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Human Polyclonal BST2 Primary Antibody for IF, IHC (p) - ABIN513817
Iwabu, Fujita, Kinomoto, Kaneko, Ishizaka, Tanaka, Sata, Tokunaga: HIV-1 accessory protein Vpu internalizes cell-surface BST-2/tetherin through transmembrane interactions leading to lysosomes. in The Journal of biological chemistry 2009
Show all 9 Pubmed References
Human Polyclonal BST2 Primary Antibody for ELISA, WB - ABIN1001945
Ohtomo, Sugamata, Ozaki, Ono, Yoshimura, Kawai, Koishihara, Ozaki, Kosaka, Hirano, Tsuchiya: Molecular cloning and characterization of a surface antigen preferentially overexpressed on multiple myeloma cells. in Biochemical and biophysical research communications 1999
Show all 4 Pubmed References
Human Monoclonal BST2 Primary Antibody for IF, IP - ABIN513823
Lv, Wang, Wang, Zuo, Zhu, Kong, Yu: Polarity changes in the transmembrane domain core of HIV-1 Vpu inhibits its anti-tetherin activity. in PLoS ONE 2011
Show all 3 Pubmed References
Human Polyclonal BST2 Primary Antibody for FACS, IHC (p) - ABIN4285447
Crother, Schröder, Karlin, Chen, Shimada, Slepenkin, Alsabeh, Peterson, Arditi: Chlamydia pneumoniae infection induced allergic airway sensitization is controlled by regulatory T-cells and plasmacytoid dendritic cells. in PLoS ONE 2011
Show all 3 Pubmed References
Human Polyclonal BST2 Primary Antibody for ELISA, WB - ABIN4285443
Rollason, Korolchuk, Hamilton, Schu, Banting: Clathrin-mediated endocytosis of a lipid-raft-associated protein is mediated through a dual tyrosine motif. in Journal of cell science 2007
Show all 2 Pubmed References
Human Polyclonal BST2 Primary Antibody for WB - ABIN1327351
Polyak, Vivithanaporn, Maingat, Walsh, Branton, Cohen, Meeker, Power: Differential type 1 interferon-regulated gene expression in the brain during AIDS: interactions with viral diversity and neurovirulence. in FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2013
Human Monoclonal BST2 Primary Antibody for ELISA, WB - ABIN513822
Bruce, Abbink, Wise, Rollason, Galao, Banting, Neil, Digard: Release of filamentous and spherical influenza A virus is not restricted by tetherin. in The Journal of general virology 2012
Human Polyclonal BST2 Primary Antibody for ICC, IF - ABIN4285445
Chiang, Kan, Hsiao, Tang, Hsieh, Chiang, Tsai, Yeh, Hsieh, Liang, Chen, Yu: Bone Marrow Stromal Antigen 2 Is a Novel Plasma Biomarker and Prognosticator for Colorectal Carcinoma: A Secretome-Based Verification Study. in Disease markers 2015
The cytoplasmic domain of HIV-1 Vpu contributes to the physical interaction with, and functional antagonism of chimpanzee BST-2.
Bovine tetherinb (bST2A1) blocks retrovirus release, however, has no effect on cell-to-cell transmission of retroviruses. Anchor and dimerization, but not glycosylation of GPI (show GPI Antibodies)-Linked Membrane Proteins are essential for antiviral activity of bBST2A1.
the detected relationship between BST2 expression and viral load as well as with MX1 (show MX1 Antibodies) indicate a common regulation by the interferon (show IFNA Antibodies) response and suggest rather limited influence of BST2 in vivo on the simian immunodeficiency virus infection outcome
Data suggest that rhesus macaque tetherin and Simian immunodeficiency virus Nef undergo physical interaction leading to removal of tetherin from plasma membrane by clathrin-mediated endocytosis.
A 5-amino-acid sequence in the rhesus BST-2 cytoplasmic domain accounts for the interaction with Vpu and for rhesus BST-2 antagonism by HIV-1 Vpu.
Simian immunodeficiency virus infection results in rapid upregulation of BST-2 on peripheral blood lymphocytes.
