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mammalian mediator subunit mMED8 is an elongin BC-interacting protein that can assemble with Cul2 and Rbx1 reconstitute a ubiquitin ligase (Ubc5; E2 ubiquitin-conjugating enzyme Ubc5)
ability to inhibit both host transcription and the interferon (show IFNA Proteins) response is linked to interaction of NSs with the MED8 component of Mediator, a protein complex necessary for mRNA production
This gene encodes a protein component of the mediator complex, which aids in transcriptional activation through interaction with RNA polymerase II and gene-specific transcription factors. The encoded protein may also function in ubiquitin ligation and protein degradation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
activator-recruited cofactor 32 kDa component
, mediator of RNA polymerase II transcription subunit 8
, mediator of RNA polymerase II transcription subunit MED8
, mediator of RNA polymerase II transcription, subunit 8 homolog
, mediator complex subunit 8
, mediator complex subunit 8-A
, mediator of RNA polymerase II transcription subunit 8-A
, hypothetical protein
, Cell separation protein sep15
, Mediator complex subunit 8