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Human Monoclonal KDM1A Primary Antibody for ChIP, ELISA - ABIN151289
Lim, Janzer, Becker, Zimmer, Schüle, Buettner, Kirfel: Lysine-specific demethylase 1 (LSD1) is highly expressed in ER-negative breast cancers and a biomarker predicting aggressive biology. in Carcinogenesis 2010
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Human Polyclonal KDM1A Primary Antibody for ELISA, WB - ABIN1002761
Shi, Lan, Matson, Mulligan, Whetstine, Cole, Casero, Shi: Histone demethylation mediated by the nuclear amine oxidase homolog LSD1. in Cell 2004
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Human Polyclonal KDM1A Primary Antibody for IHC, ELISA - ABIN1002762
Kouzarides: Histone methylation in transcriptional control. in Current opinion in genetics & development 2002
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Human Polyclonal KDM1A Primary Antibody for IHC (p), WB - ABIN541521
Nakamura, Mori, Tada, Krajewski, Rozovskaia, Wassell, Dubois, Mazo, Croce, Canaani: ALL-1 is a histone methyltransferase that assembles a supercomplex of proteins involved in transcriptional regulation. in Molecular cell 2002
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Human Polyclonal KDM1A Primary Antibody for IHC (p), ELISA - ABIN542809
Hakimi, Dong, Lane, Speicher, Shiekhattar: A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes. in The Journal of biological chemistry 2003
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Human Polyclonal KDM1A Primary Antibody for IHC (p), ELISA - ABIN542808
Forneris, Binda, Vanoni, Mattevi, Battaglioli: Histone demethylation catalysed by LSD1 is a flavin-dependent oxidative process. in FEBS letters 2005
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Human Monoclonal KDM1A Primary Antibody for IHC (fro), IHC (p) - ABIN537073
Metzger, Wissmann, Yin, Müller, Schneider, Peters, Günther, Buettner, Schüle: LSD1 demethylates repressive histone marks to promote androgen-receptor-dependent transcription. in Nature 2005
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Human Monoclonal KDM1A Primary Antibody for IHC, ELISA - ABIN969264
Shi, Matson, Lan, Iwase, Baba, Shi: Regulation of LSD1 histone demethylase activity by its associated factors. in Molecular cell 2005
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Human Polyclonal KDM1A Primary Antibody for IF, IHC (p) - ABIN388023
Hakimi, Bochar, Chenoweth, Lane, Mandel, Shiekhattar: A core-BRAF35 complex containing histone deacetylase mediates repression of neuronal-specific genes. in Proceedings of the National Academy of Sciences of the United States of America 2002
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our data show that LSD1 confers lung adenocarcinoma cells with invasive and dedifferentiated attributes by modulating a non-canonical integrin beta3-KRAS signaling pathway.
The deacetylase selectivity of core CoREST complex (LHC) unexpectedly shows a marked preference for H3 acetyl-Lys9 versus acetyl-Lys14 in nucleosome substrates but this selectivity is lost with isolated acetyl-Lys H3 protein. LHC demethylase activity toward methyl-Lys4 in histone H3 is strongly inhibited by H3 Lys14 acetylation, and this appears to be an intrinsic property of the LSD1 subunit.
our results suggest that KDM1A hypomethylation is significantly associated with colorectal cancer
FOXD2-AS1 acted as a tumor inducer in GC partly through EphB3 inhibition by direct interaction with EZH2 and LSD1.
vitamin B2 induced activation of LSD1 may attenuate the proliferation inhibition, and anti-migration effects of apatinib in gastric cancer cells. These findings suggested that vitamin B supplementation may interfere with the efficacy of apatinib in patients with gastric cancer.
Using a combination of ROS specific dyes, monoamine oxidase inhibitor, LSD1 inhibitor, and LSD1 depletion by siRNA we have found that the oxidase and chromatin remodeling protein Lysine demethylase I (LSD1/KDM1A) generates detectable ROS as a byproduct of its chromatin remodeling activity during the initial DNA damage response.
Results reveal that CAF-induced expression of Notch3 is responsible for LSD1 activation in CSC, driving their self-renewal in HCC. These seminal findings illuminate a complex pathway in the tissue microenvironment of liver cancer, which is responsible for orchestrating the self-renewal of stem-like cancer cells.
The authors demonstrate that the SIX3/LSD1/NuRD(MTA3) complex inhibits carcinogenesis in breast cancer cells and suppresses metastasis in breast cancer.
Data suggest that, in human ovarian teratocarcinoma cell line, methylation-dependent proteolysis of SOX2 is controlled by LSD1 and PHF20L1 via regulation of SET7 activity; these data are consistent with previous studies in mouse primary stem cells. (SOX2 = SRY-box 2 transcription factor; LSD1 = lysine demethylase-1A; PHF20L1 = PHD finger protein 20 like-1; SET7 = histone-lysine N-methyltransferase SETD7)
the role of the LSD1 complex in the reactivation of HIV-1 transcription from latency
LSD1 and JMJD2C disable oncogenic Ras- or Braf-induced senescence by enabling the expression of E2F target genes
LSD1 inhibition may serve as a promising epigenetic adjuvant therapy to subvert its pleiotropic roles in breast cancer progression and treatment resistance.
Results show that KDM1A is upregulated in the gastric cancer (GC) cells and tissues. Its expression is negatively modulated by mir329 which directly targets its 3'utr.
FOXP4-AS1 is overexpressed in osteosarcoma (OS), and is the independent risk factor in OS prognosis. Upregulated FOXP4-AS1 promotes the proliferation, migration and cell cycle, but inhibits apoptosis of OS cells. Furthermore, FOXP4-AS1 participates in the development and progression of OS by downregulating LATS1 via binding to LSD1 and EZH2.
