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electron cryo-microscopy structure of the most widespread CAN channel, human TRPM4, bound to the agonist Ca(2 (show CA2 Proteins)+) and the modulator decavanadate
TRPM4 protein expression is up-regulated in diffuse large B cell lymphoma
study presents 2 structures of TRPM4 embedded in lipid nanodiscs at ~3-angstrom resolution, as determined by single-particle cryo-electron microscopy; these structures, with and without calcium bound, reveal a general architecture for this major subfamily of TRP (show TBPL1 Proteins) channels and a well-defined calcium-binding site within the intracellular side of the S1-S4 domain
Study supports the view that TRPM4 variants could be responsible for about 2% of LQT (show KCNQ1 Proteins) syndrome cases. The impact of these variants results in electrophysical disturbances.
A large pedigree diagnosed with progressive familial heart block type I was linked to a mutation of the TRPM4 ion channel.
Identify TRPM4 as a regulator of store operated calcium entry in prostate tumor cells, and demonstrate a role for TRPM4 in cancer cell migration.
TRPM4 channels regulate human detrusor smooth muscle excitability and contractility and are critical determinants of human urinary bladder function
TRPM4 protein expression is widely expressed in benign and cancerous prostate tissue
new insight into the ligand binding domains of the TRPM4 channel
Casein kinase 1 (show CSNK1A1 Proteins) phosphorylates S839 and is responsible for the basolateral localization of TRPM4.
The findings of this study demonstrated a novel molecular mechanism involving the SUR1 (show ABCC8 Proteins)-TRPM4-AQP4 (show AQP4 Proteins) complex to account for bulk water influx during astrocyte swelling.
Calcium studies demonstrated that TRPM4 channel negatively regulates calcium entry providing support for activation of the Cn-NFAT (show NFATC1 Proteins) pathway in Trpm4 (-/-) mice. Authors provide evidence for the functional expression of TRPM4 channel in response to endurance training.
Study demonstrates that TRPM4 functions as a limiting factor for antigen evoked calcium rise in connective tissue type mast cells and concurrent translocation of TRPM4 into the plasma membrane is part of this mechanism.
Atrial TRPM4 channel is activated by a physiological range of Ca2 (show CA2 Proteins)+ concentrations and its excessive activity can cause arrhythmic changes.
electron cryo-microscopy structures of the mouse TRPM4 channel with and without ATP
Disrupting the Trpm4 gene in mice specifically eliminates NMDAR (show GRIN1 Proteins)-dependent LTP (show SCP2 Proteins).
observations are consistent with a model in which TRPM4 is a regulator of calcium homeostasis in cardiomyocytes after AngII stimulation
The PKC-dependent effect of GLP-1 (show GCG Proteins) on membrane potential and electrical activity was mediated by activation of Na(+)-permeable TRPM4 and TRPM5 (show TRPM5 Proteins) channels by mobilization of intracellular Ca(2 (show CA2 Proteins)+) from thapsigargin-sensitive Ca(2 (show CA2 Proteins)+) stores
The function of TRPM4 in renal primary cilia is not yet known, but it is likely to influence the apical Ca(2 (show CA2 Proteins)) dynamics of the cell
Deletion of the Trpm4 gene in mice improved survival and significantly enhanced beta-adrenergic cardiac reserve after inducing ischaemic heart failure.
The protein encoded by this gene is a calcium-activated nonselective ion channel that mediates transport of monovalent cations across membranes, thereby depolarizing the membrane. The activity of the encoded protein increases with increasing intracellular calcium concentration, but this channel does not transport calcium. Two transcript variants encoding different isoforms have been found for this gene.
transient receptor potential cation channel, subfamily M, member 4
, calcium-activated non-selective cation channel 1
, long transient receptor potential channel 4
, transient receptor potential cation channel subfamily M member 4
, melastatin like 2 protein
, melastatin-like 2
, transient receptor potential ion channel melastatin subgroup member 4