & differentiation 2007
Human Monoclonal KDM1A Primary Antibody for IHC, ELISA - ABIN966497
Metzger, Wissmann, Yin, Müller, Schneider, Peters, Günther, Buettner, Schüle: LSD1 demethylates repressive histone marks to promote androgen-receptor-dependent transcription. in Nature 2005
Human Polyclonal KDM1A Primary Antibody for ChIP, WB - ABIN5563974
Holdt, Hoffmann, Sass, Langenberger, Scholz, Krohn, Finstermeier, Stahringer, Wilfert, Beutner, Gielen, Schuler, Gäbel, Bergert, Bechmann, Stadler, Thiery, Teupser: Alu elements in ANRIL non-coding RNA at chromosome 9p21 modulate atherogenic cell functions through trans-regulation of gene networks. in PLoS genetics 2013
Human Polyclonal KDM1A Primary Antibody for ICC, IF - ABIN151968
Su, Ying, Chiu, Lin, Chen, Lin: Involvement of histone demethylase LSD1 in Blimp-1-mediated gene repression during plasma cell differentiation. in Molecular and cellular biology 2009
LSD1 inhibition with HCI-2509 decreases the c-MYC (show MYC Antibodies) level in poorly differentiated prostate cancer cell lines.
Such a relatively simple strategy uncovered two new classes of LSD1 inhibitors , which reveal unexpected binding modes at the same protein surface, establishing specific and common contacts, and highlight novel routes for the development of compounds targeting epigenetic processes.
we show that KDM1A promotes cancer metastasis in non-small cell lung cancer cells by repressing TIMP3 (tissue inhibitor of metalloproteinase 3 (show TIMP3 Antibodies)) expression.
Results show that LSD1 expression was upregulated in breast carcinoma and, induced EMT (show ITK Antibodies) in breast cancer cells through demethylation of H3K4me at the E-cadherin (show CDH1 Antibodies) promoter. Its phosphorylation at Ser112 is crucial for these functions.
LSD1 directly associates with the promoter of the HEYL (show HEYL Antibodies) gene.
LSD1 controls autophagy in neuroblastoma (show ARHGEF16 Antibodies) cells through SESN2 (show SESN2 Antibodies) transcription regulation.
Mechanistic investigations showed that LINC01133 could interact with EZH2 (show EZH2 Antibodies), LSD1 and recruit them to KLF2 (show KLF2 Antibodies), P21 (show CDKN1A Antibodies) or E-cadherin (show CDH1 Antibodies) promoter regions to repress their transcription.
estrogen induced TFPI-2 (show TFPI2 Antibodies) expression in MCF7 cells is mediated by ERalpha (show ESR1 Antibodies) and also by the action of LSD1.
CENPE (show CENPE Antibodies) was regulated by the co-binding of LSD1 and AR to its promoter, which was associated with loss of RB1 (show RB1 Antibodies) in CRPC.
RBPJ (show RBPJ Antibodies) interacts with L3MBTL3 (show L3MBTL3 Antibodies) to promote repression of Notch (show NOTCH1 Antibodies) signaling via histone demethylase (show MBD2 Antibodies) KDM1A.
LSD1 consolidates into a single dominant compartment at the edges of chromocenters within nuclei of early post-mitotic cells of the mouse olfactory epithelium. LSD1 complexes with CoREST (show Rcor2 Antibodies) in early G1 of an immortalized olfactory cell line.
LSD1 is required for the timely expression of MyoD (show MYOD1 Antibodies) in limb buds.
Lsd1 is a key regulator of gene expression and metabolic function in brown adipose tissue.
The Demethylase (show MBD2 Antibodies) Activity of LSD1 Is Required for Brown Adipogenesis.
through interaction with Zfp516 (show ZNF516 Antibodies), LSD1 is recruited to UCP1 (show UCP1 Antibodies) and other brown adipose tissue-enriched genes.
Study propose that KDM1A is a key regulator of spermatogenesis and germ cell maintenance in the mouse.
This study demonstrates that the FGF19 (show FGF19 Antibodies)-SHP (show LAMC1 Antibodies)-LSD1 axis maintains homeostasis by suppressing unnecessary autophagic breakdown of cellular components, including lipids, under nutrient-rich postprandial conditions.
This analysis identified that LSD1 is the only lysine demethylase (show MBD2 Antibodies) required for myogenic differentiation and that KDM3B (show KDM3B Antibodies), KDM6A (show KDM6A Antibodies), and KDM8 (show JMJD5 Antibodies) are the candidate lysine demethylases required for osteoblast differentiation.
Class I KDACs facilitate Dex-induced transcriptional repression by suppressing LSD1 complex activity at selected target gene promoters
The study describes an interaction network of STAT5a (show STAT5A Antibodies)/LSD1/HDAC3 (show HDAC3 Antibodies) and a dual function of LSD1/HDAC3 (show HDAC3 Antibodies) on STAT5a (show STAT5A Antibodies)-dependent transcription, defined by protein-protein interactions, genomic binding localization/affinity and motifs.
LSD1 plays a critical role in hair cell regeneration and might represent a novel biomarker and potential therapeutic approach for the treatment of hearing loss.
results suggest that the LSD1-dependent shutdown of Etv2 (show ETV2 Antibodies) gene expression may be a significant event required for hemangioblasts to initiate hematopoietic differentiation
Results indicate that LSD1 demethylase (show MBD2 Antibodies) activity is required for neuromast development in zebrafish larvae.
LSD1 gene has two transcripts and is expressed in various tissues and relatively higher in ovary, kidney, and spleen.
LSD1, EDS1, and PAD4 (show PADI4 Antibodies) participate in the regulation of various molecular and physiological processes that influence Arabidopsis fitness.
AtSWP1 and AtCZS represent two main components of a co-repressor complex that fine tunes flowering and is unique to plants.
AtLSD1, similar to HsLSD1, has demethylase (show MBD2 Antibodies) activity toward mono- and dimethylated Lys4 but not dimethylated Lys9 and Lys27 of histone 3. [LSD1]
This gene encodes a nuclear protein containing a SWIRM domain, a FAD-binding motif, and an amine oxidase domain. This protein is a component of several histone deacetylase complexes, though it silences genes by functioning as a histone demethylase. Alternative splicing results in multiple transcript variants.
amine oxidase (flavin containing) domain 2
, lysine (K)-specific demethylase 1
, lysine (K)-specific demethylase 1A
, BRAF35-HDAC complex protein BHC110
, FAD-binding protein BRAF35-HDAC complex, 110 kDa subunit
, flavin-containing amine oxidase domain-containing protein 2
, lysine-specific histone demethylase 1
, lysine-specific histone demethylase 1A
, neuroprotective protein 3