Enhancer of Zeste Homolog 2 (EZH2), SET domain, bifurcated 1 protein (SETDB1), lysine-specific histone demethylase 1 (LSD1), histone H3 methylation (H3K9me3 and H3K27me3) expression are altered in colorectal cancer (CRC) and may play a role in colorectal carcinogenesis.
the crystal structure of LSD1 in complex with the inhibitor 4-[5-(Piperidin-4-ylmethoxy)-2-(p-tolyl)pyridin-3-yl]benzonitrile at 2.96 A, is reported.
This study showed that tetrahydrofolate stably binds to the LSD1/CoREST complex, in its open conformation, at its entrance.
Study reveals LSD1 as a molecular rheostat selectively regulating H3K9 demethylation at cell cycle gene loci, thereby representing a key player in oncogenesis and a viable target for cancer therapy.
KDM1A is a unique epigenetic modifier with the ability to maintain interactions with a variety of different protein complexes, noncoding RNAs, microRNAs, and transcription factors. The functional significance of KDM1A is maintained by its interactions at multiple sites in the genome, particularly its binding to promoters and enhancers. [review]
our findings identified LSD1 as a novel negative regulator of autophagy through the mTOR signaling pathway in ovarian cancer HO8910 cells and indicated that LSD1 may function as a driving factor of ovarian cancer progression via deregulating autophagy.
this study shows that LSD1 is required for germinal center formation and BCL6-driven lymphomagenesis
diminished expression of PU.1 or genetic deletion of C/EBPalpha in MLL-AF9 cells generates resistance of these leukemias to LSD1 inhibition. These findings reveal that pharmacologic inhibition of LSD1 represents a unique path to overcome the differentiation block in AML for therapeutic benefit.
collaborative action between SRRM4 and FUBP1 is necessary for mini-exon splicing of the neurospecific LSD1+8a isoform.
identify Lsd1 inhibitors as promising therapeutic agents for Gfi1-driven medulloblastoma.
Prkca-mediated phosphorylation of LSD1 is required for presynaptic plasticity and hippocampal learning and memory.
CACUL1 reciprocally regulates SIRT1 and LSD1 to repress PPARgamma and inhibit adipogenesis.
These results indicate that LSD1 activators or miRNA antagonists could serve as a therapeutic approach for life-threatening septic shock characterized by dysfunction of hematopoietic stem cells.
MiR-137-3p was upregulated in Bv-injured DRGNs. MiR-137-3p downregulation rescued Bv-induced DRGN apoptosis and neurite retraction. MiR-137-3p and its downstream target LSD1 are inversely associated to regulate anesthetics-induced neurotoxicity in DRGN.
contrary to its role in enhancing DNA virus replication, LSD1 limits RNA virus replication by demethylating and activating IFITM3 which is a host restriction factor for many RNA viruses
Data (including data from studies in transgenic/knockout mice) suggest that Kdm1a-mediated attenuation of Srebf1 transcriptional activities functions as underlying mechanism for suppression of de novo lipogenesis by oxidative stress in white adipose tissue. [Kdm1a = lysine (K)-specific demethylase-1A; Srebf1 = sterol-regulatory element-binding transcription factor-1]
This study demonstrated that LSD1 expression during Olfactory Epithelium neuronal maturation.
LSD1 having a role in silencing additional odorant receptor (OR) alleles, as opposed to being required for the activation of OR alleles, within theolfactory-placode-derived cell line cellular context
results identify the LSD1/NuRD complex as a previously unrecognized modulator for Pax2-mediated neuronal differentiation in the inner ear
Lsd1 regulates skeletal muscle regeneration and directs the fate of satellite cells into myocytes while preventing brown adipocyte differentiation of satellite cells via repressing expression of the novel pro-adipogenic transcription factor Glis1.
LSD1 is continuously required to prevent neurodegeneration. Loss of LSD1 in adult mice leads to paralysis and neurodegeneration in the hippocampus and cortex.
LSD1 consolidates into a single dominant compartment at the edges of chromocenters within nuclei of early post-mitotic cells of the mouse olfactory epithelium. LSD1 complexes with CoREST in early G1 of an immortalized olfactory cell line.
LSD1 is required for the timely expression of MyoD in limb buds.
Lsd1 is a key regulator of gene expression and metabolic function in brown adipose tissue.
The Demethylase Activity of LSD1 Is Required for Brown Adipogenesis.
LSD1 plays a critical role in hair cell regeneration and might represent a novel biomarker and potential therapeutic approach for the treatment of hearing loss.
results suggest that the LSD1-dependent shutdown of Etv2 gene expression may be a significant event required for hemangioblasts to initiate hematopoietic differentiation
Results indicate that LSD1 demethylase activity is required for neuromast development in zebrafish larvae.
LSD1 gene has two transcripts and is expressed in various tissues and relatively higher in ovary, kidney, and spleen.
This gene encodes a nuclear protein containing a SWIRM domain, a FAD-binding motif, and an amine oxidase domain. This protein is a component of several histone deacetylase complexes, though it silences genes by functioning as a histone demethylase. Alternative splicing results in multiple transcript variants.
BRAF35-HDAC complex protein BHC110
, FAD-binding protein BRAF35-HDAC complex, 110 kDa subunit
, amine oxidase (flavin containing) domain 2
, flavin-containing amine oxidase domain-containing protein 2
, lysine (K)-specific demethylase 1
, lysine-specific histone demethylase 1
, lysine-specific histone demethylase 1A
, neuroprotective protein 3
, lysine (K)-specific demethylase 1A