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anti-Human F2RL1 Antibodies:
anti-Mouse (Murine) F2RL1 Antibodies:
anti-Rat (Rattus) F2RL1 Antibodies:
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Human Monoclonal F2RL1 Primary Antibody for FACS - ABIN4898819
Amiable, Tat, Lajeunesse, Duval, Pelletier, Martel-Pelletier, Boileau: Proteinase-activated receptor (PAR)-2 activation impacts bone resorptive properties of human osteoarthritic subchondral bone osteoblasts. in Bone 2009
Show all 2 Pubmed References
Dog (Canine) Polyclonal F2RL1 Primary Antibody for WB - ABIN2788314
Yau, Liu, Fairlie: Toward drugs for protease-activated receptor 2 (PAR2). in Journal of medicinal chemistry 2013
plays a direct role in melanogenesis by increasing stem cell factor (show KITLG Antibodies) secretion from keratinocytes
Neutrophil elastase (show ELANE Antibodies) enhances IL-12p40 production by lipopolysaccharide-stimulated macrophages via transactivation of the PAR-2/EGFR (show EGFR Antibodies)/TLR4 (show TLR4 Antibodies) signaling pathway
PAR2 is crucial for TGF-beta1 (show TGFB1 Antibodies)-induced cell motility by its ability to sustain expression of ALK5 (show TGFBR1 Antibodies). Therapeutically targeting PAR2 may thus be a promising approach in preventing TGF-beta (show TGFB1 Antibodies)-dependent driven metastatic dissemination in PDAC and possibly other stroma-rich tumour types.
Protease-activated receptor 2 (PAR2) is present in human skin.
PAR2 signaling promotes cancer cell migration through miR (show MLXIP Antibodies)-205/BMPR1B (show BMPR1B Antibodies) pathway in human colorectal carcinoma.
findings showed in intestinal epithelial cells that PAR-2 activation leads to polarized IL-8 (show IL8 Antibodies) secretion in accordance with the side of PAR-2 activation, apical or basolateral, but do not affect ubiquitin proteasome system; demonstrate that PAR-2 activation leads to an increased IL-8 (show IL8 Antibodies) production and can affect proteasome system, particularly when PAR-2 activation was induced in the apical side
TF-induced microvessel stabilization is regulated via PAR2-SMAD3 (show SMAD3 Antibodies) that is indispensable for the maintenance of vascular integrity.
PAR-2- and PAR-1 (show MARK2 Antibodies)-mediated TNF-alpha (show TNF Antibodies) release from monocytes suggests that these unique protease receptors are involved in the pathogenesis of inflammation.
Results indicate that chymotrypsin-like serine protease (show F2 Antibodies) enhances soluble fms-like tyrosine kinase 1 (show FLT1 Antibodies) production through protease-activated receptor-2 in trophoblast cells and thus plays an important additional role in preeclampsia pathogenesis.
crystal structures of PAR2 in complex with two distinct antagonists and a blocking antibody
thrombin (show F2 Antibodies) is increased in a mouse model of cancer cachexia in a partially interleukin-6 (show IL6 Antibodies) dependent manner
Data show that activated protein C (show PROC Antibodies) signals via protease activated receptors PAR2/PAR3 (show F2RL2 Antibodies) to expand Treg cells, mitigating the disease in mice.
PAR2 plays an important and previously unrecognised anti-apoptotic role in T cell development
thrombin (show F2 Antibodies) has a role in diet-induced obesity through fibrin-driven inflammation
PAR2 modulation was sufficient to induce islet cell transdifferentiation in the absence of beta-cells.
Our results are suggestive that PAR2 inhibition may play a role in the treatment of diseases with increased inflammatory responses in renal systems
PAR2/GSK3beta is a novel pathway that plays a critical role in the regulation of stem/progenitor cell survival and proliferation in normal colon crypts and colon cancer.
Enhanced FXa (show F10 Antibodies) and PAR2 exacerbate DN and that both are promising targets for preventing diabetic nephropathy.
PAR2 is critically important in the pathogenesis of adenine-induced tubular injury
The levels of miR (show MLXIP Antibodies)-223, miR (show MLXIP Antibodies)-339 and miR (show MLXIP Antibodies)-21, which are associated with platelet activation, were elevated in pooled mouse plasma exosomes before thrombosis and enriched in thrombin (show F2 Antibodies)-stimulated platelet-derived exosomes in vitro.
PAR1 (show F2R Antibodies) and PAR2 regulate endothelial NO synthase (show NOS Antibodies) phosphorylation and activity through G(12/13) and G(q), delineating the signaling pathways by which the proteases act on protease-activated receptors to modulate endothelial functions.
Coagulation factor II (thrombin) receptor-like 1 (F2RL1) is a member of the large family of 7-transmembrane-region receptors that couple to guanosine-nucleotide-binding proteins. F2RL1 is also a member of the protease-activated receptor family. It is activated by trypsin, but not by thrombin. It is activated by proteolytic cleavage of its extracellular amino terminus. The new amino terminus functions as a tethered ligand and activates the receptor. The F2RL1 gene contains two exons and is widely expressed in human tissues. The predicted protein sequence is 83% identical to the mouse receptor sequence.
Proteinase-activated receptor 2
, G-protein coupled receptor 11
, coagulation factor II receptor-like 1
, protease-activated receptor 2
, proteinase-activated receptor 2
, thrombin receptor-like 1
, Protease-activated receptor-2
, proteinase-activated receptor-2
, Proteinase-activated receptor-2 G protein-coupled receptor 11
, Proteinase-activated receptor-2, G protein-coupled receptor 11