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Human Monoclonal KDM1A Primary Antibody for ChIP, ELISA - ABIN151289
Lim, Janzer, Becker, Zimmer, Schüle, Buettner, Kirfel: Lysine-specific demethylase 1 (LSD1) is highly expressed in ER-negative breast cancers and a biomarker predicting aggressive biology. in Carcinogenesis 2010
Show all 9 Pubmed References
Human Polyclonal KDM1A Primary Antibody for ELISA, WB - ABIN1002761
Shi, Lan, Matson, Mulligan, Whetstine, Cole, Casero, Shi: Histone demethylation mediated by the nuclear amine oxidase homolog LSD1. in Cell 2004
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Human Polyclonal KDM1A Primary Antibody for IHC, ELISA - ABIN1002762
Kouzarides: Histone methylation in transcriptional control. in Current opinion in genetics & development 2002
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Human Monoclonal KDM1A Primary Antibody for IHC, ELISA - ABIN969264
Shi, Matson, Lan, Iwase, Baba, Shi: Regulation of LSD1 histone demethylase activity by its associated factors. in Molecular cell 2005
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Human Polyclonal KDM1A Primary Antibody for IF, IHC (p) - ABIN388023
Forneris, Binda, Vanoni, Mattevi, Battaglioli: Histone demethylation catalysed by LSD1 is a flavin-dependent oxidative process. in FEBS letters 2005
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Human Monoclonal KDM1A Primary Antibody for IHC, ELISA - ABIN966497
Metzger, Wissmann, Yin, Müller, Schneider, Peters, Günther, Buettner, Schüle: LSD1 demethylates repressive histone marks to promote androgen-receptor-dependent transcription. in Nature 2005
Human Polyclonal KDM1A Primary Antibody for ICC, IF - ABIN151968
Su, Ying, Chiu, Lin, Chen, Lin: Involvement of histone demethylase LSD1 in Blimp-1-mediated gene repression during plasma cell differentiation. in Molecular and cellular biology 2009
Human Monoclonal KDM1A Primary Antibody for IF, IHC (p) - ABIN564989
Chen, Obara, Ishida, Suzuki, Yoshizato: Characterization of histone lysine-specific demethylase in relation to thyroid hormone-regulated anuran metamorphosis. in Development, growth & differentiation 2007
Human Polyclonal KDM1A Primary Antibody for ChIP, WB - ABIN5563974
Holdt, Hoffmann, Sass, Langenberger, Scholz, Krohn, Finstermeier, Stahringer, Wilfert, Beutner, Gielen, Schuler, Gäbel, Bergert, Bechmann, Stadler, Thiery, Teupser: Alu elements in ANRIL non-coding RNA at chromosome 9p21 modulate atherogenic cell functions through trans-regulation of gene networks. in PLoS genetics 2013
contrary to its role in enhancing DNA virus replication, LSD1 limits RNA virus replication by demethylating and activating IFITM3 (show IFITM3 Antibodies) which is a host restriction factor for many RNA viruses
Silencing of LSD1 is capable of removing the mono- and dimethyl groups from H3K4, and upregulating the histone acetylation of H3 in JeKo1 and MOLT4 cells. The silencing of LSD1 inhibited cell growth and induced cell apoptosis.
LSD1 and ERRalpha (show ESRRA Antibodies) coregulate several target genes involved in cell migration, including the MMP1 (show MMP1 Antibodies) matrix metallo-protease, also activated through H3K9 demethylation at the transcriptional start site.
concomitant LSD1 and HDAC (show HDAC3 Antibodies) inhibition synergistically induces cell death in rhabdomyosarcoma cells by shifting the ratio of pro- and antiapoptotic BCL-2 (show BCL2 Antibodies) proteins in favor of apoptosis, thereby engaging the intrinsic apoptotic pathway
Results show that LSD1 protein level is elevated in prostate tumors (PCa) and correlate with faster tumor growth in xenograft mouse models. Knockdown of LSD1 reduces PCa cell viability, and gene expression data suggest a dual coregulatory role of LSD1 for VDR, acting as a coactivator and corepressor in a locus-specific manner.
Study showed that repressed HBV cccDNA chromatin state is activated by LSD1 by demethylating H3K9. Also, LSD1 was shown to be recruited to viral promoters in an HBx dependent manner.
