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Human Polyclonal SUPT6H Primary Antibody for ChIP, ICC - ABIN4355771
Kronemann, Hagemeier, Cygnar, Phillips, Bresnahan: Binding of the human cytomegalovirus (HCMV) tegument protein UL69 to UAP56/URH49 is not required for efficient replication of HCMV. in Journal of virology 2010
Show all 6 Pubmed References
Human Polyclonal SUPT6H Primary Antibody for IP - ABIN251024
Cygnar, Hagemeier, Kronemann, Bresnahan: The cellular protein SPT6 is required for efficient replication of human cytomegalovirus. in Journal of virology 2012
SPT6 acts as a master regulator of Pol II elongation, favoring productive protein coding over non-productive and potentially deleterious lncRNA transcription.
cryo-EM structure of an activated elongation complex of Sus scrofa Pol II and Homo sapiens DSIF, PAF and SPT6 was determined at 3.1 A resolution and compared to the structure of the paused elongation complex formed by Pol II, DSIF and NELF
Altogether, these results indicate that a complex containing LEDGF/p75, Iws1, and Spt6 participates in regulating postintegration steps of HIV latency.
identified fibronectin, a component of the extracellular matrix and a mesenchymal marker, as a transcriptional target of Pak1 signaling
Spt6 is a unique histone chaperone capable of regulating the histone epigenetic state of both AID targets and the AID locus.
These results show that intracellular levels of Spt6 are fine-tuned by PAAF1 and proteasome, which is required for HIV-1 transcription and extends to cellular genes implicated in cancer.
Abolishing UL69's ability to interact with the SPT6 protein inhibited human cytomegalovirus replication.
Knockdown of Spt6 resulted in severe reduction of class switch recombination in the endogenous Ig locus in B cells.
Reults establish that human Spt6 (hSpt6) is a classic transcription elongation factor that enhances the rate of RNA polymerase II elongation.
SPT6 facilitates IFN-induced transcription, highlighting its critical role in gene activation.
Iws1 is expressed in all adult organs and it is an essential gene for mouse embryonic development.
Biochemical as well as functional experiments revealed that Spt6 could compete for binding of the PRC2 methyltransferase Ezh2 to Suz12 and reduce PRC2 chromatin engagement.
These data indicate that, through cooperation with PolII and KDM6A, Spt6 orchestrates removal of H3K27me3, thus controlling developmental gene expression and cell differentiation.
Thus binding of Spt6 to Ser2-P RNAPII provides a cotranscriptional mechanism to recruit Iws1, REF1/Aly, and associated mRNA processing, surveillance, and export factors to responsive genes.
recombinant Spt6 binds selectively to a stretch of uninterrupted consensus repeats located in the N-terminal half of the CTD and recruits Iws1
The elongation factors Pandora/Spt6 and Foggy/Spt5 promote transcription in the zebrafish embryo. (Pandora/Spt6)
Spt6 is essential for the transcriptional response to activation of the Notch pathway.
Acts to stimulate transcriptional elongation by RNA polymerase II (By similarity).
, tat-CT2 protein
, tat-cotransactivator 2 protein
, transcription elongation factor SPT6
, suppressor of Ty 6 homolog
, protein pandora
, suppressor of Ty 6 homolog (S. cerevisiae)
, Spt6 gene product
, SUPT6H,-like protein to suppressor of ty 6
, transcription elongation factor SPT6-like
, hypothetical protein