Use your antibodies-online credentials, if available.
No Products on your Comparison List.
Your basket is empty.
Find out more
Show all synonyms
Select your origin of interest
Human APOA1 Protein expressed in Escherichia coli (E. coli) - ABIN413012
Barlic, Zhu, Murphy: Atherogenic lipids induce high-density lipoprotein uptake and cholesterol efflux in human macrophages by up-regulating transmembrane chemokine CXCL16 without engaging CXCL16-dependent cell adhesion. in Journal of immunology (Baltimore, Md. : 1950) 2009
Show all 3 Pubmed References
Human APOA1 Protein expressed in Escherichia coli (E. coli) - ABIN2003220
Soutar, Hawkins, Vigushin, Tennent, Booth, Hutton, Nguyen, Totty, Feest, Hsuan: Apolipoprotein AI mutation Arg-60 causes autosomal dominant amyloidosis. in Proceedings of the National Academy of Sciences of the United States of America 1992
Show all 4 Pubmed References
identified that apolipoprotein-A1 and haptoglobin (show HP Proteins) had significant predictive values for the prediction of recovery at 12 weeks in DILI, enabling the construction of a new prognostic panel, the DILI-ActiTest, which needs to be independently validated
ApoA1 is associated with neurite outgrowth after mechanical injury by mediating polymerisation of actin and restricting inflammatory responses after injury which are deleterious to healing.
A retractable lid in lecithin:cholesterol acyltransferase provides a structural mechanism for activation by apolipoprotein A-I
Lower ApoA1 improves the risk prediction of new type 2 diabetes
Following ETC-216 administration to normal human volunteers, an initial dose-dependent HDL (show HSD11B1 Proteins)-C elevation was observed. Thereafter, subjects transiently acquired a lipoprotein profile similar to that of AIM carriers, including reduced HDL (show HSD11B1 Proteins)-C and mild hypertriglyceridemia.
The different anti-inflammatory mechanisms of the ApoA-I cysteine mutants might be associated with the regulation of ATF3 (show ATF3 Proteins) level.
Anti-apoA-1 IgG are independent predictors of nonfatal incident coronary artery disease in the general population. The strength of this association is dependent on a functional polymorphism of the CD14 receptor gene, a finding suggesting a gene-autoantibody interaction for the development of CAD.
ABCA1 (show ABCA1 Proteins)-derived nascent high-density lipoprotein-apolipoprotein AI and lipids metabolically segregate.
In vitro proteolysis of the apoA-I-Cy5.5 probe by a variety of proteases including serine, cysteine, and metalloproteases resulted in an up to 11-fold increase in fluorescence, allowing for quantification of apolipoprotein A-I proteolytic degradation.
Using atomic force microscopy, detail the ring-shaped coarse structure, and the three detailed structures of apoA-I directly derived from spherical HDL (show HSD11B1 Proteins) through NP-40-induced lipid depletion.
apoA-I/ABCA1 (show ABCA1 Proteins)-mediated cholesterol efflux without STAT3 (show STAT3 Proteins) activation can reduce proinflammatory cytokine expression in macrophages.
a novel protective role for ApoA-I in colitis and CAC (show SLC25A20 Proteins)
Our results assign a novel role for 4F(apoA-I mimetic peptide ) as a modulator of the TICE pathway and suggest that the anti-inflammatory functions of 4F may be a partial consequence of the codependent intestinal transport of both 4F and cholesterol.
Preincubation of endothelial cells with apoA-I protected against the TNF-alpha (show TNF Proteins)-induced inhibition of HTR (show F2R Proteins)-8/SVneo (trophoblast) cell integration into endothelial (UtMVEC) networks. These data suggest that a healthy lipid profile may affect pregnancy outcomes by priming endothelial cells in preparation for trophoblast invasion.
Reductions in Dio1 (show DIO1 Proteins) expression reduce the expression of ApoA-I in a 3,5,3'-triiodothyronine-/thyroid hormone (show PTH Proteins) response element-independent manner.
apoA-1 deficiency generates changes in the bone cell precursor population that increase adipoblast, and decrease osteoblast production resulting in reduced bone mass and impaired bone quality
This study suggests that enhancement of macrophage cholesterol metabolism by PPARgammais not contributed by activating ABCA1 (show ABCA1 Proteins) expression and ABCA1 (show ABCA1 Proteins)-mediated cholesterol efflux to apoAI, which is not involved by CD36 (show CD36 Proteins) expression either.
Mass spectrometry analysis of peptides derived from chemically crosslinked HDL (show HSD11B1 Proteins)-SAA (show SAA1 Proteins) particles detected multiple crosslinks between apoA1 and SAA (show SAA1 Proteins), indicating close proximity (within 25 A) of these two proteins on the HDL (show HSD11B1 Proteins) surface, providing a molecular and structural mechanism for the simultaneous binding of heparin to apoA1 and SAA (show SAA1 Proteins).
results demonstrate that double deletion of Apoe (show APOE Proteins) and Apoa1 ameliorated the amyloid pathology.
insulin (show INS Proteins) secretion and tissue rejuvenation activities of WT-reconstituted high-density lipoproteins were nearly depleted by fructosylation, but V156K-rHDL did not lose its beneficial activity.
The NABB system using engineered zebrafish apo A-I is a native-like membrane mimetic system for G-protein-coupled receptors.
Binding of apoA-I to ectopic F(0)F(1) ATPase (show ATP5E Proteins) triggers the generation of ADP, which via activation of the purinergic receptor P2Y (show P2RY1 Proteins)(12) stimulates the uptake and transport of HDL (show HSD11B1 Proteins) and initially lipid-free apoA-I by endothelial cells.
the model of a two-step process for the transendothelial transport of apoA-I in which apoA-I is initially lipidated by ABCA1 (show ABCA1 Proteins) and then further processed by ABCA1 (show ABCA1 Proteins)-independent mechanisms.
This study showed that apoA-I exerted protective effects against fatty liver disease in rabbits induced by a high-fat diet, possibly through its antioxidant actions.
The molar ratio ApoE (show APOE Proteins)/ApoA-I is negatively correlated with the enzyme activity, and positively correlated with increases in the intima-media thickness of common carotid wall and cardiac dysfunction signs.
Alterations in the Apo A (show APOA Proteins)-I pattern is a good indicator of the presence and severity of infectious diseases in the pig.Lower overall amounts of Apo A (show APOA Proteins)-I were observed in Salmonella typhimurium and Escherichia coli infections.
down-regulation of apolipoprotein A-I and A-IV messages in the liver may be mediated by interleukin 6 (show IL6 Proteins) and tumor necrosis factor-alpha (show TNF Proteins)
This gene encodes apolipoprotein A-I, which is the major protein component of high density lipoprotein (HDL) in plasma. The protein promotes cholesterol efflux from tissues to the liver for excretion, and it is a cofactor for lecithin cholesterolacyltransferase (LCAT) which is responsible for the formation of most plasma cholesteryl esters. This gene is closely linked with two other apolipoprotein genes on chromosome 11. Defects in this gene are associated with HDL deficiencies, including Tangier disease, and with systemic non-neuropathic amyloidosis.
, apolipoprotein A1
, apolipoprotein A-1
, preproapolipoprotein A-I
, apolipoprotein A-I
, apolipoprotein A-I preproprotein
, Apolipoprotein A1
, apolipoprotein A-I-like
, Apolipoprotein A-I