LSD1 knockdown has a broad effect on histone lysine methylation.
analysis of a novel cellular stress response mechanism in cancer cells and a key role of LSD1/SIRT1/KU70 dynamic interaction in regulating DNA repair and mutation acquisition
Patients with mutations 6 showed higher rate of achieving major molecular response than those<6 (P=0.0381). Mutations in epigenetic regulator, ASXL1 (show ASXL1 Antibodies), TET2 (show TET2 Antibodies), TET3 (show TET3 Antibodies), KDM1A and MSH6 (show MSH6 Antibodies) were found in 25% of patients. TET2 (show TET2 Antibodies) or TET3 (show TET3 Antibodies), AKT1 (show AKT1 Antibodies) and RUNX1 (show RUNX1 Antibodies) were mutated in one patient each. ASXL1 (show ASXL1 Antibodies) was mutated within exon 12 in three cases
Study demonstrated that LSD1 in cooperation with MYCN controls cell migration and invasiveness of neuroblastoma cells through transcription regulation of the metastatic suppressor NDRG1.
These results indicate that LSD1 activators or miRNA antagonists could serve as a therapeutic approach for life-threatening septic shock characterized by dysfunction of hematopoietic stem cells.
MiR (show MLXIP Antibodies)-137-3p was upregulated in Bv-injured DRGNs. MiR (show MLXIP Antibodies)-137-3p downregulation rescued Bv-induced DRGN apoptosis and neurite retraction. MiR (show MLXIP Antibodies)-137-3p and its downstream target LSD1 are inversely associated to regulate anesthetics-induced neurotoxicity in DRGN.
Data (including data from studies in transgenic/knockout mice) suggest that Kdm1a-mediated attenuation of Srebf1 (show TOM1L2 Antibodies) transcriptional activities functions as underlying mechanism for suppression of de novo lipogenesis by oxidative stress in white adipose tissue. [Kdm1a = lysine (K)-specific demethylase-1A; Srebf1 (show TOM1L2 Antibodies) = sterol-regulatory element-binding transcription factor-1 (show SREBF1 Antibodies)]
This study demonstrated that LSD1 expression during Olfactory Epithelium neuronal maturation.
LSD1 having a role in silencing additional odorant receptor (OR) alleles, as opposed to being required for the activation of OR alleles, within theolfactory-placode-derived cell line cellular context
results identify the LSD1/NuRD complex as a previously unrecognized modulator for Pax2 (show PAX2 Antibodies)-mediated neuronal differentiation in the inner ear
Lsd1 regulates skeletal muscle regeneration and directs the fate of satellite cells into myocytes while preventing brown adipocyte differentiation of satellite cells via repressing expression of the novel pro-adipogenic transcription factor Glis1 (show GLIS1 Antibodies).
LSD1 is continuously required to prevent neurodegeneration. Loss of LSD1 in adult mice leads to paralysis and neurodegeneration in the hippocampus and cortex.
LSD1 consolidates into a single dominant compartment at the edges of chromocenters within nuclei of early post-mitotic cells of the mouse olfactory epithelium. LSD1 complexes with CoREST (show Rcor2 Antibodies) in early G1 of an immortalized olfactory cell line.
LSD1 plays a critical role in hair cell regeneration and might represent a novel biomarker and potential therapeutic approach for the treatment of hearing loss.
results suggest that the LSD1-dependent shutdown of Etv2 (show ETV2 Antibodies) gene expression may be a significant event required for hemangioblasts to initiate hematopoietic differentiation
Results indicate that LSD1 demethylase (show MBD2 Antibodies) activity is required for neuromast development in zebrafish larvae.
LSD1 gene has two transcripts and is expressed in various tissues and relatively higher in ovary, kidney, and spleen.
This gene encodes a nuclear protein containing a SWIRM domain, a FAD-binding motif, and an amine oxidase domain. This protein is a component of several histone deacetylase complexes, though it silences genes by functioning as a histone demethylase. Alternative splicing results in multiple transcript variants.
BRAF35-HDAC complex protein BHC110
, FAD-binding protein BRAF35-HDAC complex, 110 kDa subunit
, amine oxidase (flavin containing) domain 2
, flavin-containing amine oxidase domain-containing protein 2
, lysine (K)-specific demethylase 1
, lysine-specific histone demethylase 1
, lysine-specific histone demethylase 1A
, neuroprotective protein 3
, lysine (K)-specific demethylase 1A