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Human KDM1A Protein expressed in HEK-293 Cells - ABIN2714763
Boxer, Barajas, Tao, Zhang, Khavari: ZNF750 interacts with KLF4 and RCOR1, KDM1A, and CTBP1/2 chromatin regulators to repress epidermal progenitor genes and induce differentiation genes. in Genes & development 2014
analysis of a novel cellular stress response mechanism in cancer cells and a key role of LSD1/SIRT1/KU70 dynamic interaction in regulating DNA repair and mutation acquisition
Patients with mutations 6 showed higher rate of achieving major molecular response than those<6 (P=0.0381). Mutations in epigenetic regulator, ASXL1 (show ASXL1 Proteins), TET2, TET3, KDM1A and MSH6 (show MSH6 Proteins) were found in 25% of patients. TET2 or TET3, AKT1 (show AKT1 Proteins) and RUNX1 (show RUNX1 Proteins) were mutated in one patient each. ASXL1 (show ASXL1 Proteins) was mutated within exon 12 in three cases
Study demonstrated that LSD1 in cooperation with MYCN controls cell migration and invasiveness of neuroblastoma cells through transcription regulation of the metastatic suppressor NDRG1.
Results show that LSD1 could directly bind to the promoter of P21 (show CDKN1A Proteins), inducing H3K4me2 demethylation.
The autophagy induced by 2-PCPA requires LC3 (show MAP1LC3A Proteins)-II processing machinery..2-PCPA treatment induces the change of global gene expression program, including a series of autophagy-related genes, such as SQSTM1/p62 (show SQSTM1 Proteins). Taken together, our data indicate that KDM1A/LSD1 inhibitors induce autophagy through affecting the expression of autophagy-related genes and in a BECN1 (show BECN1 Proteins)-independent manner
LSD1 is specifically mislocalized to pathological protein aggregates in the Alzheimer's disease and frontotemporal dementia patients brain.
these results demonstrate crosstalk between the lysine demethylase (show MBD2 Proteins) KDM1A and the DNA methyltransferase (show DNMT1 Proteins) DNMT1 (show DNMT1 Proteins), which could be involved in carcinogenesis independently of its role in DNA methylation (show HELLS Proteins)
LSD1 inhibition with HCI-2509 decreases the c-MYC (show MYC Proteins) level in poorly differentiated prostate cancer cell lines.
Such a relatively simple strategy uncovered two new classes of LSD1 inhibitors , which reveal unexpected binding modes at the same protein surface, establishing specific and common contacts, and highlight novel routes for the development of compounds targeting epigenetic processes.
we show that KDM1A promotes cancer metastasis in non-small cell lung cancer cells by repressing TIMP3 (tissue inhibitor of metalloproteinase 3 (show TIMP3 Proteins)) expression.
Lsd1 regulates skeletal muscle regeneration and directs the fate of satellite cells into myocytes while preventing brown adipocyte differentiation of satellite cells via repressing expression of the novel pro-adipogenic transcription factor Glis1 (show GLIS1 Proteins).
LSD1 is continuously required to prevent neurodegeneration. Loss of LSD1 in adult mice leads to paralysis and neurodegeneration in the hippocampus and cortex.
LSD1 consolidates into a single dominant compartment at the edges of chromocenters within nuclei of early post-mitotic cells of the mouse olfactory epithelium. LSD1 complexes with CoREST (show Rcor2 Proteins) in early G1 of an immortalized olfactory cell line.
LSD1 is required for the timely expression of MyoD (show MYOD1 Proteins) in limb buds.
Lsd1 is a key regulator of gene expression and metabolic function in brown adipose tissue.
The Demethylase (show MBD2 Proteins) Activity of LSD1 Is Required for Brown Adipogenesis.
through interaction with Zfp516, LSD1 is recruited to UCP1 (show UCP1 Proteins) and other brown adipose tissue-enriched genes.
Study propose that KDM1A is a key regulator of spermatogenesis and germ cell maintenance in the mouse.
This study demonstrates that the FGF19 (show FGF19 Proteins)-SHP (show LAMC1 Proteins)-LSD1 axis maintains homeostasis by suppressing unnecessary autophagic breakdown of cellular components, including lipids, under nutrient-rich postprandial conditions.
This analysis identified that LSD1 is the only lysine demethylase (show MBD2 Proteins) required for myogenic differentiation and that KDM3B (show KDM3B Proteins), KDM6A (show KDM6A Proteins), and KDM8 (show JMJD5 Proteins) are the candidate lysine demethylases required for osteoblast differentiation.
LSD1 plays a critical role in hair cell regeneration and might represent a novel biomarker and potential therapeutic approach for the treatment of hearing loss.
results suggest that the LSD1-dependent shutdown of Etv2 (show ETV2 Proteins) gene expression may be a significant event required for hemangioblasts to initiate hematopoietic differentiation
Results indicate that LSD1 demethylase (show MBD2 Proteins) activity is required for neuromast development in zebrafish larvae.
LSD1 gene has two transcripts and is expressed in various tissues and relatively higher in ovary, kidney, and spleen.
LSD1, EDS1, and PAD4 (show PADI4 Proteins) participate in the regulation of various molecular and physiological processes that influence Arabidopsis fitness.
AtSWP1 and AtCZS represent two main components of a co-repressor complex that fine tunes flowering and is unique to plants.
AtLSD1, similar to HsLSD1, has demethylase (show MBD2 Proteins) activity toward mono- and dimethylated Lys4 but not dimethylated Lys9 and Lys27 of histone 3. [LSD1]
This gene encodes a nuclear protein containing a SWIRM domain, a FAD-binding motif, and an amine oxidase domain. This protein is a component of several histone deacetylase complexes, though it silences genes by functioning as a histone demethylase. Alternative splicing results in multiple transcript variants.
BRAF35-HDAC complex protein BHC110
, FAD-binding protein BRAF35-HDAC complex, 110 kDa subunit
, amine oxidase (flavin containing) domain 2
, flavin-containing amine oxidase domain-containing protein 2
, lysine (K)-specific demethylase 1
, lysine-specific histone demethylase 1
, lysine-specific histone demethylase 1A
, neuroprotective protein 3
, lysine (K)-specific demethylase 1A