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NF-YC was significantly increased in gliomas. Knockdown of NF-YC reduced brain tumor size in vivo. NF-YC played as an independent predictor of patient survival.
p53 (show TP53 Proteins) negatively regulates the expression of the PRR11-SKA2 (show FAM33A Proteins) bidirectional transcription unit through NF-Y, suggesting that the inability to repress the PRR11-SKA2 (show FAM33A Proteins) bidirectional transcription unit after loss of p53 (show TP53 Proteins) might contribute to tumorigenesis.
TAF12 (show TAF12 Proteins) and NFYC are transcription factors that regulate the epigenome, whereas RAD54L (show ATRX Proteins) plays a central role in DNA repair
the expression of the adipogenic differentiation genes fatty acid binding protein-4, adiponectin, and leptin (show LEP Proteins) and the formation of fat droplets were impaired.
NFY-C expression was elevated in colorectal adenocarcinomas; moreover, NFY-C mRNA levels correlated with time to disease progression, while NFY-C protein expression was significantly higher in metastatic disease
The crystal structure of NF-Y bound to a 25 bp CCAAT oligonucleotide shows that the histone-fold domains dimer binds to the DNA sugar-phosphate backbone, mimicking the nucleosome H2A/H2B-DNA assembly; NF-YA (show NFYA Proteins) both binds to NF-YB (show NFYB Proteins)/NF-YC and inserts an alpha helix deeply into the DNA minor groove, providing sequence-specific contacts to the CCAAT box.
Sp1 (show PSG1 Proteins), NF-Y and FOXO (show FOXO3 Proteins) transcription factors are involved in the regulation of LKB1 (show STK11 Proteins) transcription.
NF-YC functions as a new corepressor of agonist-bound mineralocorticoid receptor (show NR3C2 Proteins) via alteration of aldosterone-induced MR conformation
role in repressing Smad2 (show SMAD2 Proteins) and Smad3 (show SMAD3 Proteins) transactivating activity
The NF-YB (show NFYB Proteins)/NF-YC structure gives insight into DNA binding and transcription regulation by CCAAT factor NF-Y.
NF-Y binds to p73 (show ARHGAP24 Proteins) and transcriptionally regulates platelet derived growth factor beta receptor
This gene encodes one subunit of a trimeric complex forming a highly conserved transcription factor that binds with high specificity to CCAAT motifs in the promoters of a variety of genes. The encoded protein, subunit C, forms a tight dimer with the B subunit, a prerequisite for subunit A association. The resulting trimer binds to DNA with high specificity and affinity. Subunits B and C each contain a histone-like motif. Multiple transcript variants encoding different isoforms have been found for this gene.
CAAT box DNA-binding protein subunit C
, CCAAT binding factor subunit C
, CCAAT transcription binding factor subunit gamma
, histone H1 transcription factor large subunit 2A
, nuclear transcription factor Y subunit C
, nuclear transcription factor Y subunit gamma
, transactivator HSM-1
, transactivator HSM-1/2
, transcription factor NF-Y, C subunit
, nuclear transcription factor-Y gamma
, nuclear transcription factor Y, gamma
, CAAT-box DNA-binding protein subunit C
, CCAAT binding factor of CBF-C/NFY-C
, CCAAT-binding transcription factor subunit C