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gene polymorphism is associated with increased colorectal cancer risk in the Han Chinese population
we describe monozygotic twins and one full-term newborn with ACD (show ACD Proteins) and gastrointestinal malformations caused by de novo mutations of FOXF1 on the maternal-inherited alleles.
reported the first familial case of ACDMVP as a result of maternal somatic mosaic FOXF! mutation, which provided additional evidence for this novel imprinting disorder
FOXF1 promotes prostate tumor growth and progression by activating ERK5 (show MAPK7 Proteins) signaling
the R139Q substitution in FOXF1 causes infantile hypertrophic pyloric stenosis in a family and implies a novel pathological pathway for the condition
Single-nucleotide polymorphisms FOXF1 rs9936833 and MHC rs9257809 remained significantly associated with presence of gastroesophageal acid reflux. The association for risk allele C in FOXF1 rs9936833 and risk allele A in MHC rs9257809 with the presence of acid reflux suggests a potential pathophysiologic mechanism for the role of genetic influences in Barret Esophagus development.
FOXF1 mutations may have an extremely variable phenotype, possibly as a result of somatic mosaicism and complex gene regulation.
There were decreased levels of Gsa (show GNAS Proteins), FOXF1, CREB1 (show CREB1 Proteins), and phosphorylated CREB1 (show CREB1 Proteins) proteins in intestinal muscle layers of patients with chronic intestinal pseudo-obstruction, compared with tissues from controls.
Data show that MeCP2 promotes gastric cancer (GC) cell proliferation via FOXF1-mediated Wnt5a (show WNT5A Proteins)/beta-Catenin (show CTNNB1 Proteins) signaling pathway, and suppresses GC cell apoptosis through MYOD1 (show MYOD1 Proteins)-mediated Caspase-3 (show CASP3 Proteins) signaling pathway.
Results show that FoxF1 increases invasiveness of breast cancer cells by upregulating LOX (show LOX Proteins).
Results provide support for the function of FoxF1 in the development of visceral mesoderm and the organogenesis of the gut (show GUSB Proteins).
It is concluded that during early pseudoglandular stage of lung development Ptch1 (show PTCH1 Proteins) patterns Fgf10 (show FGF10 Proteins) and regulates Foxf1 expression in the lung mesenchyme to direct branch formation and this is essential for proper lobe formation and lung function.
Expression of Bmp4 (show BMP4 Proteins) in the ureteric mesenchyme depends on HH signaling and Foxf1, and that exogenous BMP4 (show BMP4 Proteins) rescued cell proliferation and epithelial differentiation in ureters with abrogated HH signaling or FOXF1 function.
The Gli (show GLI1 Proteins) increased the activity of one of these long-range enhancers, which was specific to distal blood vessel, suggesting that Shh (show SHH Proteins) regulates Foxf1 transcription in pulmonary distal blood vessel formation.
Data indicate that forkhead box F1 (Foxf1) deletion from endothelial cells decreases the abundance of sphingosine 1-phosphate receptor 1 (S1PR1 (show S1PR1 Proteins)).
Targeted Resequencing of 29 Candidate Genes and Mouse Expression Studies Implicate ZIC3 (show ZIC3 Proteins) and FOXF1 in Human VATER/VACTERL Association
novel Shh (show SHH Proteins)-Foxf-Fgf18 (show FGF18 Proteins)-Shh (show SHH Proteins) circuit in the palate development molecular network, in which Foxf1 and Foxf2 (show FOXF2 Proteins) regulate palatal shelf growth downstream of Shh (show SHH Proteins) signaling, at least in part, by repressing Fgf18 (show FGF18 Proteins) expression
findings suggest that Foxf1 may serve as a target gene to disrupt progression of liver fibrosis and DBTC might provide a potentially feasible and effective tool for HSC (show FUT1 Proteins)-specific delivery of therapeutic RNA
Our findings implicate Foxf genes(Foxf1a and Foxf2 (show FOXF2 Proteins) ) in atrioventricular septation, describe the molecular underpinnings of the genetic interaction between Hedgehog (show SHH Proteins) signaling and Tbx5 (show TBX5 Proteins)
Data indicate FOXF1 transcription factor is required for the formation of embryonic vasculature by regulating endothelial genes critical for vascular development and vascular endothelial growth factor (show VEGF Proteins) signaling.
This gene belongs to the forkhead family of transcription factors which is characterized by a distinct forkhead domain. The specific function of this gene has not yet been determined\; however, it may play a role in the regulation of pulmonary genes as well as embryonic development.
forkhead box F1
, forkhead box protein F1
, forkhead box F protein
, Forkhead, drosophila, homolog-like 5
, forkhead-related activator 1
, forkhead-related protein FKHL5
, forkhead-related transcription factor 1
, fork head domain-related protein 13
, forkhead box protein F1-A
, forkhead transcription factor
, HNF-3/forkhead homolog 8
, forkhead box F1a
, hepatocyte nuclear factor 3 forkhead homolog 8
, HNF-3/fork-head homolog-5 (HFH-5)
, forkhead box protein I2
, hepatocyte nuclear factor 3 forkhead homolog 5