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study presents 2 structures of TRPM4 embedded in lipid nanodiscs at ~3-angstrom resolution, as determined by single-particle cryo-electron microscopy; these structures, with and without calcium bound, reveal a general architecture for this major subfamily of TRP (show TBPL1 Proteins) channels and a well-defined calcium-binding site within the intracellular side of the S1-S4 domain
Study supports the view that TRPM4 variants could be responsible for about 2% of LQT (show KCNQ1 Proteins) syndrome cases. The impact of these variants results in electrophysical disturbances.
A large pedigree diagnosed with progressive familial heart block type I was linked to a mutation of the TRPM4 ion channel.
Identify TRPM4 as a regulator of store operated calcium entry in prostate tumor cells, and demonstrate a role for TRPM4 in cancer cell migration.
TRPM4 channels regulate human detrusor smooth muscle excitability and contractility and are critical determinants of human urinary bladder function
TRPM4 protein expression is widely expressed in benign and cancerous prostate tissue
new insight into the ligand binding domains of the TRPM4 channel
Casein kinase 1 (show CSNK1A1 Proteins) phosphorylates S839 and is responsible for the basolateral localization of TRPM4.
TRPM4 acts to maintain endothelial features and its loss promotes fibrotic conversion via TGF-beta (show TGFB1 Proteins) production.
we demonstrate that the inhibition of TRPM4 activity alters cellular contractility in vivo, affecting cutaneous wound healing.
Disrupting the Trpm4 gene in mice specifically eliminates NMDAR (show GRIN1 Proteins)-dependent LTP (show SCP2 Proteins).
observations are consistent with a model in which TRPM4 is a regulator of calcium homeostasis in cardiomyocytes after AngII stimulation
The PKC-dependent effect of GLP-1 (show GCG Proteins) on membrane potential and electrical activity was mediated by activation of Na(+)-permeable TRPM4 and TRPM5 (show TRPM5 Proteins) channels by mobilization of intracellular Ca(2 (show CA2 Proteins)+) from thapsigargin-sensitive Ca(2 (show CA2 Proteins)+) stores
The function of TRPM4 in renal primary cilia is not yet known, but it is likely to influence the apical Ca(2 (show CA2 Proteins)) dynamics of the cell
Deletion of the Trpm4 gene in mice improved survival and significantly enhanced beta-adrenergic cardiac reserve after inducing ischaemic heart failure.
TRPM4 has pleiotropic roles in the heart, including the regulation of conduction and cellular electrical activity which impact heart development.
The present study demonstrates that robust TRPM4-IR is localized specifically in the soma of Inner Auditory Hair Cells in the organ of Corti.
These results showed that the cell surface expression of TRPM4 channels is mediated by 14-3-3gamma (show YWHAG Proteins) binding.
Adenylyl cyclase-mediated effects contribute to increased isoprenaline-induced cardiac contractility in TRPM4-deficient mice.
Results show that functional TRPM4 proteins are novel determinants of the inotropic effect of beta-adrenergic stimulation on the ventricular heart muscle.
The protein encoded by this gene is a calcium-activated nonselective ion channel that mediates transport of monovalent cations across membranes, thereby depolarizing the membrane. The activity of the encoded protein increases with increasing intracellular calcium concentration, but this channel does not transport calcium. Two transcript variants encoding different isoforms have been found for this gene.
transient receptor potential cation channel, subfamily M, member 4
, calcium-activated non-selective cation channel 1
, long transient receptor potential channel 4
, transient receptor potential cation channel subfamily M member 4
, melastatin like 2 protein
, melastatin-like 2
, transient receptor potential ion channel melastatin subgroup member 4