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anti-Human CLEC2D Antibodies:
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Human Monoclonal CLEC2D Primary Antibody for IHC (p), ELISA - ABIN565412
Roth, Mittelbronn, Wick, Meyermann, Tatagiba, Weller: Malignant glioma cells counteract antitumor immune responses through expression of lectin-like transcript-1. in Cancer research 2007
Show all 6 Pubmed References
Human Monoclonal CLEC2D Primary Antibody for ELISA, WB - ABIN949236
Williams, Eaton, Jones, Rengan, Burshtyn: Vaccinia virus Western Reserve induces rapid surface expression of a host molecule detected by the antibody 4C7 that is distinct from CLEC2D. in Microbiology and immunology 2016
Human Polyclonal CLEC2D Primary Antibody for CyTOF, FACS - ABIN4900423
Llibre, Garner, Partridge, Freeman, Klenerman, Willberg: Expression of lectin-like transcript-1 in human tissues. in F1000Research 2017
Human Monoclonal CLEC2D Primary Antibody for FACS - ABIN4897677
Dupuy, Lambert, Zucman, Choukem, Tognarelli, Pages, Lebbé, Caillat-Zucman: Human Herpesvirus 8 (HHV8) sequentially shapes the NK cell repertoire during the course of asymptomatic infection and Kaposi sarcoma. in PLoS pathogens 2012
Human Monoclonal CLEC2D Primary Antibody for FACS - ABIN4897676
Chalan, Bijzet, Huitema, Kroesen, Brouwer, Boots: Expression of Lectin-Like Transcript 1, the Ligand for CD161, in Rheumatoid Arthritis. in PLoS ONE 2015
Blocking LLT1-NKRP1A (show KLRB1 Antibodies) interaction will make prostate cancer cells susceptible to killing by NK cells, suggesting a therapeutic option for treatment of prostate cancer.
these data suggest that LLT1-CD161 (show KLRB1 Antibodies) interactions play a novel and important role in B cell maturation (show TNFRSF17 Antibodies) within the Germinal center in humans.
In RA joints, LLT1 is expressed by cells of the monocyte/macrophage lineage.
The hexamer of glycosylated LLT1 consists of three classical dimers. The hexameric packing may indicate a possible mode of interaction of C-type lectin (show MBL2 Antibodies)-like proteins in the glycosylated form.
One polymorphism in LLT1 was found to be associated with our Crohn's Disease population (P<0.034).Our Ulcerative Colitis cohort was not associated with the variation in LLT1 (P=0.33)
LLT1 and CD161 (show KLRB1 Antibodies) have roles in modulating immune responses to pathogens; and interferon-gamma (show IFNG Antibodies) contributes to modulate immune responses
Molecular basis for LLT1 protein recognition by human CD161 (show KLRB1 Antibodies) protein (NKRP1A/KLRB1 (show KLRB1 Antibodies)).
Data show that only CLEC2D isoform 1 (LLT1) is expressed on the cell surface.
LLT1 used Src (show SRC Antibodies)-PTK, p38 (show CRK Antibodies) and ERK (show EPHB2 Antibodies) signalling pathways, but not PKC (show PRRT2 Antibodies), PI3K (show PIK3CA Antibodies) or calcineurin pathways, to increase production of IFN-gamma (show IFNG Antibodies) by human natural killer cells.
LLT1 induces Interferon (show IFNA Antibodies) Type II production by natural killer cells.
Data suggest that killer cell lectin-like receptors NKR (show TACR3 Antibodies)-P1B:Clr-b (Klrb1 (show KLRB1 Antibodies):Clec2d) interactions may provide a model for human hematopoietic cell transplants.
Reductions of Clr-b may be involved in sensitizing poxvirus-infected cells to natural killer (NK) cells.
LLT1 and CD161 have roles in modulating immune responses to pathogens; and interferon-gamma (show IFNG Antibodies) contributes to modulate immune responses
cloning and characterization of a cognate ligand, Ocil, for the inhibitory NK receptors (NKR)-P1B and NKR-P1D. Ocil/Clr-b is displayed at high levels on nearly all hematopoietic cells, in a pattern that is similar to that of class I MHC molecules.
Data show that osteoclast inhibitory lectin (OCIL) binds a range of physiologically important glycosaminoglycans, and this property may modulate OCIL actions upon other cells.
Limited divergence of the BALB/c Nkrp1-Ocil/Clr region helps explain a longstanding confusion regarding the strain-specific NK1.1 alloantigen reactivity of mouse natural killer cells.
OCIL is a physiological negative regulator of bone.
PTHrp(1-34) regulates OCIL expression in vitro through cAMP/PKA, Ca(2 (show CA2 Antibodies)+)/CaMK II (show CAMK2B Antibodies), and MAPK (show MAPK1 Antibodies) signaling pathways.
Identification of a novel family of genes, named Clr (show CALCR Antibodies), encoding C-type lectin-like molecules, which maps in the natural killer (NK) gene complex (NKC) on mouse Chromosome 6.
Mouse Nkrp1d and Nkrp1f bind specific C-type lectin-related (Clr (show CALCR Antibodies)) molecules. Nkrp1d mediated inhibition when recognizing Clrb, a molecule expressed in dendritic cells and macrophages. Nkrp1 and Clr (show CALCR Antibodies) are intertwined in a genetically conserved NKC region.
This gene encodes a member of the natural killer cell receptor C-type lectin family. The encoded protein inhibits osteoclast formation and contains a transmembrane domain near the N-terminus as well as the C-type lectin-like extracellular domain. Several alternatively spliced transcript variants have been identified for this gene.
C-type lectin domain family 2 member D
, C-type lectin related f
, C-type lectin superfamily 2, member D
, lectin-like NK cell receptor
, lectin-like transcript 1
, osteoclast inhibitory lectin
, C-type lectin-domain family 2 member D
, C-type lectin-related protein B
, lectin-like transmembrane protein
, C-type lectin domain family 2 member D5
, C-type lectin domain family 2, member D
, C-type lectin domain family 2 member H-like