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anti-Human WWTR1 Antibodies:
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Human Polyclonal WWTR1 Primary Antibody for WB - ABIN153163
Chan, Lim, Guo, Ng, Lee, Hunziker, Zeng, Hong: A role for TAZ in migration, invasion, and tumorigenesis of breast cancer cells. in Cancer research 2008
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Human Polyclonal WWTR1 Primary Antibody for ChIP, ICC - ABIN258561
Strakova, Reed, Ihnatovych: Human transcriptional coactivator with PDZ-binding motif (TAZ) is downregulated during decidualization. in Biology of reproduction 2010
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Human Polyclonal WWTR1 Primary Antibody for ICC, IF - ABIN4357944
Bhat, Salazar, Balasubramaniyan, Wani, Heathcock, Hollingsworth, James, Gumin, Diefes, Kim, Turski, Azodi, Yang, Doucette, Colman, Sulman, Lang, Rao, Copray, Vaillant, Aldape: The transcriptional coactivator TAZ regulates mesenchymal differentiation in malignant glioma. in Genes & development 2011
Show all 3 Pubmed References
Human Polyclonal WWTR1 Primary Antibody for ICC, IF - ABIN4357945
Pathak, Meng, Zhang, Gnosa, Nandy, Adell, Holmlund, Sun: Tafazzin protein expression is associated with tumorigenesis and radiation response in rectal cancer: a study of Swedish clinical trial on preoperative radiotherapy. in PLoS ONE 2014
The authors show that the Hippo pathway transcriptional coactivators Yap1 (show YAP1 Antibodies) and Wwtr1 are specifically localized to the presumptive epidermis and notochord, and play a critical and unexpected role in posterior body extension by regulating Fibronectin (show FN1 Antibodies) assembly underneath the presumptive epidermis and surrounding the notochord.
Altogether, the data suggest that Wwtr1 establishes the compact wall architecture necessary for trabeculation, and that Nrg/Erbb2 (show ERBB2 Antibodies) signaling negatively regulates its nuclear localization and therefore its activity.
Yap (show YAP1 Antibodies)/Taz (show TAZ Antibodies)-Tead activity is necessary and sufficient for optic vesicle progenitors to adopt retinal pigment epithelium identity in zebrafish.
Taz (show TAZ Antibodies) is required in the anteroposterior patterning of the pronephric progenitor domain in the intermediate mesoderm, acting in part by regulating retinoic acid signaling in the pronephric progenitor field in the intermediate mesoderm.
Taz (show TAZ Antibodies)-depleted larvae displayed patterning defects in ventral cranial vessels that correlate with lateral displacement of thyroid follicles
When transcriptional coactivators Yap (show YAP1 Antibodies) and Taz (show TAZ Antibodies) were restricted from interacting with Tead transcription factors through expression of a dominant negative transgene, cardiac precursors failed to migrate completely to the midline.
TAZ (show TAZ Antibodies) has a critical role in osteoblast differentiation in vivo
MRTF is essential for TAZ (show TAZ Antibodies) expression; TAZ (show TAZ Antibodies) and MRTF inhibit each other's cytosolic mobility and stimulus-induced nuclear accumulation; they antagonize each other's stimulatory effect on the alpha-smooth muscle actin (show ACTG2 Antibodies) promoter, which harbours nearby cis (show CISH Antibodies)-elements for both, but synergize on isolated TEAD-elements.
YAP (show YAP1 Antibodies)/TAZ (show TAZ Antibodies) mechanotransduction integrates with cell-cell communication pathways for fine-grained orchestration of stem cell decisions.
The TAZ (show TAZ Antibodies) WW domain (show DRP2 Antibodies) exhibits a binding preference for the second of the two PPxY motifs of LATS1 in vitro. We modelled the structure of the domain in complex with LATS1 PPxY2 peptide and, through molecular dynamics simulations, show that WW domain (show DRP2 Antibodies)-PPxY2 complex is stable with some flexibility in the peptide region.