Indirect immunofluorescence assay and western blot analysis showed that the MAb was specifically reacted with the overexpressed porcine BST-2 protein in Vero cells. The specific MAb of porcine BST-2 provides a valuable tool for further studies of BST-2 to restrict virus infection
This antibody only reacted with porcine BST-2 protein and not with human, monkey, or mouse BST-2 protein
PRRSV counteract the antiviral functions of IFITM1 (show IFITM1 Antibodies) and Tetherin by the interaction of the Nsp3 (show SH2D3C Antibodies) with IFITM1 (show IFITM1 Antibodies) and the E protein with Tetherin.
The BST2 had antiviral activity against vesicular stomatitis virus, avian influenza virus and Porcine reproductive and respiratory syndrome virus.
findings support the notion that NAbs can induce ADCC. They highlight that while BST2 antagonism by HIV promotes ADCC evasion, strategies aimed at restoring BST2 restriction could improve anti-HIV responses and potentially provide a means to eliminate reactivated cells in latent reservoirs.
BST2 likely mediates platinum resistance in nasopharyngeal cancer via NF-kappaB (show NFKB1 Antibodies) signaling
These data collectively suggest that the human parainfluenza virus type 2 V protein inhibits tetherin expression induced by several external stimuli.
These results suggest that tetherin antagonism by V proteins is common among the genus Rubulavirus.
High BST2 expression is associated with Esophageal, Gastric, or Colorectal Cancer.
Two additional regulators of BST2 constitutive ubiquitylation and sorting to the lysosomes: the E3 ubiquitin ligases NEDD4 and MARCH8, are reported.
Coimmunoprecipitation studies indicated that non-glycosylated tetherin is stabilized through the formation of a ternary SGTA (show SGTA Antibodies)/Vpu/tetherin complex. Although the results do not provide support for a physiological function of SGTA (show SGTA Antibodies) in HIV-1 replication, they demonstrate that SGTA (show SGTA Antibodies) overexpression regulates tetherin expression and stability, thus providing insights into the function of SGTA (show SGTA Antibodies) in endoplasmic reticulum translocation
Importantly, the authors demonstrate for the first time that the HIV-2 Env (show ERVW-1 Antibodies) induces NF-kappaB (show NFKB1 Antibodies) activation in HEKappa293T cells. Furthermore, the anti-BST-2 activity of the HIV-2 Env (show ERVW-1 Antibodies) is not sufficient to completely inhibit NF-kappaB (show NFKB1 Antibodies) activity.
Data revealed that under a nutrient deficient condition, CD317 functions as an anti-apoptotic factor through AIF (show AIFM1 Antibodies)-mediated caspase (show CASP3 Antibodies) and autophagy-independent manner.
findings lead us to believe that BISPR and BST2 may regulate egress of HEV virions into bile in vivo. This system may also be used to scale up virus production in vitro
contain the spread of herpes simplex virus type 1 in vivo, STING-dependent signaling leads to the upregulation of tetherin, a viral restriction factor
Tetherin-mediated retention of R-defective virions on the cell surface could enhance syncytium formation.
Bone marrow stromal antigen 2-mediated dendritic cell activation as a critical mechanism for how Tetherin influenced retrovirus cell-mediated immune responses that subsequently inhibited retrovirus replication in vivo.
BST-2 does not have a role in modulating Influenza A Virus in the mouse model of infection
Although Bst2 prevented Measles virus (MV) release from nonneuronal cells, its deletion had no effect on viral pathogenesis in MV-challenged mice.
BST-2 contributes to the emergence of neoplasia and malignant progression of breast cancer. BST-2 enhances cancer cell adhesion, anchorage-independency, migration, and invasion.
BST-2 protects lymphoid tissues from Chikungunya virus (CHIKV) infection and regulates CHIKV-induced inflammatory response by the host.
TLR4 (show TLR4 Antibodies) and PI3K effects on BST-2 induction are at the level of transcription.
Tetherin acts as a modulator of the cell-mediated immune response against retrovirus infection in vivo.
These findings suggest that BST2 antagonism by Vpu is critical for efficient early viral expansion and dissemination during acute infection and as such is likely to confer HIV-1 increased transmission fitness.
Bone marrow stromal cells are involved in the growth and development of B-cells. The specific function of the protein encoded by the bone marrow stromal cell antigen 2 is undetermined\; however, this protein may play a role in pre-B-cell growth and in rheumatoid arthritis.
bone marrow stromal antigen 2
, bone marrow stromal cell antigen 2
, HM1.24 antigen
, DAMP-1 protein homolog
, protein DAMP-1