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Results show that miR-1 is downregulated in osteosarcoma cells but both of its targets Med1 and Med31 were overexpressed suggesting that MiR-1 plays an important role on the proliferation of osteosarcoma cells through regulation of Med1 and Med31.
Elmo1 increased the cytoplasmic localization of Med31.
As the Mediator complex is a transcriptional co-activator, results suggest that Med31 functions to promote the transcription of genes required for embryonic growth and cell proliferation.
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
, mediator complex subunit SOH1
, mediator of RNA polymerase II transcription subunit 31
, mediator of RNA polymerase II transcription, subunit 31 homolog
, mediator complex subunit 31
, mediator complex subunit soh1
, Mediator complex subunit 31
, Cell separation protein sep10
, Soh1 homolog
, Mediator complex subunit 31-A
, Mediator complex subunit soh1-A
, mediator complex subunit 31-A
, mediator complex subunit soh1-A
, mediator of RNA polymerase II transcription subunit 31-A
, mediator of RNA polymerase II transcription, subunit 31 homolog a