In the present review, we focus on the functions of YAP (show YAP1 Antibodies)/TAZ (show TAZ Antibodies) in cancer, discuss their potential as new therapeutic target for tumor treatment, and provide valuable suggestions for further study in this field.
functional evaluation of a HTM cell monolayer using a permeability assay demonstrated that the inhibition of YAP (show YAP1 Antibodies) and TAZ (show TAZ Antibodies) attenuated the DEX-induced impairment of permeability. These findings suggest that YAP (show YAP1 Antibodies) and TAZ (show TAZ Antibodies) play pivotal roles in the DEX-induced cytoskeletal changes of HTM cells, and reveal novel potential mechanisms for the development and progression of glaucoma
WWTR1 promotes cell proliferation and inhibits apoptosis of GC cells by regulating cell cycle/apoptosisassociated factors, and effectors in the TGFbeta (show TGFB1 Antibodies) pathway.
EphA2 (show EPHA2 Antibodies)-mediates glutaminolysis through YAP (show YAP1 Antibodies)/TAZ (show TAZ Antibodies) activation in HER2 (show ERBB2 Antibodies)-positive breast cancer and may serve as potential therapeutic targets in patients.
Depletion of either YES-associated protein (YAP (show YAP1 Antibodies)) or transcriptional coactivator with PDZ (show INADL Antibodies)-motif (TAZ (show TAZ Antibodies)) sensitised cancer cell lines to MLN8237, resulting in apoptosis and reduction in aurora-A (show AURKA Antibodies).
High TAZ (show TAZ Antibodies) expression is associated with breast cancer.
Nuclear localization of YAP (show YAP1 Antibodies) and TAZ (show TAZ Antibodies) was reduced in DMOG-treated primary tubular epithelial cells.
SnoN (show SKIL Antibodies) interacts with multiple components of the Hippo pathway to inhibit the binding of Lats2 to TAZ (show TAZ Antibodies) and the subsequent phosphorylation of TAZ (show TAZ Antibodies), leading to TAZ (show TAZ Antibodies) stabilization.
MOB1 (show HOPX Antibodies)-dependent YAP1 (show YAP1 Antibodies)/TAZ (show TAZ Antibodies)-TEAD complex functions as a transcriptional repressor of SOX9 (show SOX9 Antibodies) and thereby negatively regulates chondrogenesis.
TAZ (show TAZ Antibodies) regulates cell fate depends on not only the cell type but also its subcellular localization.
The results suggested that TAZ (show TAZ Antibodies) may suppress apoptosis and premature senescence in spermatogenic cells by inhibiting the p53 (show TP53 Antibodies)-p21 (show D4S234E Antibodies) signaling pathway, thus playing important roles in the maintenance and control of reproductive function.
The role of Yap (show YAP1 Antibodies) and Wwtr1 in the Hippo signaling pathway and the regulation of spermatogenesis in mice are reported.
Taz (show TAZ Antibodies) and Yap (show YAP1 Antibodies) have overlapping functions in promoting myoblast proliferation but Taz (show TAZ Antibodies) then switches to enhance myogenic differentiation.
A crucial role for YAP (show YAP1 Antibodies) and TAZ (show TAZ Antibodies) in the maintenance of the postnatal adrenal cortex.
TAZ (show TAZ Antibodies) is a critical factor for SRC kinase (show CSK Antibodies)-mediated intestinal tumor formation and regeneration.
YAP (show YAP1 Antibodies)/TAZ (show TAZ Antibodies) plays multifaceted roles for endothelial cell behaviors, proliferation, junction assembly, and metabolism in sprouting angiogenesis and barrier formation
Yap (show YAP1 Antibodies) and Taz (show TAZ Antibodies) leads to impaired epicardial epithelial-to-mesenchymal transition (EMT (show ITK Antibodies)) and a reduction in epicardial cell proliferation and differentiation into coronary endothelial cells.
This gene encodes a binding protein of the 14-3-3 family of proteins that regulate cell cycle progression, differentiation and apoptosis. The encoded protein is a transcriptional co-activator that binds to the PPXY motif present on transcription factors. The gene product contains a WW domain and, in the C-terminus, a conserved PDZ-binding motif. This gene is distinct from the gene encoding tafazzin. Both genes share the gene symbol Taz. Multiple transcript variants encoding different isoforms have been described.
WW domain containing transcription regulator 1
, WW domain-containing transcription regulator protein 1
, WW domain-containing transcription regulator protein 1-like
, transcriptional co-activator with PDZ-binding motif
, transcriptional coactivator with PDZ-binding motif
, transcriptional coactivator with PDZ binding motif
, transcriptional co-activator with PDZ-binding motif (TA)Z
, transcriptional co-activator with PDZ-binding motif (TAZ)