Browse our anti-CLEC2D (CLEC2D) Antibodies

Human C-Type Lectin Domain Family 2, Member D (CLEC2D) interaction partners

1. These results show that susceptibility of normal articular chondrocytes to lysis by NK cells is modulated by NKR-P1A (show KLRB1 Antibodies)/LLT1 interactions. Thus, NKR-P1A (show KLRB1 Antibodies)/LLT1 interaction might provide some novel target for therapeutic interventions in the course of pathological cartilage injury.

2. Blocking LLT1-NKRP1A (show KLRB1 Antibodies) interaction will make prostate cancer cells susceptible to killing by NK cells, suggesting a therapeutic option for treatment of prostate cancer.

3. these data suggest that LLT1-CD161 (show KLRB1 Antibodies) interactions play a novel and important role in B cell maturation (show TNFRSF17 Antibodies) within the Germinal center in humans.

4. In RA joints, LLT1 is expressed by cells of the monocyte/macrophage lineage.

5. The hexamer of glycosylated LLT1 consists of three classical dimers. The hexameric packing may indicate a possible mode of interaction of C-type lectin (show MBL2 Antibodies)-like proteins in the glycosylated form.

6. One polymorphism in LLT1 was found to be associated with our Crohn's Disease population (P<0.034).Our Ulcerative Colitis cohort was not associated with the variation in LLT1 (P=0.33)

7. LLT1 and CD161 (show KLRB1 Antibodies) have roles in modulating immune responses to pathogens; and interferon-gamma (show IFNG Antibodies) contributes to modulate immune responses

8. Molecular basis for LLT1 protein recognition by human CD161 (show KLRB1 Antibodies) protein (NKRP1A/KLRB1 (show KLRB1 Antibodies)).

9. Data show that only CLEC2D isoform 1 (LLT1) is expressed on the cell surface.

10. LLT1 used Src (show SRC Antibodies)-PTK, p38 (show CRK Antibodies) and ERK (show EPHB2 Antibodies) signalling pathways, but not PKC (show PRRT2 Antibodies), PI3K (show PIK3CA Antibodies) or calcineurin pathways, to increase production of IFN-gamma (show IFNG Antibodies) by human natural killer cells.

Mouse (Murine) C-Type Lectin Domain Family 2, Member D (CLEC2D) interaction partners

1. these findings demonstrate that Clr-b is an IFN-stimulated gene on healthy bystander cells, in addition to a missing-self marker on MCMV-infected cells, and thereby enhances the dynamic range of innate self-nonself discrimination by NK cells

2. Data suggest that killer cell lectin-like receptors NKR (show TACR3 Antibodies)-P1B:Clr-b (Klrb1 (show KLRB1 Antibodies):Clec2d) interactions may provide a model for human hematopoietic cell transplants.

3. Reductions of Clr-b may be involved in sensitizing poxvirus-infected cells to natural killer (NK) cells.

4. LLT1 and CD161 have roles in modulating immune responses to pathogens; and interferon-gamma (show IFNG Antibodies) contributes to modulate immune responses

5. cloning and characterization of a cognate ligand, Ocil, for the inhibitory NK receptors (NKR)-P1B and NKR-P1D. Ocil/Clr-b is displayed at high levels on nearly all hematopoietic cells, in a pattern that is similar to that of class I MHC molecules.

6. Data show that osteoclast inhibitory lectin (OCIL) binds a range of physiologically important glycosaminoglycans, and this property may modulate OCIL actions upon other cells.

7. Limited divergence of the BALB/c Nkrp1-Ocil/Clr region helps explain a longstanding confusion regarding the strain-specific NK1.1 alloantigen reactivity of mouse natural killer cells.

8. OCIL is a physiological negative regulator of bone.

9. PTHrp(1-34) regulates OCIL expression in vitro through cAMP/PKA, Ca(2 (show CA2 Antibodies)+)/CaMK II (show CAMK2B Antibodies), and MAPK (show MAPK1 Antibodies) signaling pathways.

10. Identification of a novel family of genes, named Clr (show CALCR Antibodies), encoding C-type lectin-like molecules, which maps in the natural killer (NK) gene complex (NKC) on mouse Chromosome 6.