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NF-YC was significantly increased in gliomas. Knockdown of NF-YC reduced brain tumor size in vivo. NF-YC played as an independent predictor of patient survival.
p53 negatively regulates the expression of the PRR11-SKA2 bidirectional transcription unit through NF-Y, suggesting that the inability to repress the PRR11-SKA2 bidirectional transcription unit after loss of p53 might contribute to tumorigenesis.
Presence of NF-Y transcription factor plays a pivotal role in transcriptional regulation of ID genes in development.
TAF12 and NFYC are transcription factors that regulate the epigenome, whereas RAD54L plays a central role in DNA repair
the expression of the adipogenic differentiation genes fatty acid binding protein-4, adiponectin, and leptin and the formation of fat droplets were impaired.
NFY-C expression was elevated in colorectal adenocarcinomas; moreover, NFY-C mRNA levels correlated with time to disease progression, while NFY-C protein expression was significantly higher in metastatic disease
The crystal structure of NF-Y bound to a 25 bp CCAAT oligonucleotide shows that the histone-fold domains dimer binds to the DNA sugar-phosphate backbone, mimicking the nucleosome H2A/H2B-DNA assembly; NF-YA both binds to NF-YB/NF-YC and inserts an alpha helix deeply into the DNA minor groove, providing sequence-specific contacts to the CCAAT box.
Sp1, NF-Y and FOXO transcription factors are involved in the regulation of LKB1 transcription.
NF-YC functions as a new corepressor of agonist-bound mineralocorticoid receptor via alteration of aldosterone-induced MR conformation
role in repressing Smad2 and Smad3 transactivating activity
The NF-YB/NF-YC structure gives insight into DNA binding and transcription regulation by CCAAT factor NF-Y.
p300 binds to multiple NF-Y trimers to regulate cyclin B2 promoter function
Histone deacetylase inhibitors can induce Gadd45 through its promoter without the need for functional p53, and both Oct-1 and NF-Y concertedly participate in trichostatin A-induced activation of the gadd45 promoter.
C/EBPbeta contributes to the induction of hepatocyte replication in response to HGF in rodents, which is likely due to post-translational modifications.
Expression levels of NF-Y target genes changed by CDKN1B correlate with clinical prognosis in multiple neoplasms.
NF-YC complexity is generated by dual promoters and alternative splicing
NF-Y binds to p73 and transcriptionally regulates platelet derived growth factor beta receptor
This gene encodes one subunit of a trimeric complex forming a highly conserved transcription factor that binds with high specificity to CCAAT motifs in the promoters of a variety of genes. The encoded protein, subunit C, forms a tight dimer with the B subunit, a prerequisite for subunit A association. The resulting trimer binds to DNA with high specificity and affinity. Subunits B and C each contain a histone-like motif. Multiple transcript variants encoding different isoforms have been found for this gene.
CAAT box DNA-binding protein subunit C
, CCAAT binding factor subunit C
, CCAAT transcription binding factor subunit gamma
, histone H1 transcription factor large subunit 2A
, nuclear transcription factor Y subunit C
, nuclear transcription factor Y subunit gamma
, transactivator HSM-1
, transactivator HSM-1/2
, transcription factor NF-Y, C subunit
, nuclear transcription factor-Y gamma
, nuclear transcription factor Y, gamma
, CAAT-box DNA-binding protein subunit C
, CCAAT binding factor of CBF-C/NFY-C
, CCAAT-binding transcription factor subunit C