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CB-5083 decreases viability in multiple myeloma cell lines and patient-derived multiple myeloma cells, including those with background proteasome inhibitor (PI) resistance. CB-5083 has a unique mechanism of action that combines well with PIs (show CDIPT Proteins), which is likely owing to the p97 (show EIF4G2 Proteins)-dependent retro-translocation of the transcription factor, Nrf1 (show NFE2L1 Proteins), which transcribes proteasome subunit genes following exposure to a PI
Chronic kidney disease patients undergoing hemodialysis might be subjected to potential mitochondrial oxidative dysregulation and NRF1 (show NFE2L1 Proteins) down-regulation.
this study therefore identifies NRF-1 (show NFE2L1 Proteins) as a novel regulator of HIF-1a (show HIF1A Proteins).
NRF-1 (show NFE2L1 Proteins) and its target mitochondrial transcription factor A (TFAM (show TFAM Proteins)) were higher in Tamoxifen (TAM (show CCNA1 Proteins))-resistant LCC2 and LCC9 cells than TAM (show CCNA1 Proteins)-sensitive MCF-7 cells.
NRF1 (show NFE2L1 Proteins) overexpression attenuated BPDEinduced Sphase arrest via the ATM (show ATM Proteins)/Chk2 (show CHEK2 Proteins) signaling pathway.
Low NRF1 (show NFE2L1 Proteins) expression was associated lymphatic metastasis and radio-resistance in nasopharyngeal carcinoma.
EglN2 (show EGLN2 Proteins) associates with the NRF1 (show NFE2L1 Proteins)-PGC1alpha complex and controls mitochondrial function in breast cancer
Lack of aprataxin (show APTX Proteins) impairs mitochondrial functions via downregulation of the APE1 (show APEX1 Proteins)/NRF1 (show NFE2L1 Proteins)/NRF2 (show GABPA Proteins) pathway.
We show that composite nucleosomes containing mH2A and NRF-1 (show NFE2L1 Proteins) are stably positioned on gene regulatory regions and can buffer transcriptional noise associated with antiviral responses
Results present evidence in the support of E2-induced ROS (show ROS1 Proteins)-mediated AKT (show AKT1 Proteins) signalling leading to the activation of NRF-1 (show NFE2L1 Proteins)-regulated cell cycle genes.
Study identifies the endoplasmic reticulum (ER)-bound transcription factor nuclear factor erythroid 2 related factor-1 (show NFE2L1 Proteins), Nrf1/Nfe2L1 (show NFE2L1 Proteins), as a critical mediator of this process and shows that Nrf1 directly binds to and specifically senses cholesterol in the ER through a defined domain and that cholesterol regulates Nrf1 turnover, processing, localization, and activity.
data highlight a precise crosstalk between transcriptional regulation by NRF1 and epigenetic modulation during germ cell development and unequivocally demonstrate a novel role of NRF1 in spermatogenesis
our investigation shows that the ER membrane protein TCF11/Nrf1 (show NFE2L1 Proteins) is an essential component of the cellular stress response mechanism. In response to cytotoxic stress, TCF11/Nrf1 (show NFE2L1 Proteins) is retrotranslocated and transferred to the nucleus where it induces proteasome subunit expression via binding to the ARE region of the relevant promoter.
Nrf1 knockdown suppressed the death of ubiquitin-deficient N2a cells upon exposure to As(III). Therefore, the levels of p65 (show NFkBP65 Proteins)-Nrf1 may play an important role in the maintenance of cell viability under oxidative stress induced (show SQSTM1 Proteins) by As(III).
findings suggest that neurodegeneration in Nrf1 NKO mice may stem from the dysfunction of the ubiquitin-mediated regulation of neuronal proteins
Our findings demonstrate that DEE and a fraction derived from this extract exerts anti-inflammatory effects through Nrf2dependent HO-1 (show HMOX1 Proteins) expression
NRF1 (nuclear respiratory factor 1) is a methylation-sensitive transcription factor; in the absence of DNA methylation (show HELLS Proteins), NRF1 binds to new sites and induces aberrant transcription
Nrf1 plays critical roles in regulating glucose metabolism, mitochondrial function, and insulin (show INS Proteins) secretion, suggesting that Nrf1 may be a novel target to improve the function of insulin (show INS Proteins)-secreting beta-cells.
lysine-specific demethylase (show MBD2 Proteins) 1 promotes oxidative phosphorylation in white adipose tissue, in cooperation with Nrf1.
Results show that Nrf1 may not be directly responsible for the loss of Nrf2 (show NFE2L2 Proteins)-dependent inducibility of antioxidant and cytoprotective genes observed in aged animals.
Knockdown of Nrf1a or Nrf1b perturbed glutathione redox state in zebrafish embryo. Nrf1 alone is not essential for the response and recovery of glutathione to oxidative insults.
Transcription Factor A (show GTF3A Proteins) expression associated with mitochondrial biogenesis activation & high levels of NRF1 mRNA from oocyte stage onwards argue for essential function of these factors during 1st steps of bovine embryogenesis
This gene encodes a protein that homodimerizes and functions as a transcription factor which activates the expression of some key metabolic genes regulating cellular growth and nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication. The protein has also been associated with the regulation of neurite outgrowth. Alternate transcriptional splice variants, which encode the same protein, have been characterized. Additional variants encoding different protein isoforms have been described but they have not been fully characterized. Confusion has occurred in bibliographic databases due to the shared symbol of NRF1 for this gene and for 'nuclear factor (erythroid-derived 2)-like 1' which has an official symbol of NFE2L1.
, alpha palindromic-binding protein
, not really finished protein
, nuclear respiratory factor-1
, transcription factor
, nuclear respiratory factor 1