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anti-Mouse (Murine) MUC4 Antibodies:
anti-Human MUC4 Antibodies:
anti-Rat (Rattus) MUC4 Antibodies:
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Human Monoclonal MUC4 Primary Antibody for IHC (p), ELISA - ABIN561876
Smalley, Sheman, Nelson, Theodorescu: Isolation and identification of potential urinary microparticle biomarkers of bladder cancer. in Journal of proteome research 2008
Show all 4 Pubmed References
Human Polyclonal MUC4 Primary Antibody for ICC, IF - ABIN4336444
Milara, Morell, Ballester, Armengot, Morcillo, Cortijo: MUC4 impairs the anti-inflammatory effects of corticosteroids in patients with chronic rhinosinusitis with nasal polyps. in The Journal of allergy and clinical immunology 2016
the role of Muc4 in driving intestinal inflammation and inflammation-associated tumorigenesis
Results show that while MUC4 is highly expressed in the mouse uterus, it is not a major mucin (show SLC13A2 Antibodies) in normal human endometrium. Rather, MUC4 is a potential marker of endometrial adenocarcinoma in a subset of patients.
Using the Pdx1 (show PDX1 Antibodies)-Cre; LStopL-K-rasG12D mouse model of pancreatic carcinogenesis, in vivo early Muc4 neo-expression of in pancreatic intraepithelial neoplastic lesions induced by mutated hK-ras is correlated with the ERK (show EPHB2 Antibodies), JNK (show MAPK8 Antibodies) and NF-kappaB (show NFKB1 Antibodies) signaling pathways.
Data show that Muc4 is upregulated and interacts with erbB2 (show ERBB2 Antibodies) in gallbladders from BK5.erbB2 (show ERBB2 Antibodies) mice suggesting its important role during gallbladder carcinogenesis and/or cancer growth by potentiating erbB2 (show ERBB2 Antibodies) signaling.
This study delineates the association and the downstream mechanisms of MUC4-regulated elevation of lipocalin-2 (show LCN2 Antibodies) and its clinical significance for prognosis of pancreatic cancer.
MUC4-NIDO domain significantly contributes to the MUC4-mediated metastasis of PC cells
ErbB2 (show ERBB2 Antibodies) and MUC4, which interact physically, activate different intracellular signalling pathways to regulate biological properties of CAPAN-2 pancreatic cancer cells
As a luminal surface component, the MUC4 is situated to contribute to the non-adhesive luminal surface and to act as an intrinsic protection and survival factor for blood vessels
MUC4 is regulated at the transcriptional level by CDX-1 (show CDX1 Antibodies) and -2, HNF-1 alpha (show HNF1A Antibodies) and -1 beta, FOXA1 (show FOXA1 Antibodies)/A2, HNF-4 alpha (show HNF4A Antibodies) and -4 gamma, and GATA-4 (show GATA4 Antibodies), -5, and -6 factors in a cell-specific manner
the expression of mucins 1 to 4 and trefoil factor 3 (show TFF3 Antibodies) was down-regulated in the ileum and colon of conventional and reconventionalized mice compared with germ-free animals
MUC1 and MUC4 expression are increased by hypoxia and DNA hypomethylation; this status is statistically associated with development of distant metastasis, tumor stage and overall survival for pancreatic ductal adenocarcinoma (stage IIA and IIB) patients
Study provides evidence that AMOP domain plays the key role in MUC4-mediated tumor angiogenesis and metastasis of pancreatic cancer cells partly through the NOTCH3 (show NOTCH3 Antibodies) signaling and its downstream target genes: VEGF-A (show VEGFA Antibodies), MMP-9 (show MMP9 Antibodies) and ANG-2 (show ANGPT2 Antibodies).
elevated levels of bile acid increase the tumorigenic potential of pancreatic cancer cells by inducing FXR (show NR1H4 Antibodies)/FAK (show PTK2 Antibodies)/c-Jun (show JUN Antibodies) axis to upregulate MUC4 expression.
High MUC4 expression is associated with CRLF2 (show CRLF2 Antibodies)-rearranged acute lymphoblastic leukemia.
Low expression of MUC4 was associated with favorable survival, whereas high MUC4 expression did not correlate with survival in resectable pancreatic cancer patients receiving adjuvant gemcitabine treatment.
the present study provides evidence that hypoxia negatively regulates MUC4 expression in PC by affecting its stability.
Studies indicate that a positive or high expression level of mucin 4 (MUC4) was significantly related to poor survival in patients with resected cholangiocarcinoma (CC).
MUC4beta participates in the corticosteroid resistance process, inhibiting normal GRalpha nuclear function. The high expression of MUC4 in patients with CRSwNP might participate in corticosteroid resistance.
Data indicate that microRNA miR (show MLXIP Antibodies)-211 can directly target the 3'UTR (show UTS2R Antibodies) of mucin-4 (MUC4) and inhibit its expression at both mRNA and protein levels.
The main significance of this work is the discovery of EPO (show EPO Antibodies) as a novel ligand for the HER2 (show ERBB2 Antibodies) receptor. Following HER2 (show ERBB2 Antibodies) activation, EPO (show EPO Antibodies) induces activation of FAK (show PTK2 Antibodies) and subsequent activation of beta1-integrin, via inside-out signaling. This complex results in downstream activation of ERK1/2 (show MAPK1/3 Antibodies) and a sustained up regulation of both MUC4 and the HER2 (show ERBB2 Antibodies) receptor
Polymorphism of FUT1 (show FUT1 Antibodies) and MUC4 associated with resistance to colibacteriosis was determined.
Haplotype phylogeny analyses indicated that MUC4 had evolved divergently in Chinese and Western pigs.
A SNP in exon 7 of the mucin 4 (MUC4) gene (DQ848681:g.8227C>G), shown to be in close linkage disequilibrium with the F4bcR locus, has been used as marker to identify ETEC susceptible pigs.
data suggest that MUC4 could play an important role in the establishment of an optimal uterine environment that would increase embryonic survival during pig gestation
The major constituents of mucus, the viscous secretion that covers epithelial surfaces such as those in the trachea, colon, and cervix, are highly glycosylated proteins called mucins. These glycoproteins play important roles in the protection of the epithelial cells and have been implicated in epithelial renewal and differentiation. This gene encodes an integral membrane glycoprotein found on the cell surface, although secreted isoforms may exist. At least two dozen transcript variants of this gene have been found, although for many of them the full-length transcript has not been determined or they are found only in tumor tissues. This gene contains a region in the coding sequence which has a variable number (>100) of 48 nt tandem repeats.
, mucin 4, ASGP
, pancreatic adenocarcinoma mucin
, testis mucin
, mucin 4, tracheobronchial
, tracheobronchial mucin
, pre-sialomucin complex
, sialomucin ascites sialoglycoprotein-1
, sialomucin complex